“…One of the most studied pathogen-associated molecular patterns (PAMPs) concerning cardiovascular function and the increase in CVD risk is lipopolysaccharide (LPS), a Gram-negative bacterial cell wall component [143,144]. Circulating LPS is raised in at-risk individuals and predicts future CVD [145][146][147]; accordingly, administration of low-doses of LPS induces vascular inflammation and atherosclerosis in experimental animals [148,149].…”
Section: Other Microbiota Aspects Related To Cardiovascular Diseasesmentioning
confidence: 99%
“…In the last 10 years, it has been observed that there is a possible relationship between the intestinal microbiota and the cardiovascular system [11,144,182,183]. Human cardiometabolic health has been related with variations in the gut microbiota composition (dysbiosis) [184].…”
Section: Physical Activity Microbiota and Cardiovascular Diseasesmentioning
confidence: 99%
“…It is known that voluntary running exercise modifies the microbiota composition of the cecum and increases the n-butyrate concentration in the cecal content [189]. Butyrate is one of the three most important SCFAs, and several studies have shown that it may have effects on cardiovascular function [97,144,183]. Nevertheless, more studies are needed to explore the principal physiological mechanisms that relate regular exercise to SCFA levels and its effect on blood pressure and inflammation.…”
Section: Physical Activity Microbiota and Cardiovascular Diseasesmentioning
The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota.
“…One of the most studied pathogen-associated molecular patterns (PAMPs) concerning cardiovascular function and the increase in CVD risk is lipopolysaccharide (LPS), a Gram-negative bacterial cell wall component [143,144]. Circulating LPS is raised in at-risk individuals and predicts future CVD [145][146][147]; accordingly, administration of low-doses of LPS induces vascular inflammation and atherosclerosis in experimental animals [148,149].…”
Section: Other Microbiota Aspects Related To Cardiovascular Diseasesmentioning
confidence: 99%
“…In the last 10 years, it has been observed that there is a possible relationship between the intestinal microbiota and the cardiovascular system [11,144,182,183]. Human cardiometabolic health has been related with variations in the gut microbiota composition (dysbiosis) [184].…”
Section: Physical Activity Microbiota and Cardiovascular Diseasesmentioning
confidence: 99%
“…It is known that voluntary running exercise modifies the microbiota composition of the cecum and increases the n-butyrate concentration in the cecal content [189]. Butyrate is one of the three most important SCFAs, and several studies have shown that it may have effects on cardiovascular function [97,144,183]. Nevertheless, more studies are needed to explore the principal physiological mechanisms that relate regular exercise to SCFA levels and its effect on blood pressure and inflammation.…”
Section: Physical Activity Microbiota and Cardiovascular Diseasesmentioning
The importance of gut microbiota in health and disease is being highlighted by numerous research groups worldwide. Atherosclerosis, the leading cause of heart disease and stroke, is responsible for about 50% of all cardiovascular deaths. Recently, gut dysbiosis has been identified as a remarkable factor to be considered in the pathogenesis of cardiovascular diseases (CVDs). In this review, we briefly discuss how external factors such as dietary and physical activity habits influence host-microbiota and atherogenesis, the potential mechanisms of the influence of gut microbiota in host blood pressure and the alterations in the prevalence of those bacterial genera affecting vascular tone and the development of hypertension. We will also be examining the microbiota as a therapeutic target in the prevention of CVDs and the beneficial mechanisms of probiotic administration related to cardiovascular risks. All these new insights might lead to novel analysis and CVD therapeutics based on the microbiota.
“…66 Gut dysbiosis is associated with intestinal inflammation and has been linked to the development of CVD. 67 However, there is no evidence that restoring gut dysbiosis with tubers improves CV outcomes. Intake of potatoes, for instance, provides a large amount of rapidly absorbed carbohydrate (glycaemic load), and its daily consumption has been associated with increased risk of type 2 diabetes, hypertension, weight gain and even CHD (especially consumed in the form of "French fries").…”
Section: Grains and Tubersmentioning
confidence: 99%
“…Intake of potatoes, for instance, provides a large amount of rapidly absorbed carbohydrate (glycaemic load), and its daily consumption has been associated with increased risk of type 2 diabetes, hypertension, weight gain and even CHD (especially consumed in the form of "French fries"). [68][69][70][71] Evidence does not support strong recommendations on the specific proportion of energy intake from carbohydrates, but keeping this to <60% of energy appears desirable, and consumption of whole grains is emphasised. This would be about 232 g/day of whole grains, and 50 g/day of tubers and starchy vegetables (with a limit of 100 g/day of tubers and starchy vegetables).…”
Cardiovascular disease is the leading global cause of death in Western countries, and its development is largely associated with unhealthy dietary patterns. A large body of scientific evidence has reported that nutrition might be the most preventive factor of cardiovascular disease death and could even reverse heart disease. Processes of chronic inflammation and oxidative distress share triggers that are modifiable by nutrition. This review aimed to identify potential targets (food patterns, single foods or individual nutrients) for cardiovascular disease prevention, and analyse the mechanisms implicated in their cardioprotective effects.
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