The gut microbiome is required for full protection against acute arsenic toxicity in mouse models

Coryell, Michael; McAlpine, Mark; Pinkham, Nicholas V.; McDermott, Timothy R.; Walk, Seth T.

doi:10.1038/s41467-018-07803-9

Cited by 158 publications

(113 citation statements)

References 41 publications

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“…In light of these studies, using the microbiome to reduce metalloid toxicity is now starting to be explored, with Coryell et al . establishing that the mouse gut community assists in reducing host mortality upon arsenic exposure (Coryell et al, ).…”

Section: Introductionmentioning

confidence: 99%

The bumble bee microbiome increases survival of bees exposed to selenate toxicity

Rothman

Leger

Graystock

et al. 2019

Environmental Microbiology

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Summary Bumble bees are important and widespread insect pollinators who face many environmental challenges. For example, bees are exposed to the metalloid selenate when foraging on pollen and nectar from plants growing in contaminated soils. As it has been shown that the microbiome of animals reduces metalloid toxicity, we assayed the ability of the bee microbiome to increase survivorship against selenate challenge. We exposed uninoculated or microbiota‐inoculated Bombus impatiens workers to a field‐realistic dose of 0.75 mg l−1 selenate and found that microbiota‐inoculated bees survive slightly but significantly longer than uninoculated bees. Using 16S rRNA gene sequencing, we found that selenate exposure altered gut microbial community composition and relative abundance of specific core bacteria. We also grew two core bumble bee microbes – Snodgrassella alvi and Lactobacillus bombicola – in selenate‐spiked media and found that these bacteria grew in the tested concentrations of 0.001–10 mg l−1 selenate. Furthermore, the genomes of these microbes harbour genes involved in selenate detoxification. The bumble bee microbiome slightly increases survivorship when the host is exposed to selenate, but the specific mechanisms and colony‐level benefits under natural settings require further study.

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Section: Introductionmentioning

confidence: 99%

The bumble bee microbiome increases survival of bees exposed to selenate toxicity

Rothman

Leger

Graystock

et al. 2019

Environmental Microbiology

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“…(), the mouse gut microbiomes performed a bioaccumulation function, resulting in increased arsenic concentrations in mouse stool while simultaneously reducing arsenic uptake and accumulation in the mouse liver, spleen, heart and lung (Coryell et al ., ). Further, humanizing germ‐free As3mt − knockout mice (hypersensitive to arsenic) with stool homogenates from different human donors clearly demonstrated how the GIT microorganisms provide a protective measure by significantly reducing arsenic‐induced mortality, although varying between human stool donors (Coryell et al ., ). Illumina 16S metagenome analysis of these arsenic‐exposed humanized mouse microbiomes suggested Faecalibacterium plays an important role, and indeed mice co‐colonized with F .…”

Section: Arsenic and The Git Microbiomementioning

confidence: 97%

“…prausnitzii ) mice were afforded significantly increased protection against arsenic relative to mice mono‐associated with E . coli (Coryell et al ., ).…”

Section: Arsenic and The Git Microbiomementioning

confidence: 97%

“…A recent study by Coryell et al . () used a combination of antibiotic‐disturbed mouse microbiomes and germ‐free mice to directly address the question of whether a gut microbiome can be of value to the host. In this study and similarly in a just recently reported study by Chi et al .…”

Section: Arsenic and The Git Microbiomementioning

confidence: 99%

“…A recent study by Coryell et al (2018) used a combination of antibiotic-disturbed mouse microbiomes and germ-free mice to directly address the question of whether a gut microbiome can be of value to the host. In this study and similarly in a just recently reported study by Chi et al (2019), the mouse gut microbiomes performed a bioaccumulation function, resulting in increased arsenic concentrations in mouse stool while simultaneously reducing arsenic uptake and accumulation in the mouse liver, spleen, heart and lung (Coryell et al, 2018).…”

Section: Evidence Of Microbiome As Interactionsmentioning

confidence: 99%

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Arsenic and the gastrointestinal tract microbiome

McDermott

Stolz

Oremland

2020

Environ Microbiol Rep

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Summary Arsenic is a toxin, ranking first on the Agency for Toxic Substances and Disease Registry and the Environmental Protection Agency Priority List of Hazardous Substances. Chronic exposure increases the risk of a broad range of human illnesses, most notably cancer; however, there is significant variability in arsenic‐induced disease among exposed individuals. Human genetics is a known component, but it alone cannot account for the large inter‐individual variability in the presentation of arsenicosis symptoms. Each part of the gastrointestinal tract (GIT) may be considered as a unique environment with characteristic pH, oxygen concentration, and microbiome. Given the well‐established arsenic redox transformation activities of microorganisms, it is reasonable to imagine how the GIT microbiome composition variability among individuals could play a significant role in determining the fate, mobility and toxicity of arsenic, whether inhaled or ingested. This is a relatively new field of research that would benefit from early dialogue aimed at summarizing what is known and identifying reasonable research targets and concepts. Herein, we strive to initiate this dialogue by reviewing known aspects of microbe–arsenic interactions and placing it in the context of potential for influencing host exposure and health risks. We finish by considering future experimental approaches that might be of value.

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Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans

Santos,

Matos,

Flatt

et al. 2023

Ecology and Evolution

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Microbes can have profound effects on host fitness and health and the appearance of late‐onset diseases. Host–microbe interactions thus represent a major environmental context for healthy aging of the host and might also mediate trade‐offs between life‐history traits in the evolution of host senescence. Here, we have used the nematode Caenorhabditis elegans to study how host–microbe interactions may modulate the evolution of life histories and aging. We first characterized the effects of two non‐pathogenic and one pathogenic Escherichia coli strains, together with the pathogenic Serratia marcescens DB11 strain, on population growth rates and survival of C. elegans from five different genetic backgrounds. We then focused on an outbred C. elegans population, to understand if microbe‐specific effects on the reproductive schedule and in traits such as developmental rate and survival were also expressed in the presence of males and standing genetic variation, which could be relevant for the evolution of C. elegans and other nematode species in nature. Our results show that host–microbe interactions have a substantial host‐genotype‐dependent impact on the reproductive aging and survival of the nematode host. Although both pathogenic bacteria reduced host survival in comparison with benign strains, they differed in how they affected other host traits. Host fertility and population growth rate were affected by S. marcescens DB11 only during early adulthood, whereas this occurred at later ages with the pathogenic E. coli IAI1. In both cases, these effects were largely dependent on the host genotypes. Given such microbe‐specific genotypic differences in host life history, we predict that the evolution of reproductive schedules and senescence might be critically contingent on host–microbe interactions in nature.

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The gut microbiome is required for full protection against acute arsenic toxicity in mouse models

Cited by 158 publications

References 41 publications

The bumble bee microbiome increases survival of bees exposed to selenate toxicity

The bumble bee microbiome increases survival of bees exposed to selenate toxicity

Arsenic and the gastrointestinal tract microbiome

Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans

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