The gut microbiome in food allergy

Zhao, William; Ho, Hsi-en; Bunyavanich, Supinda

doi:10.1016/j.anai.2018.12.012

Cited by 110 publications

(88 citation statements)

References 65 publications

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“…Alternatively, cocktails of protective bacterial strains, including Clostridiales or Bacteroidales strains, such as B fragilis, could also be considered in protection from FA. Probiotic supplementation with Lactobacillus rhamnosus GG has been utilized during OIT for peanut allergy, and prebiotics, including oligofructose, acidic oligosaccharides, and long-chain inulin, in combination with the prebiotic Bifidobacterium breve M-16V, have also been administered in clinical trials for FA with some success [165][166][167][168][169][170][171][172][173].…”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

New Perspectives in Food Allergy

Martinis

Sirufo

Suppa

et al. 2020

IJMS

163

130

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The improvement of the knowledge of the pathophysiological mechanisms underlying the tolerance and sensitization to food antigens has recently led to a radical change in the clinical approach to food allergies. Epidemiological studies show a global increase in the prevalence of food allergy all over the world and manifestations of food allergy appear increasingly frequent also in elderly subjects. Environmental and nutritional changes have partly changed the epidemiology of allergic reactions to foods and new food allergic syndromes have emerged in recent years. The deepening of the study of the intestinal microbiota has highlighted important mechanisms of immunological adaptation of the mucosal immune system to food antigens, leading to a revolution in the concept of immunological tolerance. As a consequence, new prevention models and innovative therapeutic strategies aimed at a personalized approach to the patient affected by food allergy are emerging. This review focuses on these new perspectives and their practical implications in the management of food allergy, providing an updated view of this complex pathology.

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Section: Pharmacological Treatmentsmentioning

confidence: 99%

New Perspectives in Food Allergy

Martinis

Sirufo

Suppa

et al. 2020

IJMS

163

130

View full text Add to dashboard Cite

show abstract

“…Food intolerance due to dysbiosis is also reported by numerous authors [11][12][13]. Asthma is a condition frequently considered due to alterations suffered by the microbiota [14][15][16].…”

mentioning

confidence: 84%

Open Journal of Bacteriology

Tiburcio¹,

Ruiz²,

Reyes-López³

2019

Open J Bac

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The authors try to describe the Microbiota Diseases, like a process thatbrings together a number of conditions, caused by dysbiosis and that occur fudamentally in the devices and systems: Immunological, Gastrointestinal, Dermatological, Psychiatric, Neurological, Endocrinological and others. In order to draw attention to the need to strengthen ties of union between all those interested in the subject, to shorten resources, times and establish development criteria, this review is published. Without a doubt, it will make this Diseases, accepted, can be strengthened and direct talents for the benefi t of the millions of human beings affected by this problem.

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“…33 Thus, it is not surprising that several investigators have reported an association between decreased gut microbial diversity, and in some cases specific microbial signatures, and food allergy. 34 Two recent studies employed fecal microbial transplants (FMT) from humans into germ-free mice and compared outcomes when the FMT was derived from foodallergic or healthy subjects. Feehley et al 28 found that FMT from healthy infants, but not from infants with cow's milk allergy, could suppress immunoglobulin E (IgE) induction and anaphylaxis in a model using b-lactoglobulin sensitization and challenge.…”

Section: Recent Insights Into Food Allergymentioning

confidence: 99%

α-Gal and other recent findings that have informed our understanding of anaphylaxis

Wilson

Platts-Mills

2020

Annals of Allergy, Asthma & Immunology

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A B S T R A C TObjective: To summarize the current understanding of anaphylaxis, with an emphasis on major findings that have been reported within the last 10 years. Data Sources: Queries relating to anaphylaxis, immunoglobulin E (IgE), and mast cells were conducted with PubMed and Google Scholar, searching for primary articles and review papers. Study Selections: We focused on articles written in English and which were reported in major allergy and immunology journals. Results: Anaphylaxis represents an extreme manifestation of a form of allergic immunity that appears to have evolved to protect against "toxic" threats that present at skin and mucosal barriers. The factors that have contributed to a rise in anaphylaxis are increasingly appreciated to relate to changes in hygiene and microbial ecology that have occurred with industrialization. Induction of allergen-specific IgG4 is often part of the allergic response and is associated with protection against anaphylaxis. The recognition of the a-Gal syndrome suggests that carbohydrates can be epitopes that are relevant to anaphylaxis and that IgEmediated reactions do not always occur "immediately." Conclusion: Our understanding of anaphylaxis has advanced significantly over the past 10 years. It is anticipated that ongoing research will build on this foundation to further advance our knowledge of anaphylaxis and also translate into clinically meaningful therapies.Ó 2019 Published by Elsevier Inc. on behalf of American College of Allergy, Asthma & Immunology. InstructionsCredit can now be obtained, free for a limited time, by reading the review article and completing all activity components. Please note the instructions listed below:Review the target audience, learning objectives and all disclosures.Complete the pre-test.Read the article and reflect on all content as to how it may be applicable to your practice.Complete the post-test/evaluation and claim credit earned. At this time, physicians will have earned up to 1.0 AMA PRA Category 1 Credit TM . Minimum passing score on the post-test is 70%. Overall Purpose Participants will be able to demonstrate increased knowledge of the clinical treatment of allergy/asthma/immunology and how new information can be applied to their own practices.Disclosures: TPM has a patent on an IgE assay to a-Gal and has received assay support from Phadia/Thermo-Fisher; JW has received research support from Phadia/Thermo-Fisher.

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The gut microbiome in food allergy

Cited by 110 publications

References 65 publications

New Perspectives in Food Allergy

New Perspectives in Food Allergy

Open Journal of Bacteriology

α-Gal and other recent findings that have informed our understanding of anaphylaxis

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