2019
DOI: 10.2174/1570161116666181005125459
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The Gulf Familial Hypercholesterolemia Registry (Gulf FH): Design, Rationale and Preliminary Results

Abstract: Aim: To determine the prevalence, genetic characteristics, current management and outcomes of familial hypercholesterolaemia (FH) in the Gulf region. Methods: Adult (18-70 years) FH patients were recruited from 9 hospitals and centres across 5 Arabian Gulf countries. The study was divided into 4 phases and included patients from 3 different categories. In phase 1, suspected FH patients (category 1) were collected according to the lipid profile and clinical data obtained through hospital record systems. In ph… Show more

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Cited by 28 publications
(25 citation statements)
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“…We have reported recently a high prevalence of familial hypercholesterolemia in Saudi Arabia and the rest of the Arabian Gulf countries. [73] In conclusion, the PURE-Saudi is the first population cohort study in Saudi Arabia. It demonstrated the continued high prevalence of CVD risk factors in the adult Saudi population despite over a decade of several population surveys, and some of these factors were even more prevalent in the rural than the urban population.…”
Section: Discussionmentioning
confidence: 92%
“…We have reported recently a high prevalence of familial hypercholesterolemia in Saudi Arabia and the rest of the Arabian Gulf countries. [73] In conclusion, the PURE-Saudi is the first population cohort study in Saudi Arabia. It demonstrated the continued high prevalence of CVD risk factors in the adult Saudi population despite over a decade of several population surveys, and some of these factors were even more prevalent in the rural than the urban population.…”
Section: Discussionmentioning
confidence: 92%
“…Lastly, we cannot exclude the role of genetic predisposition to such high prevalence of CVD risk factors, which could be related to the high consanguinity in the Saudi population. We have reported recently a high prevalence of familial hypercholesterolemia in Saudi Arabia and the rest of the Arabian Gulf countries [73].…”
Section: Discussionmentioning
confidence: 93%
“…Studies in other global regions not covered in this review are underway or beginning to examine the clinical and actionable outcomes discussed herein, to ascertain the clinical and public health utility of FH genetic testing. For example, the gulf familial hypercholesterolemia registry study is occurring among an adult population within the Arabian Gulf region where the prevalence of probable and definite FH (per DLCN criteria) is 1/232 [54]. Such studies will contribute to the rich and growing body of evidence showing how FH genetic testing might lead to overall favorable public health outcomes that could help address the current and growing global epidemic of cardiovascular disease.…”
Section: Discussionmentioning
confidence: 99%