1984
DOI: 10.4269/ajtmh.1984.33.1251
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The Guinea Pig Model for Argentine Hemorrhagic Fever *

Abstract: Guinea pigs infected by the peripheral route with the XJ pathogenic strain of Junin virus showed viscerotropism mainly in reticulo-phagocytic rich organs. By immunofluorescence, heavy infection of reticular-phagocytic cells was demonstrated, supporting the leading role of these cell types. Absence of neurotropism was demonstrated by the inability to recover infectious virus, as well as the absence of antigens, immunoglobulins, or 3rd component of complement deposits, in cells, vessels, or meninges. The correla… Show more

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Cited by 22 publications
(8 citation statements)
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“…These findings strongly suggest that cell-mediated immunity is markedly impaired in the guinea pig infected with the XJ strain (11). These animals died without detectable CF, neutralizing or IF antibodies (69). High levels of interferon were also detected in infected guinea pigs (30).…”
Section: Studies With the Xj Prototype Strain In Guinea Figs And Primmentioning
confidence: 80%
See 1 more Smart Citation
“…These findings strongly suggest that cell-mediated immunity is markedly impaired in the guinea pig infected with the XJ strain (11). These animals died without detectable CF, neutralizing or IF antibodies (69). High levels of interferon were also detected in infected guinea pigs (30).…”
Section: Studies With the Xj Prototype Strain In Guinea Figs And Primmentioning
confidence: 80%
“…No virus can be recovered from brain unless a viral strain highly passaged in guinea pig is used (69). In this case, an enhanced neurotropism, with neurologic signs, viral isolation and antigen detection in brain has been reported after peripheral inoculation, thus suggesting selection of viral subpopulations with high neurotropism (70).…”
Section: Studies With the Xj Prototype Strain In Guinea Figs And Primmentioning
confidence: 84%
“…3). Within (15,16), with peak geometric mean titers reaching 3.49 and 3.46 log1o PFU/ml on day 17 postinoculation in serum and throat swabs, respectively.…”
Section: Resultsmentioning
confidence: 99%
“…Guinea pigs (7,17,25), marmosets (5,22), and rhesus macaques (6,15,16) have been shown to be useful models for studying issues related to the pathogenesis of AHF. Recently, ribavirin (1--D-ribofuranosyl-1,2,4-triazole-3-carboxyamide), a broad-spectrum antiviral compound with significant activity in vitro and in vivo against a variety of viruses that cause hemorrhagic fever syndromes in humans, was evaluated for its therapeutic efficacy in guinea pigs infected with Junin virus (12).…”
mentioning
confidence: 99%
“…Guinea pig infection models have been described for LASV, JUNV and Guanarito virus (GTOV) [28], [29], [30], [31], and are the best-suited small animal models to further investigate the activity of favipiravir. Due to the maximum containment requirement and high costs associated with conducting studies with highly pathogenic arenaviruses, the aim of the present work was to evaluate favipiravir in the guinea pig PICV infection model [32], [33], as a means to optimize treatment conditions to assist in the planning of future studies in biosafety level 4 (BSL-4) containment.…”
Section: Introductionmentioning
confidence: 99%