The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth

Chang, Leo; Kreko‐Pierce, Tabita; Eaton, Benjamin A.

doi:10.1242/bio.011262

Cited by 4 publications

(6 citation statements)

References 31 publications

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“…As mentioned above, Arl1 also plays a role in Drosophila (Chang et al, 2015;Eisman et al, 2006;Lee et al, 2011;Torres et al, 2014) and in parasites (Price et al, 2005). In Drosophila, arf72A, the fly ortholog of mammalian Arl1, was shown to be required for Drosophila development and the centrosome cycle (Eisman et al, 2006).…”

Section: Drosophila and Parasitesmentioning

confidence: 90%

“…Genetic alterations of Arl1 as well as its effectors were used to characterize developmental and physiological phenotypes (summarized in Fig. 1) (Chang et al, 2015;Cruz-Garcia et al, 2013;Eiseler et al, 2016;Gehart et al, 2012;Hesse et al, 2013;Hsu et al, 2016;Labbaoui et al, 2017;Lieu et al, 2008;Liu et al, 2006;Lock et al, 2005;Marešová and Sychrová, 2010;Marešová et al, 2012;Murray and Stow, 2014;Price et al, 2005;Torres et al, 2014;Yang and Rosenwald, 2016). In mammalian cells, these functions affect a wide range of fundamental cellular processes, including cell polarity (Lock et al, 2005), innate immunity (Bremond et al, 2009;Lieu et al, 2008;Murray and Stow, 2014;Stanley et al, 2012), lipid droplet and chylomicron formation (Hesse et al, 2013;Jaschke et al, 2012), as well as the secretion of insulin (Gehart et al, 2012), chromogranin A (CruzGarcia et al, 2013) and matrix metalloproteinases (MMPs) (Eiseler et al, 2016).…”

Section: The Physiological Roles Of Arl1mentioning

confidence: 99%

“…In yeast, Arl1 and its effectors are also involved in numerous functions, such as maintenance of cell wall integrity (Liu et al, 2006), ion homeostasis (Marešová and Sychrová, 2010;Munson et al, 2004;Rosenwald et al, 2002), tolerance to stress factors (Jaime et al, 2012;Marešova et al, 2012;Yang and Rosenwald, 2016), regulation of cell proliferation (Benjamin et al, 2011), the unfolded protein response (UPR) (Hsu et al, 2016) and also in the ability of yeast to cause disease (Labbaoui et al, 2017). In addition, these factors regulate the quality control of the endoplasmic reticulum (ER) (Lee et al, 2011), tissue development (Eisman et al, 2006;Torres et al, 2014) and neuronal growth in Drosophila (Chang et al, 2015), and control cell viability in parasites (Price et al, 2005). Altogether, the data from these functional studies indicate that Arl1 controls the trafficking of numerous cargos at the TGN in a variety of organisms.…”

Section: The Physiological Roles Of Arl1mentioning

confidence: 99%

“…Interestingly, loss of Arl1 induces cell death in imaginal discs and reduces the size of secretory granules in the larval salivary gland, supporting the notion that Arl1 is involved in normal wing development and salivary granule formation . Recently, Arl1, Arfaptin and the Arf-GEF Gartenzwerg (the Drosophila ortholog of the Arf-GEF GBF1) were found to colocalize at the Golgi in Drosophila motor neurons and to function in a newly described signaling pathway during synapse growth (Chang et al, 2015).…”

Section: Drosophila and Parasitesmentioning

confidence: 99%

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Multiple activities of Arl1 GTPase in the trans-Golgi network

Lee

2017

Journal of Cell Science

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ADP-ribosylation factors (Arfs) and ADP-ribosylation factor-like proteins (Arls) are highly conserved small GTPases that function as main regulators of vesicular trafficking and cytoskeletal reorganization. Arl1, the first identified member of the large Arl family, is an important regulator of Golgi complex structure and function in organisms ranging from yeast to mammals. Together with its effectors, Arl1 has been shown to be involved in several cellular processes, including endosomal trans-Golgi network and secretory trafficking, lipid droplet and salivary granule formation, innate immunity and neuronal development, stress tolerance, as well as the response of the unfolded protein. In this Commentary, we provide a comprehensive summary of the Arl1-dependent cellular functions and a detailed characterization of several Arl1 effectors. We propose that involvement of Arl1 in these diverse cellular functions reflects the fact that Arl1 is activated at several late-Golgi sites, corresponding to specific molecular complexes that respond to and integrate multiple signals. We also provide insight into how the GTP-GDP cycle of Arl1 is regulated, and highlight a newly discovered mechanism that controls the sophisticated regulation of Arl1 activity at the Golgi complex.

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Section: Drosophila and Parasitesmentioning

confidence: 90%

Section: The Physiological Roles Of Arl1mentioning

confidence: 99%

Section: The Physiological Roles Of Arl1mentioning

confidence: 99%

Section: Drosophila and Parasitesmentioning

confidence: 99%

See 2 more Smart Citations

Multiple activities of Arl1 GTPase in the trans-Golgi network

Lee

2017

Journal of Cell Science

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“…Both the Drosophila NMJ model and mammalian models were used to show how distinct human neurological diseases are caused by different point mutations in Glued, by primarily affecting transport initiation (Perry Syndrome, a Parkinson's like disorder) versus long‐range transport (HMN7B, a motor neuron disease). Further, the Golgi protein Arfip/Arfaptin, which genetically and physically interacts with the dynactin complex and contributes to synaptic growth at the Drosophila NMJ, is not required for long‐range axonal transport, and may instead function in Golgi‐dependent delivery of components required for synapse growth . Thus, although the initiation of transport and subsequent long‐range movements are intertwined via dynactin , they can be mechanistically separated via dynactin‐associated factors.…”

Section: Regulation Of Bmp Signaling By Membrane Trafficmentioning

confidence: 99%

The Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from Drosophila

Deshpande

Rodal

2015

Traffic

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Neurons require target-derived autocrine and paracrine growth factors to maintain proper identity, innervation, homeostasis and survival. Neuronal growth factor signaling is highly dependent on membrane traffic, Neurons are highly specialized cells that depend heavily on membrane traffic for multiple facets of their unique physiology: to facilitate the rapid release and recycling of neurotransmitter-containing synaptic vesicles, to maintain their extreme and polarized morphology and compartmentalization and to sustain and regulate intracellular transport and signaling over extremely long distances. In particular, endocytic traffic is required to control the localization and activity of the signaling proteins and transmembrane receptors that govern neuronal growth and survival. To maintain appropriate innervation and activity, neurons respond to target-derived paracrine and autocrine growth factors. These growth factors bind to receptors that are internalized and trafficked along the endocytic and endosomal pathways, exerting local effects at synapses as well as long-range and long-lasting effects at neuronal cell bodies (1). The Drosophila larval neuromuscular junction (NMJ) is an excellent model for studying the cell biology of growth factor receptor signaling in neurons as it is exquisitely accessible for genetic manipulation, electrophysiology and functional analyses (2). Of particular importance, this system offers unparalleled advantages for imaging neurons in their normal developmental context, as both motor axons and NMJs are found at the surface of filleted larvae for high-resolution microscopy, and are also visible through the larval cuticle in intact, anesthetized animals (3). Over the course of larval development, the muscle area grows 100-fold, requiring synaptic activity-dependent expansion of synaptic arbors via the addition of new synaptic varicosities or boutons (4, 5; Figure 1A). This expansion requires a number of growth signaling pathways at the NMJ, including (but not limited to) www.traffic.dk 87

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Key roles of Arf small G proteins and biosynthetic trafficking for animal development

Rodrigues

Harris

2017

Small GTPases

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Although biosynthetic trafficking can function constitutively, it also functions specifically for certain developmental processes. These processes require either a large increase to biosynthesis or the biosynthesis and targeted trafficking of specific players. We review the conserved molecular mechanisms that direct biosynthetic trafficking, and discuss how their genetic disruption affects animal development. Specifically, we consider Arf small G proteins, such as Arf1 and Sar1, and their coat effectors, COPI and COPII, and how these proteins promote biosynthetic trafficking for cleavage of the Drosophila embryo, the growth of neuronal dendrites and synapses, extracellular matrix secretion for bone development, lumen development in epithelial tubes, notochord and neural tube development, and ciliogenesis. Specific need for the biosynthetic trafficking system is also evident from conserved CrebA/Creb3-like transcription factors increasing the expression of secretory machinery during several of these developmental processes. Moreover, dysfunctional trafficking leads to a range of developmental syndromes.

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The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth

Cited by 4 publications

References 31 publications

Multiple activities of Arl1 GTPase in the trans-Golgi network

Multiple activities of Arl1 GTPase in the trans-Golgi network

The Crossroads of Synaptic Growth Signaling, Membrane Traffic and Neurological Disease: Insights from Drosophila

Key roles of Arf small G proteins and biosynthetic trafficking for animal development

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