Background
Prescription opioid use and overdose deaths are increasing in the U.S. Among under-age-65, disabled Medicare beneficiaries, the rise in musculoskeletal conditions as qualifying diagnoses suggests opioid analgesic use may be common and increasing, raising safety concerns.
Methods
From a 40% random-sample Medicare denominator, we identified fee-for-service beneficiaries under-age-65 and created annual enrollment cohorts 2007-2011 (6.4 million person-years). We obtained adjusted, annual opioid use measures: any use, chronic use (≥6 prescriptions), intensity of use (daily morphine equivalent dose (MED)), opioid prescribers per user. Geographic variation was studied across Hospital Referral Regions (HRRs).
Results
Most measures peaked in 2010. The adjusted proportion with any opioid use was 43.9% in 2007, 44.7% in 2010 and 43.7% in 2011. The proportion with chronic use rose from 21.4% in 2007 to 23.1%, in 2011. Among chronic users: mean MED peaked at 81.3 mg in 2010, declining to 77.4 mg in 2011; in 2011, 19.8% received ≥ 100 mg MED; 10.4% received ≥200 mg. In 2011 HRR-level measures varied broadly (5th to 95th percentile): any use: 33.0% to 58.6%, chronic use: 14.0% to 36.6%; among chronic users, mean MED ranged from 45 mg to 125 mg; mean annual opioid prescribers from 2.4 to 3.7.
Conclusions
Among these beneficiaries, opioid use was common. While intensity stabilized, the population using opioids chronically grew. Variation shows a lack of standardized approach and reveals regions with mean MED at levels associated with overdose risk. Future work should assess outcomes, chronic use predictors and policies balancing pain control and safety.