The Gut Commensal Escherichia coli Aggravates High-Fat-Diet-Induced Obesity and Insulin Resistance in Mice

Ju, Tingting; Bourrie, Benjamin C. T.; Forgie, Andrew J.; Pepin, Deanna M.; Tollenaar, Stephanie; Sergi, Consolato; Willing, Benjamin P.

doi:10.1128/aem.01628-22

Cited by 11 publications

(10 citation statements)

References 55 publications

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“…However, the class Clostridia plays a conflicting role because it was found to have a decreased abundance in NAFLD progression induced by a Western diet [ 40 ]. At the family level, the enrichment of Enterobacteriaceae induced by a HFD has been correlated with impaired glucose homeostasis [ 41 ] and was herein associated with OVX-induced NAFLD. The genus Parabacteroides content was reported to be lower in postmenopausal than in premenopausal women [ 42 ], yet we found it to be higher in the OVX group, and other research has reported that Parabacteroides was enriched in early hepatocellular carcinoma (HCC) [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

Tian,

Xie,

Hong

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

Tian,

Xie,

Hong

et al. 2024

Heliyon

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“…E. coli was found to be predictive of the development of insulin resistance in postmenopausal obese Caucasian females in Sweden ( 149 ). In a HFD-fed mouse model of obesity, E. coli significantly increased body weight and adiposity, and induced impaired glucose tolerance ( 150 ). Therapeutically, in a human randomized trial, paradoxically, the investigators found that metformin treatment significantly increased amplicon sequence of E. coli variants ( 65 ).…”

Section: Bacteria Closely Related To Obesity and Diabetesmentioning

confidence: 99%

“…The increase of the relative abundance in E. coli , was also observed in patients after VGB or RYGB ( 95 , 97 ). However, colonization of E. coli in germ-free mice led to increased inflammation in liver, adipose tissue and intestinal tissue under a HFD regimen ( 150 ). The role of E. coli in obesity and/or type 2 diabetes is debatable as there are contradictory findings; thus, we need to further clarify the mechanism of action of E. coli in obesity and diabetes in future research.…”

Section: Bacteria Closely Related To Obesity and Diabetesmentioning

confidence: 99%

Gut microbiota and therapy for obesity and type 2 diabetes

Zhang,

Wang,

Huang

et al. 2024

Front. Endocrinol.

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There has been a major increase in Type 2 diabetes and obesity in many countries, and this will lead to a global public health crisis, which not only impacts on the quality of life of individuals well but also places a substantial burden on healthcare systems and economies. Obesity is linked to not only to type 2 diabetes but also cardiovascular diseases, musculoskeletal disorders, and certain cancers, also resulting in increased medical costs and diminished quality of life. A number of studies have linked changes in gut in obesity development. Dysbiosis, a deleterious change in gut microbiota composition, leads to altered intestinal permeability, associated with obesity and Type 2 diabetes. Many factors affect the homeostasis of gut microbiota, including diet, genetics, circadian rhythms, medication, probiotics, and antibiotics. In addition, bariatric surgery induces changes in gut microbiota that contributes to the metabolic benefits observed post-surgery. Current obesity management strategies encompass dietary interventions, exercise, pharmacotherapy, and bariatric surgery, with emerging treatments including microbiota-altering approaches showing promising efficacy. While pharmacotherapy has demonstrated significant advancements in recent years, bariatric surgery remains one of the most effective treatments for sustainable weight loss. However, access to this is generally limited to those living with severe obesity. This underscores the need for non-surgical interventions, particularly for adolescents and mildly obese patients. In this comprehensive review, we assess longitudinal alterations in gut microbiota composition and functionality resulting from the two currently most effective anti-obesity treatments: pharmacotherapy and bariatric surgery. Additionally, we highlight the functions of gut microbiota, focusing on specific bacteria, their metabolites, and strategies for modulating gut microbiota to prevent and treat obesity. This review aims to provide insights into the evolving landscape of obesity management and the potential of microbiota-based approaches in addressing this pressing global health challenge.

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“…At the same time, these changes were observed to reduce microbial diversity and increase the Firmicutes/Bacteroidetes ratio. Further, at the genus level, saturated fats have been shown to relatively increase gram-negative bacterium including Fusobacterium, Tyzzerella, Anaerotruncus, Lachnospiraceae, Eisenbergiella and Escherichia [126,127,129]. In turn, the production of lipopolysaccharides by these gut bacteria promotes a pro-inflammatory state leading to metabolic endotoxemia and chronic inflammation.…”

Section: Saturated Fatsmentioning

confidence: 99%

Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake

Hamamah,

Amin,

Al-Kassir

et al. 2023

Nutrients

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Obesity is a multifactorial disease that continues to increase in prevalence worldwide. Emerging evidence has shown that the development of obesity may be influenced by taxonomic shifts in gut microbiota in response to the consumption of dietary fats. Further, these alterations in gut microbiota have been shown to promote important changes in satiation signals including gut hormones (leptin, ghrelin, GLP-1, peptide YY and CCK) and orexigenic and anorexigenic neuropeptides (AgRP, NPY, POMC, CART) that influence hyperphagia and therefore obesity. In this review, we highlight mechanisms by which gut microbiota can influence these satiation signals both locally in the gastrointestinal tract and via microbiota-gut-brain communication. Then, we describe the effects of dietary interventions and associated changes in gut microbiota on satiety signals through microbiota-dependent mechanisms. Lastly, we present microbiota optimizing therapies including prebiotics, probiotics, synbiotics and weight loss surgery that can help restore beneficial gut microbiota by enhancing satiety signals to reduce hyperphagia and subsequent obesity. Overall, a better understanding of the mechanisms by which dietary fats induce taxonomical shifts in gut microbiota and their impact on satiation signaling pathways will help develop more targeted therapeutic interventions in delaying the onset of obesity and in furthering its treatment.

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The Gut Commensal Escherichia coli Aggravates High-Fat-Diet-Induced Obesity and Insulin Resistance in Mice

Cited by 11 publications

References 55 publications

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

Gut microbiota and therapy for obesity and type 2 diabetes

Dietary Fat Modulation of Gut Microbiota and Impact on Regulatory Pathways Controlling Food Intake

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