The Guardian of Vision: Intelligent Bacteriophage‐Based Eyedrops for Clinical Multidrug‐Resistant Ocular Surface Infections
Luojia Chen,
Ming‐Yu Wu,
Si‐Ling Chen
et al.
Abstract:Clinical multidrug‐resistant Pseudomonas aeruginosa (MDR‐PA) is the leading cause of refractory bacterial keratitis (BK). However, the reported BK treatment methods lack biosecurity and bioavailability, which usually causes irreversible visual impairment and even blindness. Herein, for BK caused by clinically isolated MDR‐PA infection, armed phages are modularized with the type I photosensitizer (PS) ACR‐DMT, and an intelligent phage eyedrop is developed for combined phagotherapy and photodynamic therapy (PDT)… Show more
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