The gut, vaginal, and urine microbiome in overactive bladder: a systematic review

Sze, Christina; Pressler, Mariel; Lee, John Richard; Chughtai, Bilal

doi:10.1007/s00192-022-05127-3

Cited by 6 publications

(5 citation statements)

References 27 publications

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“…When circadian rhythms were disturbed, the microbiota in the urine was altered and its decreased abundance resulted in dysbiosis of the urinary flora. This impaired the beneficial effects of urinary microbiota on the bladder regulation and protection ( 30 , 31 ). Moreover, the bladder-gut-brain axis (BGBA) might play an indispensable role in the pathophysiology of OAB ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

A positive association between the prevalence of circadian syndrome and overactive bladder in United States adults

Xiao

Yin

Wang

et al. 2023

Front. Public Health

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ObjectiveTo explore the association between the prevalence of circadian syndrome (CircS) and overactive bladder (OAB).Materials and methodsCross-section analysis was based on the National Health and Nutrition Examination Survey 2005–2018. Data regarding OAB was collected from questionnaires. The association between the prevalence of CircS and OAB was elucidated using three multivariable logistic regression models. Stratified and interaction analyses were performed to find whether some factors can modify the association.ResultsTotally 8,033 males and 8,065 females were included. People with CircS had a significantly higher prevalence of OAB compared to the non-CircS group in the fully-adjusted model (OR = 1.238, 95%CI 1.080–1.419). A significant positive correlation between the number of CircS components and the prevalence of OAB was observed when the components were ≥ 6 (OR = 1.975, 95%CI 1.463–2.665). No significant interaction was seen in the three models.ConclusionThere is a positive association between the prevalence of CircS and OAB. When the number of components is ≥6, the prevalence of OAB shows a strongly positive correlation with the number of CircS components.

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Section: Discussionmentioning

confidence: 99%

A positive association between the prevalence of circadian syndrome and overactive bladder in United States adults

Xiao

Yin

Wang

et al. 2023

Front. Public Health

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“…63 Recent research on the gut, vaginal and urinary microbiome has shown a dysbiosis and decreased diversity of the microbiome in patients with OAB symptoms. [64][65][66][67] Further work is ongoing to understand these differences and may stimulate advances in treatment or allow us to predict which patients may respond to pre-existing treatment options.…”

Section: Microbiomementioning

confidence: 99%

Treating and Managing Urinary Incontinence: Evolving and Potential Multicomponent Medical and Lifestyle Interventions

Mohamed-Ahmed¹,

Taithongchai²,

Silva³

et al. 2023

RRU

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Incontinence is defined by either ICS 2002 or IUGA/ICS 2010 as the involuntary loss of urine and includes urgency urinary incontinence (UUI), stress urinary incontinence (SUI) or mixed urinary incontinence (MUI). It has a high worldwide prevalence with an associated impact on quality of life. Despite existing management options for the management of urinary incontinence, patients continue to be troubled by symptoms or side effects of existing treatment. There is therefore a requirement for ongoing research into treatment options for the management of UUI and SUI, that are more effective and tolerable to patients. Advances in treatment of UUI include a more selective beta 3 agonist, Vibegron, which has less impact on cardiac function than Mirabegron. Hormonal treatment, including Ospemifene and Prasterone, may improve GSM and in turn symptoms of UUI. There are advances in the types of neuromodulators available, including those that are rechargeable at home and are MRI safe. Laser has shown promising initial results. There is developing interest in the microbiome, and how this may impact future treatment modalities. Advances in treatment of SUI include the use of mobile health applications to support delivery of pelvic floor muscle training. Litoxetine, a selective serotonin reuptake inhibitor, has shown promising results at phase III trials. Functional magnetic stimulation is being developed to improve contractility of pelvic floor muscles. We also discuss interventions that improve tissue elasticity and regeneration, such as platelet rich plasma, autologous stem cell transplantation, laser therapy and radiofrequency treatment, which show short term benefits.

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“…Although the research into the microbiome is gaining momentum in concepts of OAB pathogenesis [10], its role in nocturia is not yet broadly studied. It was studied in faecal and urinary samples in a population of 30 males presenting with LUTS [22], which determined that 27 faecal and eight urinary bacteria were correlated with nocturia using 16 s ribosomal RNA sequencing.…”

Section: Omics-driven Biomarkersmentioning

confidence: 99%

“…Another study showed a close link between microbial colonisation and LUTS [9], where women with significant bacteriuria were more likely to have nocturia, urgency, bladder pain, urgency incontinence, and nocturnal enuresis. Although there are limited studies, a recent systematic review has demonstrated that the urine microbiome of patients with overactive bladder (OAB) is more predisposed to alteration from the gut or vaginal influences than in healthy controls [10]. These developments have contributed to the understanding of the underlying molecular mechanisms of LUTS.…”

Section: Introductionmentioning

confidence: 99%

‘Nocturomics’: transition to omics‐driven biomarkers of nocturia, a systematic review and future prospects

et al. 2023

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Objective To systematically review studies that investigated different biomarkers of nocturia, including omics‐driven biomarkers or ‘Nocturomics’. Materials and Methods PubMed®, Scopus®, and Embase® were searched systematically in May 2022 for research papers on biomarkers in physiological fluids and tissues from patients with nocturia. A distinction was made between biomarkers or candidates discovered by omics techniques, referred to as omics‐driven biomarkers, and classical biomarkers, measured by standard laboratory techniques and mostly thought from pathophysiological hypothesis. Results A total of 13 studies with 18 881 patients in total were included, eight of which focused on classical biomarkers including: atrial natriuretic peptide (ANP), B‐type natriuretic peptide (BNP), C‐reactive protein (CRP), aldosterone, and melatonin. Five were ‘Nocturomics’, including one that assessed the microbiome and identified 27 faecal and eight urinary bacteria correlated with nocturia; and four studies that identified candidate metabolomic biomarkers, including fatty acid metabolites, serotonin, glycerol, lauric acid, thiaproline, and imidazolelactic acid among others. To date, no biomarker is recommended in clinical practice. Nocturomics are in an embryonic phase of conception but are developing quickly. Although candidate biomarkers are being identified, none of them are yet validated on a large sample, although some preclinical studies have shown a probable role of fatty acid metabolites as a possible biomarker of circadian rhythm and chronotherapy. Conclusion Further research is needed to validate biomarkers for nocturia within the framework of a diagnostic and therapeutic precision medicine perspective. We hope this study provides a summary of the current biomarker discoveries associated with nocturia and details future prospects for omics‐driven biomarkers.

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The gut, vaginal, and urine microbiome in overactive bladder: a systematic review

Cited by 6 publications

References 27 publications

A positive association between the prevalence of circadian syndrome and overactive bladder in United States adults

A positive association between the prevalence of circadian syndrome and overactive bladder in United States adults

Treating and Managing Urinary Incontinence: Evolving and Potential Multicomponent Medical and Lifestyle Interventions

‘Nocturomics’: transition to omics‐driven biomarkers of nocturia, a systematic review and future prospects

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