The Gut Microbiome: A novel player in response to systemic treatment for Breast Cancer

Bruce, Eilidh; Makaranka, Stanislau; Urquhart, Gordon; Elsberger, Beatrix

doi:10.1016/j.ejso.2022.11.228

Cited by 1 publication

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“…A murine study demonstrated that Helicobacter hepaticus in the gut mediates the neutrophil response to breast cancer, thereby accelerating its progression [ 163 ]. As a result of chronic inflammation and epigenetic deregulation, gut bacteria can further facilitate BC development [ 164 ].…”

Section: Modulation Of the Microbiota Through Diet As A Potential Adj...mentioning

confidence: 99%

“…In addition, there is evidence that the microbiome of the gut influences the degree of response to immune checkpoint inhibitors CTLA4 and PD-L1/PD-1 [ 166 ]. Researchers have observed that mice with specific microbiota (e.g., Akkermansia and Bifidobacterium ) respond better to anti-PD-L1 therapy and that patients with Bacteroidetes have a greater resistance to immune checkpoint inhibitor-induced colitis [ 164 , 167 ].…”

Section: Modulation Of the Microbiota Through Diet As A Potential Adj...mentioning

confidence: 99%

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The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer

Plaza‐Díaz

Álvarez‐Mercado

2023

Metabolites

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The most common cancer in women is breast cancer, which is also the second leading cause of death in this group. It is, however, important to note that some women will develop or will not develop breast cancer regardless of whether certain known risk factors are present. On the other hand, certain compounds are produced by bacteria in the gut, such as short-chain fatty acids, secondary bile acids, and other metabolites that may be linked to breast cancer development and mediate the chemotherapy response. Modeling the microbiota through dietary intervention and identifying metabolites directly associated with breast cancer and its complications may be useful to identify actionable targets and improve the effect of antiangiogenic therapies. Metabolomics is therefore a complementary approach to metagenomics for this purpose. As a result of the combination of both techniques, a better understanding of molecular biology and oncogenesis can be obtained. This article reviews recent literature about the influence of bacterial metabolites and chemotherapy metabolites in breast cancer patients, as well as the influence of diet.

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Section: Modulation Of the Microbiota Through Diet As A Potential Adj...mentioning

confidence: 99%

Section: Modulation Of the Microbiota Through Diet As A Potential Adj...mentioning

confidence: 99%

The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer

Plaza‐Díaz

Álvarez‐Mercado

2023

Metabolites

View full text Add to dashboard Cite

show abstract

The Gut Microbiome: A novel player in response to systemic treatment for Breast Cancer

Cited by 1 publication

References 0 publications

The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer

The Interplay between Microbiota and Chemotherapy-Derived Metabolites in Breast Cancer

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