The Growth of Glioblastoma Multiforme (Astrocytomas, Grades 3 and 4) in Neurosurgical Practice

Virtual brain tumours (gliomas) enhance the reality of medical imaging and highlight inadequacies of current therapy

“…Resection and other localized treatment methods Matsukado et al (1961) analyzed 100 autopsy specimens of supratentorial glioblastomas searching for clues that might favour successful resection. They reported that 53 cases appeared grossly and microscopically confined to one cerebral hemisphere, 36 of these limited to the cerebral cortex and white matter and 17 invading the basal ganglia, internal capsule or diencephalon.…”

“…Considered in the present light, however, the patterns of their lobar and multilobar cases suggest that the major significant difference is the diffusion coefficient: low in those that remain relatively localized to the cortex and white matter (36 cases), higher in those that invade deep cerebral nuclei unilaterally (17 cases), still higher in those that cross the midline through the corpus callosum (10 cases) and highest in those that invade into the contralateral deep cerebral nuclei (15 cases). Matsukado et al (1961) estimated that the 36 relatively localized cases could have been cured by radical surgery but Jelsma and Bucy (1967) failed to cure any even with extensive resection approaching hemispherectomy. This fits with our conclusion that submicroscopic invasion had taken place.…”

Up and Down Estimate of Therapy Quality in Non-Linear Distributed Mathematical Glioma Model

“…Глиомы чрезвычайно инвазивны, то есть проникают в окружающие ткани так, что часто бывает невозможно провести четкую границу между областью поражения раком и областью, пока не потревоженной. Регенерация на краю области резекции всегда в конечном итоге приводит к летальному исходу [4]. Эксперименты показывают [2], что через 7 дней после имплантации опухоли в мозг крысы клетки глиомы можно было обнаружить по всей нервной системе.…”

Novel Treatment Strategies for Malignant Gliomas Using Neural Stem Cells

“…Although a large conglomeration of tumor cells may be found by radiographic imaging in one location, small numbers of tumor cells can form microsatellites that may be located far away from the main tumor, sometimes even in the contralateral hemisphere. 8,41,42 The presence of these microsatellite tumors makes complete surgical resection very difficult and is thought to contribute to high recurrence of glioblastomas.…”