The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies

Dualib, Patricia; Fernandes, Gabriel R.; Taddei, Carla R.; Carvalho, Cristina Valletta de; Sparvoli, Luiz Gustavo; Bittencourt, Célia; Silva, Isis T; Mattar, Rosiane; Ferreira, Sandra; Dib, Sérgio Atala; Almeida-Pititto, Bianca de

doi:10.1186/s13098-022-00954-2

Cited by 4 publications

(1 citation statement)

References 45 publications

(35 reference statements)

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“…Setting aside the discussion about the presence or absence of the placental microbiome in the context of healthy pregnancy, studies have reported changes in the GM profile in pregnant women with gestational disorders such as preeclampsia (PE), gestational diabetes mellitus (GDM), fetal growth restriction (FGR), maternal obesity, among others. Supplementary Table 1 describes the profile of the microbiota in such gestational alterations (28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43).…”

Section: Microbiome Alterations In Pregnancy Disordersmentioning

confidence: 99%

From gut to placenta: understanding how the maternal microbiome models life-long conditions

Ruiz-Triviño,

Álvarez,

Cadavid J.

et al. 2023

Front. Endocrinol.

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The microbiome -defined as the microbiota (bacteria, archaea, lower and higher eukaryotes), their genomes, and the surrounding environmental conditions- has a well-described range of physiological functions. Thus, an imbalance of the microbiota composition -dysbiosis- has been associated with pregnancy complications or adverse fetal outcomes. Although there is controversy about the existence or absence of a microbiome in the placenta and fetus during healthy pregnancy, it is known that gut microbiota can produce bioactive metabolites that can enter the maternal circulation and may be actively or passively transferred through the placenta. Furthermore, the evidence suggests that such metabolites have some effect on the fetus. Since the microbiome can influence the epigenome, and modifications of the epigenome could be responsible for fetal programming, it can be experimentally supported that the maternal microbiome and its metabolites could be involved in fetal programming. The developmental origin of health and disease (DOHaD) approach looks to understand how exposure to environmental factors during periods of high plasticity in the early stages of life (e.g., gestational period) influences the program for disease risk in the progeny. Therefore, according to the DOHaD approach, the influence of maternal microbiota in disease development must be explored. Here, we described some of the diseases of adulthood that could be related to alterations in the maternal microbiota. In summary, this review aims to highlight the influence of maternal microbiota on both fetal development and postnatal life, suggesting that dysbiosis on this microbiota could be related to adulthood morbidity.

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Section: Microbiome Alterations In Pregnancy Disordersmentioning

confidence: 99%

From gut to placenta: understanding how the maternal microbiome models life-long conditions

Ruiz-Triviño,

Álvarez,

Cadavid J.

et al. 2023

Front. Endocrinol.

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Gut microbiota dysbiosis -associated obesity and its involvement in cardiovascular diseases and type 2 diabetes. A systematic review

Hamjane,

Mechita,

Nourouti

et al. 2024

Microvascular Research

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Designing a behaviour change intervention using COM‐B and the Behaviour Change Wheel: Co‐designing the Healthy Gut Diet for preventing gestational diabetes

Meloncelli,

O'Connor,

de Jersey

et al. 2024

J Human Nutrition Diet

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BackgroundEvidence suggests that modulating the gut microbiota during pregnancy may help prevent gestational diabetes mellitus (GDM). The Healthy Gut Diet study is a complex behaviour change intervention co‐designed with women who have a lived experience of GDM. The aim of the study was to describe the development of the behaviour change dietary intervention, the Healthy Gut Diet.MethodsThis study followed the process for designing behaviour change interventions using the Behaviour Change Wheel. Six researchers and 12 women with lived experience participated in online workshops to co‐design the Healthy Gut Diet intervention. This included “diagnosing” the barriers and enablers to two target behaviours: eating more plant foods and eating less ultra processed/saturated fat containing foods. Content analysis of the workshop transcripts and activities was undertaken, underpinned by the Capability, Opportunity, Motivation and Behaviour (COM‐B) model and the Theoretical Domains Framework (TDF).ResultsBarriers and enablers to the target behaviours were described across all six COM‐B components and 10 TDF domains. The intervention functions for the Healthy Gut Diet were education, enablement, environmental restructuring, persuasion and incentivisation. Forty behaviour change techniques were integrated into five modes of delivery for the Healthy Gut Diet intervention. The feasibility, acceptability and effectiveness of the Healthy Gut Diet is being tested within a randomised controlled trial.ConclusionsUsing the Behaviour Change Wheel process in partnership with consumers resulted in a clearly described complex intervention targeting barriers and enablers of dietary behaviour change to improve the gut microbiota diversity in pregnant women.

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The gut microbiome of obese postpartum women with and without previous gestational diabetes mellitus and the gut microbiota of their babies

Cited by 4 publications

References 45 publications

From gut to placenta: understanding how the maternal microbiome models life-long conditions

From gut to placenta: understanding how the maternal microbiome models life-long conditions

Gut microbiota dysbiosis -associated obesity and its involvement in cardiovascular diseases and type 2 diabetes. A systematic review

Designing a behaviour change intervention using COM‐B and the Behaviour Change Wheel: Co‐designing the Healthy Gut Diet for preventing gestational diabetes

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