1968
DOI: 10.1017/s0022172400040997
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The growth of a virulent strain of African swine fever virus in domestic pigs

Abstract: SUMMARYPigs were infected by the intranasal instillation of a large dose (ca. 107·0 ID 50) of a highly virulent strain of African swine fever virus (ASFV) and the progress of the infection was studied by the ‘routine titration approach’ (Mims, 1964) using pig bone marrow cultures.Virus growth was established within 16–24 hr. in the retropharyngeal but not in the alimentary or nasal mucosae or the tonsils. By 24–40 hr. the virus was consistently present in the retropharyngeal lymph nodes, almost invariably the … Show more

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Cited by 51 publications
(27 citation statements)
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“…Failure of the virus to spread to susceptible pigs in close contact with infected animals during their first 12-24 hr. of pyrexia must, therefore, be due to inadequate degrees of contamination of the environment, including food and water, rather than the absence of virus excretion, as suggested by Plowright et al (1968). The dose of ASFV necessary to infect pigs by natural routes has not been determined accurately, but Heuschele (1967) quoted Maurer et at.…”
Section: Discussionmentioning
confidence: 99%
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“…Failure of the virus to spread to susceptible pigs in close contact with infected animals during their first 12-24 hr. of pyrexia must, therefore, be due to inadequate degrees of contamination of the environment, including food and water, rather than the absence of virus excretion, as suggested by Plowright et al (1968). The dose of ASFV necessary to infect pigs by natural routes has not been determined accurately, but Heuschele (1967) quoted Maurer et at.…”
Section: Discussionmentioning
confidence: 99%
“…Virus strains (a) The Tengani strain caused an epizootic of ASF in Malawi in 1962 (Cox & Hess, 1962) and was known to cause a rapid lethal disease in domestic swine, the mean death-time being 2-9 days (Plowright et al 1968). The virus was stored at -700 C. in the form of a 10 % (w/v) spleen suspension which, when titrated in pig bone marrow (PBM) cultures, had a titre of 107 HAD 50/ml.…”
Section: Methodsmentioning
confidence: 99%
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