The growth of biomedical terahertz research

Fan, Shuting; He, Yu; Ung, Benjamin S.-Y.; Pickwell‐MacPherson, Emma

doi:10.1088/0022-3727/47/37/374009

Cited by 137 publications

(80 citation statements)

References 65 publications

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“…THz light is also able to probe the molecular structure of chemicals and resolve thin layers of materials e.g., pharmaceutical tablet coatings and the stratum corneum of the skin (in certain locations). In this review, we update our previous overviews from 2012 (1) and 2014 (2), and summarise recent findings relevant to advancing the usage of THz imaging for medical applications. In Section 2 we summarise advances in THz biomedical understanding, including work on both the origin of contrast and in tissue modelling.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

Self Cite

219

113

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Terahertz instrumentation has improved significantly in recent years such that THz imaging systems have become more affordable and easier to use. THz systems can now be operated by non-THz experts greatly facilitating research into many potential applications. Due to the non-ionising nature of THz light and its high sensitivity to soft tissues, there is an increasing interest in biomedical applications including both in vivo and ex vivo studies. Additionally, research continues into understanding the origin of contrast and how to interpret terahertz biomedical images. This short review highlights some of the recent work in these areas and suggests some future research directions.

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Section: Introductionmentioning

confidence: 99%

Recent advances in terahertz technology for biomedical applications

Sun¹,

He²,

Li³

et al. 2017

Quant. Imaging Med. Surg.

Self Cite

219

113

View full text Add to dashboard Cite

show abstract

“…One focus where THz has shown particular promise is in biomedical and pharmaceutical research, where the work in THz applications has grown rapidly, especially in the field of biomedical imaging [5]. This is in large part due to THz frequencies showing significant distinctions between many different kinds of diseased and healthy tissue [6,7].…”

Section: Introductionmentioning

confidence: 99%

Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Bowman

El-Shenawee

Campbell

2016

Biomed. Opt. Express

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This work presents experimental and analytical comparison of terahertz transmission and reflection imaging modes for assessing breast carcinoma in excised paraffinembedded human breast tissue. Modeling for both transmission and reflection imaging is developed. The refractive index and absorption coefficient of the tissue samples are obtained. The reflection measurements taken at the system's fixed oblique angle of 30° are shown to be a hybridization of TE and TM modes. The models are validated with transmission spectroscopy at fixed points on fresh bovine muscle and fat tissues. Images based on the calculated absorption coefficient and index of refraction of bovine tissue are successfully compared with the terahertz magnitude and phase measured in the reflection mode. The validated techniques are extended to 20 and 30 μm slices of fixed human lobular carcinoma and infiltrating ductal carcinoma mounted on polystyrene microscope slides in order to investigate the terahertz differentiation of the carcinoma with non-cancerous tissue. Both transmission and reflection imaging show clear differentiation in carcinoma versus healthy tissue. However, when using the reflection mode, in the calculation of the thin tissue properties, the absorption is shown to be sensitive to small phase variations that arise due to deviations in slide and tissue thickness and non-ideal tissue adhesion. On the other hand, the results show that the transmission mode is much less sensitive to these phase variations. The results also demonstrate that reflection imaging provides higher resolution and more clear margins between cancerous and fibroglandular regions, cancerous and fatty regions, and fibroglandular and fatty tissue regions. In addition, more features consistent with high power pathology images are exhibited in the reflection mode images.

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“…Interest in biomedical THz research is growing rapidly [56,57]. THz radiation has very low photon energy and thus does not cause any ionization hazard for biological tissues.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Terahertz Pulse Detection Techniques and Imaging Applications

Chen¹,

Guo²

2017

Terahertz Spectroscopy - A Cutting Edge Technology

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Recent years have witnessed successful developments of detection techniques of teraherz (THz) pulse radiation and its imaging applications such as security, medicine and environmental sensing, to name an important few. Progress of detection techniques has been made in many aspects, including detection sensitivity, real-time detection, roomtemperature operation, detection bandwidth and dynamic range, spatial (wavefront) and temporal proiles and so on. New detection techniques utilizing cuting-edge materials, sensors, systems and even novel detection mechanisms contribute to advances in teraherz pulse detection. While detection techniques continuously improve, teraherz pulsed imaging (TPI) also inds broad and intriguing applications. For instance, TPI has shown applications in nondestructive evaluation in pharmaceutics, biomedical characterization of tissues, medical diagnosis of cancers, identiication of explosive hazards and examination of art and archeology. The chapter highlights recent progress of teraherz pulse detection techniques and imaging applications.

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The growth of biomedical terahertz research

Cited by 137 publications

References 65 publications

Recent advances in terahertz technology for biomedical applications

Recent advances in terahertz technology for biomedical applications

Terahertz transmission vs reflection imaging and model-based characterization for excised breast carcinomas

Terahertz Pulse Detection Techniques and Imaging Applications

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