The gut‐skin axis in health and disease: A paradigm with therapeutic implications

O’Neill, Catherine; Monteleone, Giovanni; McLaughlin, John; Paus, Ralf

doi:10.1002/bies.201600008

Cited by 279 publications

(300 citation statements)

References 112 publications

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“…Various skin diseases such as acne, atopic dermatitis, and psoriasis are considered as examples of dysbiosis and oral probiotics improved skin symptoms in several studies . Intestinal microbiota is considered to modulate skin dyshomeostasis via gut‐skin axis, possibly by inducing systemic immunity to gut bacteria and migration of such bacteria to the skin via the bloodstream . Second, if the HP population is reduced via antimicrobial treatment, CSU remission may be induced even if HP eradication is incomplete.…”

Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis: Effect of Helicobacter pylori eradication on chronic spontaneous urticaria

Kim

Lee

et al. 2019

Helicobacter

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Background Helicobacter pylori (HP) infection is considered to play a role in the pathogenesis of chronic spontaneous urticaria (CSU). However, the efficacy of HP eradication therapy on CSU symptom improvement has not been well established. This meta‐analysis was conducted to estimate the association between HP infection and CSU and to evaluate whether HP eradication therapy benefits patients with CSU. Material and Methods In October 2018, we searched databases for studies investigating the efficacy of HP eradication therapy for patients with CSU. Risk ratios (RRs) and 95% confidence intervals (CIs) were pooled using random effects models. Results The meta‐analysis included 22 studies with a total of 1385 patients with CSU. When comparing the spontaneous remission of urticarial symptom in patients with HP‐positive to HP‐negative patients, HP‐negative patients showed significantly higher spontaneous remission of urticarial symptoms. (risk ratio 0.39; 95% confidence interval: 0.19‐0.81). Among HP‐positive CSU patients, remission of CSU was more likely shown in HP eradication therapy group compared to untreated group, aside from achieving HP elimination (risk ratio 2.10; 95% confidence interval: 1.20‐3.68). However, there was no significant difference in the remission of CSU whether antibiotic therapy was successful in eradication of HP or not (risk ratio 1.00; 95% confidence interval: 0.65‐1.54). Conclusions The results of this meta‐analysis show that HP might be associated with the occurrence and persistence of CSU. The effectiveness of HP eradication therapy in suppressing CSU symptoms was significant. Interestingly, we found that resolution of CSU was not associated with successful eradication of HP infection. CSU Patients who were undergone antibiotic therapy for HP eradication showed significant higher CSU remission with or without HP eradication. Further studies are recommended to evaluate the mechanisms associated with relation of HP with CSU.

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Section: Discussionmentioning

confidence: 99%

Systematic review and meta‐analysis: Effect of Helicobacter pylori eradication on chronic spontaneous urticaria

Kim

Lee

et al. 2019

Helicobacter

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“…They are critical immunological barriers and constitute the environment for physiological microflora. The interaction of both organs has been well established in case of inflammatory bowel diseases, rosacea, gastrointestinal malignancies and Peutz–Jeghers syndrome . Inflammatory bowel diseases (IBD) are autoimmune disorders commonly associated with extraintestinal manifestations, which may affect the skin as psoriatic lesions, erythema nodosum and pyoderma gangrenosum.…”

Section: Methodsmentioning

confidence: 99%

“…The interaction of both organs has been well established in case of inflammatory bowel diseases, rosacea, gastrointestinal malignancies and Peutz-Jeghers syndrome. 27 Inflammatory bowel diseases (IBD) are autoimmune disorders commonly associated with extraintestinal manifestations, which may affect the skin as psoriatic lesions, erythema nodosum and pyoderma gangrenosum. Satta et al observed lower skin lesion incidence in patients with IBD, who underwent probiotic supplementation.…”

Section: The Gut-skin Axismentioning

confidence: 99%

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Polkowska-Pruszyńska

Gerkowicz

Krasowska

2019

Acad Dermatol Venereol

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The human microbiome is a wide range of microorganisms residing in and on our body. The homeostasis between host immune system and the microbial environment allows mutual benefits and protection. Physiological bacterial colonization is essential for the establishment of organism immunity. The human microbiota ecosystem can be divided into several compartments, out of which intestinal flora strongly affects our health and plays a crucial role in the pathophysiology of many diseases. The gastrointestinal tract, being a major guardian of the immune system, maintains the homeostasis with the commensal microorganisms by tolerating the typical flora antigens. The dysbiosis may trigger an inflammatory response followed by tissue damage or autoimmune processes. The gut microbiome alterations are linked to the pathogenesis of the allergic, cardiovascular, gastrointestinal, metabolic, neurodevelopmental, psychiatric and neurodegenerative diseases and cancer. Moreover, there is increasing evidence connecting the skin condition with the gastrointestinal microbiome, which has been described as the skin–gut axis. The aim of this study was to review the literature regarding the role of the gut microbiome alterations in the pathogenesis of selected allergic and inflammatory skin diseases.

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“…354 In healthy state, different types of interactions occur between the gut and skin. Gut microbiota produce metabolites, hormones, and neurotransmitters that can enter the blood circulation and affect the skin function.…”

Section: The Gut-skin Axis and Gut-brain-skin Axismentioning

confidence: 99%

Exploring the microbiome in health and disease

Scotti

Boué

Sasso

et al. 2017

Toxicology Research and Application

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The analysis of human microbiome is an exciting and rapidly expanding field of research. In the past decade, the biological relevance of the microbiome for human health has become evident. Microbiome comprises a complex collection of microorganisms, with their genes and metabolites, colonizing different body niches. It is now well known that the microbiome interacts with its host, assisting in the bioconversion of nutrients and detoxification, supporting immunity, protecting against pathogenic microbes, and maintaining health. Remarkable new findings showed that our microbiome not only primarily affects the health and function of the gastrointestinal tract but also has a strong influence on general body health through its close interaction with the nervous system and the lung. Therefore, a perfect and sensitive balanced interaction of microbes with the host is required for a healthy body. In fact, growing evidence suggests that the dynamics and function of the indigenous microbiota can be influenced by many factors, including genetics, diet, age, and toxicological agents like cigarette smoke, environmental contaminants, and drugs. The disruption of this balance, that is called dysbiosis, is associated with a plethora of diseases, including metabolic diseases, inflammatory bowel disease, chronic obstructive pulmonary disease, periodontitis, skin diseases, and neurological disorders. The importance of the host microbiome for the human health has also led to the emergence of novel therapeutic approaches focused on the intentional manipulation of the microbiota, either by restoring missing functions or eliminating harmful roles. In the present review, we outline recent studies devoted to elucidate not only the role of microbiome in health conditions and the possible link with various types of diseases but also the influence of various toxicological factors on the microbial composition and function.

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The gut‐skin axis in health and disease: A paradigm with therapeutic implications

Cited by 279 publications

References 112 publications

Systematic review and meta‐analysis: Effect of Helicobacter pylori eradication on chronic spontaneous urticaria

Systematic review and meta‐analysis: Effect of Helicobacter pylori eradication on chronic spontaneous urticaria

The gut microbiome alterations in allergic and inflammatory skin diseases – an update

Exploring the microbiome in health and disease

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