The Gut Microbiome Affects Human Mood and Behavior

Villa, Tomás G.; Sánchez-Pérez, Alicia

doi:10.1007/978-3-030-77595-7_22

Cited by 3 publications

(3 citation statements)

References 140 publications

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“…The former can initiate blood coagulation (plasma-free clotting) [ 50 ], whereas the latter can cleave substance P and chemokines [ 51 ]. The bulk of the human microbiota inhabits the gastrointestinal tract (GIT), where it modulates diverse aspects such as insulin signaling, behavior, and allergy [ 52 , 53 , 54 , 55 ]. Similar to EVs that play a role in the host’s intercellular communication, microbiota release outer membrane vesicles (OMVs) that play a role in host–microbiota communication [ 56 ].…”

Section: Biology Of Extracellular Vesiclesmentioning

confidence: 99%

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

Al-Jipouri,

Eritja,

Bozic

2023

IJMS

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Extracellular vesicles (EVs) are nanoparticles released from various cell types that have emerged as powerful new therapeutic option for a variety of diseases. EVs are involved in the transmission of biological signals between cells and in the regulation of a variety of biological processes, highlighting them as potential novel targets/platforms for therapeutics intervention and/or delivery. Therefore, it is necessary to investigate new aspects of EVs’ biogenesis, biodistribution, metabolism, and excretion as well as safety/compatibility of both unmodified and engineered EVs upon administration in different pharmaceutical dosage forms and delivery systems. In this review, we summarize the current knowledge of essential physiological and pathological roles of EVs in different organs and organ systems. We provide an overview regarding application of EVs as therapeutic targets, therapeutics, and drug delivery platforms. We also explore various approaches implemented over the years to improve the dosage of specific EV products for different administration routes.

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Section: Biology Of Extracellular Vesiclesmentioning

confidence: 99%

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

Al-Jipouri,

Eritja,

Bozic

2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Recent studies suggest that the current high incidence of food allergies is most likely due to the changes in the GI microbial populations generated by our "modern eating habits", particularly in developed nations. In fact, the microorganisms that inhabit our bodies, our gut microbiota, are now envisioned as "a second brain", that uses chemical mediators (often generated by the gut microbiota) to modulate distal organs, even having an effect on our mood and behavior [2]. The review article by Ipci and co-workers in 2017 [103] provides a currently accepted view on the possible mechanisms involved in the trigger and modulation of allergic diseases by the microbiota.…”

Section: Gut Microorganisms and Allergiesmentioning

confidence: 99%

“…The gut microbiota is currently considered a "hidden metabolic organ", capable of controlling distal human tissues via the release of chemical mediators [1,2]. Even the earliest known humans understood that while some foodstuffs produced beneficial effects on their bodies, others could be detrimental to their health.…”

Section: Introductionmentioning

confidence: 99%

The Role of the Gallbladder, the Intestinal Barrier and the Gut Microbiota in the Development of Food Allergies and Other Disorders

Abril

Villa

Sánchez-Pérez

et al. 2022

IJMS

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The microbiota present in the gastrointestinal tract is involved in the development or prevention of food allergies and autoimmune disorders; these bacteria can enter the gallbladder and, depending on the species involved, can either be benign or cause significant diseases. Occlusion of the gallbladder, usually due to the presence of calculi blocking the bile duct, facilitates microbial infection and inflammation, which can be serious enough to require life-saving surgery. In addition, the biliary salts are secreted into the intestine and can affect the gut microbiota. The interaction between the gut microbiota, pathogenic organisms, and the human immune system can create intestinal dysbiosis, generating a variety of syndromes including the development of food allergies and autoimmune disorders. The intestinal microbiota can aggravate certain food allergies, which become severe when the integrity of the intestinal barrier is affected, allowing bacteria, or their metabolites, to cross the intestinal barrier and invade the bloodstream, affecting distal body organs. This article deals with health conditions and severe diseases that are either influenced by the gut flora or caused by gallbladder obstruction and inflammation, as well as putative treatments for those illnesses.

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Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

Luqman,

He,

Hassan

et al. 2024

Front. Psychiatry

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Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in the CNS by regulating it through chemical, immunological, hormonal, and neurological processes. Various studies have found a significant bidirectional link between the brain and the gut, emphasizing the onset of depression therapies. The biological and molecular processes underlying depression and microbiota are required, as the bidirectional association may represent a novel study. However, profound insights into the stratification and diversity of the gut microbiota are still uncommon. This article investigates the emerging evidence of a bacterial relationship between the gut and the brain’s neurological system and its potential pathogenicity and relevance. The interplay of microbiota, immune system, nervous system neurotransmitter synthesis, and neuroplasticity transitions is also widely studied. The consequences of stress, dietary fibers, probiotics, prebiotics, and antibiotics on the GB axis are being studied. Multiple studies revealed the processes underlying this axis and led to the development of effective microbiota-based drugs for both prevention and treatment. Therefore, the results support the hypothesis that gut microbiota influences depression and provide a promising area of research for an improved knowledge of the etiology of the disease and future therapies.

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The Gut Microbiome Affects Human Mood and Behavior

Cited by 3 publications

References 140 publications

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

Unraveling the Multifaceted Roles of Extracellular Vesicles: Insights into Biology, Pharmacology, and Pharmaceutical Applications for Drug Delivery

The Role of the Gallbladder, the Intestinal Barrier and the Gut Microbiota in the Development of Food Allergies and Other Disorders

Mood and microbes: a comprehensive review of intestinal microbiota’s impact on depression

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