The Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases

Fogelson, Kelly; Dorrestein, Pieter C.; Zarrinpar, Amir; Knight, Rob

doi:10.1053/j.gastro.2023.02.022

Cited by 29 publications

(20 citation statements)

References 217 publications

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“…BAs are produced in the liver, which has a close connection with a variety of metabolic diseases. 27 The causality has not been fully clarified, but BAs and their receptors can regulate the neurological functions of the central nervous system (CNS). 9 In general, the classic pathway in the liver is mediated by the rate-limiting enzyme CYP7A1, while the alternative pathway is initiated by CYP27A1.…”

Section: Discussionmentioning

confidence: 99%

Water extract of goji berries improves neuroinflammation induced by a high-fat and high-fructose diet based on the bile acid-mediated gut–brain axis pathway

Dong,

Huang,

Shu

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Water extract of goji berries improves neuroinflammation induced by a high-fat and high-fructose diet based on the bile acid-mediated gut–brain axis pathway

Dong,

Huang,

Shu

et al. 2023

Food Funct.

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“…The gut microbiota has been found to play a critical role in modifying host metabolism as well as BAs metabolism. , Thus, we further profiled the compositional alteration of gut microbiota in response to different high-calorie diets based on the V3–V4 regions of bacterial 16S rRNA gene extracted from cecal content. First of all, the Unweighted UniFrac principal coordinate analysis (PCoA) showed that HFD groups had dramatically different patterns of gut microbiota with Con and HSD groups.…”

Section: Resultsmentioning

confidence: 99%

High Fat Diet and High Sucrose Intake Divergently Induce Dysregulation of Glucose Homeostasis through Distinct Gut Microbiota-Derived Bile Acid Metabolism in Mice

He,

Gao,

Hong

et al. 2023

J. Agric. Food Chem.

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A high calorie diet such as excessive fat and sucrose intake is always accompanied by impaired glucose homeostasis such as T2DM (type 2 diabetes mellitus). However, it remains unclear how fat and sucrose individually affect host glucose metabolism. In this study, mice were fed with high fat diet (HFD) or 30% sucrose in drinking water (HSD) for 24 weeks, and glucose metabolism, gut microbiota composition, as well as bile acid (BA) profile were investigated. In addition, the functional changes of HFD or HSD-induced gut microbiota were further verified by fecal microbiota transplantation (FMT) and ex vivo culture of gut bacteria with BAs. Our results showed that both HFD and HSD caused dysregulated lipid metabolism, while HFD feeding had a more severe effect on impaired glucose homeostasis, accompanied by reduced hyocholic acid (HCA) levels in all studied tissues. Meanwhile, HFD had a more dramatic influence on composition and function of gut microbiota based on α diversity indices, β diversity analysis, as well as the abundance of secondary BA producers than HSD. In addition, the phenotypes of impaired glucose homeostasis and less formation of HCA caused by HFD can be transferred to recipient mice by FMT. Ex vivo culture with gut bacteria and BAs revealed HFD-altered gut bacteria produced less HCA than HSD, which might closely associate with reduced relative abundance of C7 epimerase-coding bacteria g_norank/unclassif ied_f_Eggerthellaceae and bile salt hydrolase-producing bacteria Lactobacillus and Bif idobacterium in HFD group. Our findings revealed that the divergent effects of different high-calorie diets on glucose metabolism may be due to the gut microbiota-mediated generation and metabolism of BAs, highlighting the importance of dietary management in T2DM.

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“…[53,54] We also found that TBA was elevated in the disease group, whereas TBIL, DBIL and IBIL were the opposite and that HDL-C was decreased in the disease group. Previous studies have shown that BAs are involved in metabolism and immune regulation, while HDL-C has cardiovascular and cerebrovascular protective effects [44,45,55]. In short, the clinical indicators reveal alterations in the immunity and metabolism of the organism.…”

Section: Discussionmentioning

confidence: 99%

Multiomics analysis reveals gut profiles in patients with different brain tumors

Wang,

Zhou,

Zhao

et al. 2023

Preprint

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Background Numerous close relationships between the gut microbiota and various cancers have been described, and several studies suggest that the gut microbiota can influence the central nervous system (CNS), but the relationship between the intestinal microbiome and brain tumors is unclear. Furthermore, the role of action of the gut microbiota on brain tumors has not been well understood, especially in the CNS, which has been considered an immune-privileged organ due to the presence of the blood-brain barrier. Results In the present work, we systematically compared the gut microbiome and metabolite alterations in patients with a brain tumor, including patients with meningioma (MEG), glioma and brain metastasis (BM), with those of healthy controls (HCs) using faecal metagenomics and metabolomics, and used this in relation to clinical indicators to explore their possible causative mechanisms in the disease. In the disease group, bacterial abundance was altered, showing a significant decrease in Gram-positive bacteria such as Lachnospiraceae and a substantial increase in Gram-negative bacteria such as Enterobacteriaceae, while lipopolysaccharide‒associated pathways were also enriched. Additionally, metabolites were changed: most amino acid and fatty acid metabolites increased, while bile acids (BAs) and carbohydrates decreased. However, the differences in bacteria and metabolites between the disease groups were less than those between the HCs. Furthermore, a variety of immune-related clinical indicators, bacteria, metabolites and pathways were significantly altered in the disease groups. Finally, markers based on bacterial flora and metabolites were effective in differentiating the disease groups from the HCs. Conclusions The multiomics data from this study revealed that dysbiosis and metabolic abnormalities were present in the gut of patients with brain tumors. At the same time, host immune abnormalities may be associated with dysbiosis and may lead to tumour development and progression through inflammatory, immune, and metabolic interactions; these altered microbiome-metabolome-host interactions may help explain the pathogenesis of brain tumors, and provide new ideas for the prevention and treatment of brain tumors. The microbiome and its derived metabolites are a promising noninvasive tool for the accurate detection and differentiation of patients with different brain tumors.

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The Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases

Cited by 29 publications

References 217 publications

Water extract of goji berries improves neuroinflammation induced by a high-fat and high-fructose diet based on the bile acid-mediated gut–brain axis pathway

Water extract of goji berries improves neuroinflammation induced by a high-fat and high-fructose diet based on the bile acid-mediated gut–brain axis pathway

High Fat Diet and High Sucrose Intake Divergently Induce Dysregulation of Glucose Homeostasis through Distinct Gut Microbiota-Derived Bile Acid Metabolism in Mice

Multiomics analysis reveals gut profiles in patients with different brain tumors

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