The gut microbiome and cognition in Parkinson’s disease: a systematic review

Grant, Hayley; Anderton, Ryan S.; Gasson, Natalie; Lawrence, Blake J.

doi:10.1080/1028415x.2022.2110189

Cited by 4 publications

(3 citation statements)

References 48 publications

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“…Modifications of the compositions of the gut microbiota have been identified in numerous pathologies and the different potential mechanisms of action have been described in a significant number of narrative reviews mostly focusing on Alzheimer's disease (AD) [11][12][13][14][15][16], Parkinson's disease (PD) [17][18][19][20][21][22][23], and multiple sclerosis (MS) [24][25][26][27]. Changes in the gut microbiota have also been found in stroke [28,29] and amyotrophic lateral sclerosis (ALS) [30,31].…”

Section: Introductionmentioning

confidence: 99%

What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review

Bonnechère

Amin

Duijn

2022

IJMS

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There is a growing body of evidence highlighting there are significant changes in the gut microbiota composition and relative abundance in various neurological disorders. We performed a systematic review of the different microbiota altered in a wide range of neurological disorders (Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis, and stroke). Fifty-two studies were included representing 5496 patients. At the genus level, the most frequently involved microbiota are Akkermansia, Faecalibacterium, and Prevotella. The overlap between the pathologies was strongest for MS and PD, sharing eight genera (Akkermansia, Butyricicoccus, Bifidobacterium, Coprococcus, Dorea, Faecalibacterium, Parabacteroides, and Prevotella) and PD and stroke, sharing six genera (Enterococcus, Faecalibacterium, Lactobacillus, Parabacteroides, Prevotella, and Roseburia). The identification signatures overlapping for AD, PD, and MS raise the question of whether these reflect a common etiology or rather common consequence of these diseases. The interpretation is hampered by the low number and low power for AD, ALS, and stroke with ample opportunity for false positive and false negative findings.

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Section: Introductionmentioning

confidence: 99%

What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review

Bonnechère

Amin

Duijn

2022

IJMS

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“…Both diabetes and prediabetes also may negatively affect cognitive function in PD, with a significant interaction of diabetes status and age, but not with duration of PD [ 88 ]. Gut microbiome composition (reduced short-chain fatty acid-producing bacteria) has been associated with PD-CI [ 89 ]. Both increased uric acid levels and altered glomerular filtration rate with lower cerebrospinal fluid (CSF) amyloid-β (Aβ) and αSyn, and higher neurofilament light (NfL) in serum are associated with CI in PD [ 90 , 91 ].…”

Section: Risk Factors Of CI In Pdmentioning

confidence: 99%

Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks

Jellinger

2023

IJMS

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Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD) that poses a severe burden on the patients and caregivers, yet relatively little is known about its pathobiology. Cognitive deficits are evident throughout the course of PD, with around 25% of subtle cognitive decline and mild CI (MCI) at the time of diagnosis and up to 83% of patients developing dementia after 20 years. The heterogeneity of cognitive phenotypes suggests that a common neuropathological process, characterized by progressive degeneration of the dopaminergic striatonigral system and of many other neuronal systems, results not only in structural deficits but also extensive changes of functional neuronal network activities and neurotransmitter dysfunctions. Modern neuroimaging studies revealed multilocular cortical and subcortical atrophies and alterations in intrinsic neuronal connectivities. The decreased functional connectivity (FC) of the default mode network (DMN) in the bilateral prefrontal cortex is affected already before the development of clinical CI and in the absence of structural changes. Longitudinal cognitive decline is associated with frontostriatal and limbic affections, white matter microlesions and changes between multiple functional neuronal networks, including thalamo-insular, frontoparietal and attention networks, the cholinergic forebrain and the noradrenergic system. Superimposed Alzheimer-related (and other concomitant) pathologies due to interactions between α-synuclein, tau-protein and β-amyloid contribute to dementia pathogenesis in both PD and dementia with Lewy bodies (DLB). To further elucidate the interaction of the pathomechanisms responsible for CI in PD, well-designed longitudinal clinico-pathological studies are warranted that are supported by fluid and sophisticated imaging biomarkers as a basis for better early diagnosis and future disease-modifying therapies.

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“…[5][6][7][8] Significant microbiota taxonomic differences and elevated proteolytic metabolites were strongly associated with GI function; for example, stool consistency and constipation were found in PD patients. 9,10 Recently, increasing evidences have indicated that gut microbiota disturbance is involved in the clinical phenotypes of PD and its pathogenesis via the braingut-microbiota axis. [11][12][13] In view of this correlation, microbial therapy might be a possible approach for treating PD.…”

Section: Introductionmentioning

confidence: 99%

The protective role of microbiota in the prevention of MPTP/P-induced Parkinson's disease by resveratrol

Jiang

et al. 2023

Food Funct.

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The gut microbiome and cognition in Parkinson’s disease: a systematic review

Cited by 4 publications

References 48 publications

What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review

What Are the Key Gut Microbiota Involved in Neurological Diseases? A Systematic Review

Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks

The protective role of microbiota in the prevention of MPTP/P-induced Parkinson's disease by resveratrol

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