The Gut Microbiome and Liver Disease

Yu, Le-Xing; Bajaj, Jasmohan S.; Schwabe, Robert F.

doi:10.1002/9781119436812.ch84

Cited by 2 publications

(2 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mono-and bidirectional communication pathways, such as the gut-skin axis or the gut-liver axis, have been described in humans and are thought to be strongly involved in the development of diseases [23,70,71]. For example, the gut-liver axis is now the subject of much speculation in relation to human health [18]. Recently, modification of the gut microbiota was shown to alter the tightness of the epithelial barrier, allowing the transfer of microbes and various other metabolites into the blood and triggering the inflammation of liver tissue [64,65].…”

Section: Discussionmentioning

confidence: 99%

“…To date, most studies investigating marine microbiomes have examined a single biological compartment at a time, often the digestive tract or the skin mucus, but the microbiome of other essential organs such as the liver has never been investigated, despite the central role of this organ in metabolic and immune functions within the organism [16]. Moreover, recent findings of bacterial genes in the human liver suggest that this organ could be a neglected bacterial habitat in vertebrates [17,18].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fishing for the Bacteriome of Tropical Tuna

Gadoin

Desnues

D’Orbcastel

et al. 2021

Preprint

View full text Add to dashboard Cite

Background : Although tunas represent a significant part of the global fish economy and a major nutritional resource worldwide, their consumption poses a risk of food poisoning through the development of particular bacterial pathogens. However, their microbiome still remains poorly documented. Here, we conducted a multi-compartmental analysis of the taxonomic composition of the bacterial communities inhabiting the gut, skin and liver of two most consumed tropical tuna species (skipjack and yellowfin), from individuals caught in the Atlantic and Indian oceans. Results : Our results revealed that the composition of the microbiome was independent of fish sex, regardless of the species and ocean considered. Instead, the main determinants were (i) tuna species for the gut and(ii) sampling site for the skin mucus layer, and (iii) a combination of both parameters for the liver. Interestingly, only 4.5% of all ASVs were shared by the three compartments, raising numerous questions about the circulation of microorganisms within the tuna body. Our results also revealed the presence of a unique and diversified bacterial assemblage within the liver, comprising a substantial proportion of histamine-producing bacteria, well known for their potential pathogenicity and their contribution to fish poisoning cases. Conclusions : These results indicate that the tuna liver is an unexplored microbial niche whose role in the health of both the host and consumers remains to be elucidated.

show abstract