The Gut Microbiota May Affect Personality in Mongolian Gerbils

Gan, Lin; Bo, Tingbei; Liu, Wei; Wang, Dehua

doi:10.3390/microorganisms10051054

Cited by 5 publications

(1 citation statement)

References 66 publications

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“…Studies on animal models revealed the connection between intestinal microbiota composition and its personalities and behavior, such as anxiety or depression. Gan et al [ 153 ] showed changes in the behavior of shy personalities of Mongolian gerbils (Meriones unguiculates) after transplantation of the gut microbiota of bold individuals. Shy gerbils often exhibited bold behavior after “bold fecal microbiota” transplantation, suggesting the association between the gut microbiota and the host’s personality.…”

Section: The Intestinal Microbiota In Neurological and Psychiatric Di...mentioning

confidence: 99%

The Microbiota–Gut–Brain Axis in Psychiatric Disorders

Góralczyk-Bińkowska

Szmajda-Krygier

Kozłowska

2022

IJMS

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Modulating the gut microbiome and its influence on human health is the subject of intense research. The gut microbiota could be associated not only with gastroenterological diseases but also with psychiatric disorders. The importance of factors such as stress, mode of delivery, the role of probiotics, circadian clock system, diet, and occupational and environmental exposure in the relationship between the gut microbiota and brain function through bidirectional communication, described as “the microbiome–gut–brain axis”, is especially underlined. In this review, we discuss the link between the intestinal microbiome and the brain and host response involving different pathways between the intestinal microbiota and the nervous system (e.g., neurotransmitters, endocrine system, immunological mechanisms, or bacterial metabolites). We review the microbiota alterations and their results in the development of psychiatric disorders, including major depressive disorder (MDD), schizophrenia (SCZ), bipolar disorder (BD), autism spectrum disorder (ASD), and attention-deficit hyperactivity disorder (ADHD).

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Section: The Intestinal Microbiota In Neurological and Psychiatric Di...mentioning

confidence: 99%

The Microbiota–Gut–Brain Axis in Psychiatric Disorders

Góralczyk-Bińkowska

Szmajda-Krygier

Kozłowska

2022

IJMS

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Multi-assay approach shows species-associated personality patterns in two socially distinct gerbil species

Tchabovsky,

Surkova,

Savinetskaya

2023

Preprint

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We aimed to investigate whether two closely related but socially distinct species of gerbils differ in personality patterns. Using a suit of multivariate repeated assays (docility test, dark-light emergence test, startle test, novel object test, elevated platform test, and stranger test), we assessed contextual and temporal consistency of docility, boldness, exploration, anxiety, and sociability in the solitary midday gerbil,Meriones meridianus, and social Mongolian gerbil,M. unguiculatus. We revealed contextually consistent and highly repeatable sex-independent but species-specific personality traits. Species differed in temporal repeatability of different behaviours, and contextual consistency was more pronounced in solitaryM. meridianusthan in socialM. unguiculatus. This finding contradicts the social niche specialization hypothesis, which suggests that personality traits should be more consistent in more social species. Instead, we hypothesize that social complexity should favour more flexible and less consistent behavioural traits. The habituation effect indicative of learning abilities was weak in both species yet stronger in socialM. unguiculatus, supporting the relationship between the sociality level and cognitive skills. In both species, only a few different behavioural traits covaried, and the sets of correlated behaviours were species-specific such that the two species did not share any pair of correlated traits. Between-species differences in personality traits, habituation, and behavioural syndromes may be linked to differences in sociality. The lack of prominent behavioural syndromes is consistent with the idea that context-specific individual behavioural traits might be favoured to allow more flexible and adequate responses to changing environments than syndromes of correlated functionally different behaviours.

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Bridging the gap: associations between gut microbiota and psychiatric disorders

Ahmed,

Ramadan,

Elbeh

et al. 2024

Middle East Curr Psychiatry

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Background Gut microbiota plays a pivotal role in the gut-brain axis and can influence neurodevelopment and mental health outcomes. This review summarizes the current evidence on the associations between gut microbiota alterations and various psychiatric illnesses. Main body The composition of the gut microbiome evolves from birth through old age, and disruptions during critical periods may increase disease risk. Factors like diet, medications, stress, and infections can disturb the gut microenvironment and lead to dysbiosis. Dysbiosis has been linked to conditions like depression, anxiety, autism, ADHD, and schizophrenia. Proposed mechanisms involve microbial regulation of neurotransmitters, inflammation, oxidative stress, blood-brain barrier permeability, and the immune system. Therapeutic strategies like probiotics, prebiotics, and faecal transplantation may modulate the gut-brain axis and microbial ecosystem. However, more research is needed to elucidate the causal microbiota-psychiatry relationship. Understanding gut-brain interactions may uncover new possibilities for preventing and managing psychiatric disorders. Conclusion A growing body of research points to a close relationship between gut microbiota and mental health. While the field is still emerging, dysbiosis of gut microbial ecosystem has been associated with various neuropsychiatric conditions. The underlying mechanisms likely involve the microbiota-gut-brain axis signalling pathways. Additional research with larger samples is required to establish causal links between specific microbial changes and psychiatric outcomes.

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The Gut Microbiota May Affect Personality in Mongolian Gerbils

Cited by 5 publications

References 66 publications

The Microbiota–Gut–Brain Axis in Psychiatric Disorders

The Microbiota–Gut–Brain Axis in Psychiatric Disorders

Multi-assay approach shows species-associated personality patterns in two socially distinct gerbil species

Bridging the gap: associations between gut microbiota and psychiatric disorders

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