The gut microbiome and psycho-cognitive traits

Vernice, Nicholas A.; Shah, Neal; Lam, Eric; Herd, Pamela; Reiss, Allison B.; Kasselman, Lora J.

doi:10.1016/bs.pmbts.2020.08.014

Cited by 3 publications

(2 citation statements)

References 80 publications

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“…Some authors [13,[198][199][200] highlighted a significant role in the etiology of BPD for early developmental processes, including prenatal stress and maternal dysbiosis, with effects mediated through the infant gut microbiome and its influence on amygdala development. The amygdala has an important role in the cortex and brain connectivity that may explain some of the abnormalities present in BPD, such as excessive activation of the amygdala towards negative emotions and reduced frontal regulation [201].…”

Section: Personality Disordersmentioning

confidence: 99%

Nutraceuticals in Psychiatric Disorders: A Systematic Review

Bozzatello,

Novelli,

Montemagni

et al. 2024

IJMS

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Correct nutrition and diet are directly correlated with mental health, functions of the immune system, and gut microbiota composition. Diets with a high content of some nutrients, such as fibers, phytochemicals, and short-chain fatty acids (omega-3 fatty acids), seem to have an anti-inflammatory and protective action on the nervous system. Among nutraceuticals, supplementation of probiotics and omega-3 fatty acids plays a role in improving symptoms of several mental disorders. In this review, we collect data on the efficacy of nutraceuticals in patients with schizophrenia, autism spectrum disorders, major depression, bipolar disorder, and personality disorders. This narrative review aims to provide an overview of recent evidence obtained on this topic, pointing out the direction for future research.

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Section: Personality Disordersmentioning

confidence: 99%

Nutraceuticals in Psychiatric Disorders: A Systematic Review

Bozzatello,

Novelli,

Montemagni

et al. 2024

IJMS

View full text Add to dashboard Cite

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“…Another notable Korean study found that disbalance in gut microbiota and neuroticism may have a close association, and this relationship can be exploited for potential microbiome-based interventions [359]. Many other studies have validated similar ideas [360][361][362][363][364][365][366][367][368]. The subject of primary inoculation and cultural practices needs more basic research for the proper building of the evidence, but the first bricks are laid.…”

Section: Microbiome Behavior Depression and Personalitymentioning

confidence: 99%

Varied Composition and Underlying Mechanisms of Gut Microbiome in Neuroinflammation

et al. 2022

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The human gut microbiome has been implicated in a host of bodily functions and their regulation, including brain development and cognition. Neuroinflammation is a relatively newer piece of the puzzle and is implicated in the pathogenesis of many neurological disorders. The microbiome of the gut may alter the inflammatory signaling inside the brain through the secretion of short-chain fatty acids, controlling the availability of amino acid tryptophan and altering vagal activation. Studies in Korea and elsewhere highlight a strong link between microbiome dynamics and neurocognitive states, including personality. For these reasons, re-establishing microbial flora of the gut looks critical for keeping neuroinflammation from putting the whole system aflame through probiotics and allotransplantation of the fecal microbiome. However, the numerosity of the microbiome remains a challenge. For this purpose, it is suggested that wherever possible, a fecal microbial auto-transplant may prove more effective. This review summarizes the current knowledge about the role of the microbiome in neuroinflammation and the various mechanism involved in this process. As an example, we have also discussed the autism spectrum disorder and the implication of neuroinflammation and microbiome in its pathogenesis.

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