The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation

Chen, Sheng-Lun; Lundy, David J.; Ruan, Shu-Chian; Chen, Hung-Chih; Chao, Yu-Kai; Cheng, Yu‐Shia; Prajnamitra, Ray Putra; Liao, Chun-Chieh; Lin, Chung-Yen; Lai, James J.; Hsieh, Patrick C.

doi:10.1016/j.biomaterials.2022.121807

Cited by 6 publications

(6 citation statements)

References 51 publications

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“…149 One study even demonstrated that in antibiotic-treated and germ-free mice, the fibrotic capsule surrounding a silicone implant was reduced relative to specific pathogen-free (SPF) mice. 150 Therefore, it is likely that different gut microbiota compositions from person to person will influence the development and outcome of the FBR.…”

Section: Challenges For Targeting the Fbr In Humansmentioning

confidence: 99%

The foreign body response: emerging cell types and considerations for targeted therapeutics

Yang,

Rutkowski,

Elisseeff

2023

Biomater. Sci.

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Section: Challenges For Targeting the Fbr In Humansmentioning

confidence: 99%

The foreign body response: emerging cell types and considerations for targeted therapeutics

Yang,

Rutkowski,

Elisseeff

2023

Biomater. Sci.

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“…Following implantation, foreign materials are rapidly covered with adsorbed proteins and host cells are recruited to the area. Circulating neutrophils, monocytes, and tissue macrophages adhere to the foreign material, and surrounding tissue fibroblasts differentiate into collagen-secreting myofibroblasts. , The intensity and duration of the host response varies depending on many factors including the location of the implant site, the material surface properties, material dimensions, and attributes of the host . Implants that cannot be degraded and removed may be subsequently surrounded by a capsule of fibrous material, which can interfere with implant function, cause patient discomfort, and produce undesired aesthetic outcomes. , For supporting cell therapy, a degradable material would allow for noninvasive removal of the implant, which would be advantageous for some applications where a permanent implant is not required.…”

Section: Introductionmentioning

confidence: 99%

“…Circulating neutrophils, monocytes, and tissue macrophages adhere to the foreign material, and surrounding tissue fibroblasts differentiate into collagen-secreting myofibroblasts. 18 , 19 The intensity and duration of the host response varies depending on many factors including the location of the implant site, the material surface properties, material dimensions, and attributes of the host. 19 Implants that cannot be degraded and removed may be subsequently surrounded by a capsule of fibrous material, which can interfere with implant function, cause patient discomfort, and produce undesired aesthetic outcomes.…”

Section: Introductionmentioning

confidence: 99%

“… 18 , 19 The intensity and duration of the host response varies depending on many factors including the location of the implant site, the material surface properties, material dimensions, and attributes of the host. 19 Implants that cannot be degraded and removed may be subsequently surrounded by a capsule of fibrous material, which can interfere with implant function, cause patient discomfort, and produce undesired aesthetic outcomes. 20 , 21 For supporting cell therapy, a degradable material would allow for noninvasive removal of the implant, which would be advantageous for some applications where a permanent implant is not required.…”

Section: Introductionmentioning

confidence: 99%

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Degradable Biocompatible Porous Microtube Scaffold for Extended Donor Cell Survival and Activity

Nguyen

Chen

Czosseck

et al. 2023

ACS Biomater. Sci. Eng.

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Cell therapy has significant therapeutic potential but is often limited by poor donor cell retention and viability at the host implantation site. Biomaterials can improve cell retention by providing cells with increased cell−cell and cell−matrix contacts and materials that allow three-dimensional cell culture to better recapitulate native cell morphology and function. In this study, we engineered a scaffold that allows for cell encapsulation and sustained threedimensional cell culture. Since cell therapy is largely driven by paracrine secretions, the material was fabricated by electrospinning to have a large internal surface area, micrometer-thin walls, and nanoscale surface pores to allow for nutrient exchange without early cell permeation. The material is degradable, which allows for less invasive removal of the implant. Here, a biodegradable poly(lactic-co-glycolic acid) (PLGA) microtube array membrane was fabricated.In vitro testing showed that the material supported the culture of human dermal fibroblasts for at least 21 days, with paracrine secretion of pro-angiogenic FGF2. In vivo xenotransplantation of human cells in an immunocompetent mouse showed that donor cells could be maintained for more than one month and the material showed no obvious toxicity. Analysis of gene expression and tissue histology surrounding the implant showed that the material produced muted inflammatory and immune responses compared to a permanent implant and increased markers of angiogenesis.

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“…The main problem seems to be the overabundance of certain microbes, not their general presence or absence [26]. It has been shown that biomaterials mainly affect biofilm composition, gene expression and protein production [27], [28]. Does this mean that future research should focus on transcriptomics and proteome analysis?…”

Section: Introductionmentioning

confidence: 99%

THE IMPACT OF IMPLANTED BIOMATERIAL TO THE MICROBIOME Does technology change human or we change technology?

Paulić,

Perić-Kačarević,

Bogdan

2023

DBR

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Contemporary medicine is unimaginabile without biotechnological involvment in diagnostic and therapeutic purpouses, but sometimes the discovery and application of new materials go faster then the understanding and adoption of the knowledge about the consequences for our organism. Understanding of biological processes at the microscopycal and molecular level would lead to better integration of biomaterial with human body environment. The primary aim of this review was to evaluate the potential microbiological effect after biomaterial and implant insertions to oral microbiota. The secundary aim was to evaluate if such microbiological shift has any effect to surgical wound-healing, post-implant tissue reaction or rejection of implanted biomaterial. The third aim was to question previous results of similar reviews and studies regarding microbiological role in improving therapeutic responses after biomaterial implantation in dental medicine. A comprehensive systematic search via Web of Science, Scopus and PubMed databases was conducted. The data synthesis showed similar results among clinical studies and several reviews with ambiguous conclusions leaving numerous questions without straight answers. We hypothesized that relationship between host microbiome and biomaterial insertion is mutual, but within the limitations of this review, the interaction between host-oral microbiota and material inset remains uncharted territory.

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The gut microbiota regulates acute foreign body reaction and tissue repair after biomaterial implantation

Cited by 6 publications

References 51 publications

The foreign body response: emerging cell types and considerations for targeted therapeutics

The foreign body response: emerging cell types and considerations for targeted therapeutics

Degradable Biocompatible Porous Microtube Scaffold for Extended Donor Cell Survival and Activity

THE IMPACT OF IMPLANTED BIOMATERIAL TO THE MICROBIOME Does technology change human or we change technology?

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