The group of schizoaffective and related psychoses: A follow-up study

Welner, Amos; Croughan, Jack; Fishman, Roberta; Robins, Eli

doi:10.1016/0010-440x(77)90039-6

Cited by 60 publications

(23 citation statements)

References 14 publications

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“…In a review of these, noted that the outcome has been found to be intermediate between schizophrenia and manic-depressive psychosis (Jager et al, 2004, Tsuang andDempsey, 1979) similar to schizophrenia (Himmelhoch et al, 1981, Tsuang and Coryell, 1993, Welner et al, 1977, similar to manic-depressive psychosis (Marneros et al, 1990, or heterogeneous (Berg et al, 1983, Brockington et al, 1980a, Brockington et al, 1980b. One study stands out from the others because of its use of rigorous RDC for schizoaffective disorder and also because of the length and detailed nature of the follow-up.…”

Section: Clinical Studies Of Schizoaffective Disordermentioning

confidence: 99%

“…The categorical model proposes that schizophrenia and affective disorders are distinct and mutually exclusive illnesses and views schizoaffective disorder as either a form of schizophrenia (Lehman, 1975, Welner et al, 1977, a form of affective disorder , or an illness distinct from both schizophrenic and affective disorders, as argued by . On the other hand, the continuum or spectrum model defines a continuum of psychosis severity and considers schizophrenia and affective disorders as opposite poles, with schizoaffective disorder midway between the two poles.…”

Section: Introduction Nosologymentioning

confidence: 99%

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Neuropsychological and Brain Functional Changes Across the Different Phases of Schizoaffective Disorder

Merce

Raduà

Amann

2015

European Psychiatry

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Schizoaffective disorder was first described by J. Kasanin in 1933, since then its nosology remains a matter of controversy. We aim to add further neurobiological findings to this debate.Memory and executive function were tested in 22 acutely ill schizoaffective patients; they also underwent fMRI scanning during performance of the n-back working memory test. The same measures were obtained after they had been in remission for ≥2 months. 22 matched healthy individuals were also examined.Compared to controls, acute schizoaffective patients showed reduced activation in the DLPFC and also a failure of deactivation in the medial frontal cortex (1).In clinical remission, schizomanic patients showed an improvement of memory but not of executive function, while schizodepressive patients did not change in either domain. All schizoaffective patients in clinical remission showed memory and executive impairment compared to the controls. On fMRI, acutely ill schizomanic patients had reversible frontal hypo-activation when compared to clinical remission, while activation patterns in ill and remitted schizodepressive patients were similar. The whole group of schizoaffective patients in clinical remission showed a failure of de-activation in the medial frontal gyrus compared to the healthy controls. There was evidence for memory improvement and state dependent changes in activation in schizomanic patients across relapse and remission (2).The results demonstrate that schizoaffective disorder is characterized by medial frontal failure of deactivation and hence default mode network dysfunction (3), which is present during both active illness and remission suggesting that it is a trait factor for the disorder.

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Section: Clinical Studies Of Schizoaffective Disordermentioning

confidence: 99%

Section: Introduction Nosologymentioning

confidence: 99%

Neuropsychological and Brain Functional Changes Across the Different Phases of Schizoaffective Disorder

Merce

Raduà

Amann

2015

European Psychiatry

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“…The results of Perris (1974) have shed some doubt on these findings but liis cases were strictly confined to 'cyclic' disorders. If it is accepted that the course in the latter group is marked by entirely clear periods of remission, there is a distinction from schizoaffective psychosis in which as the findings of Weiner et al (1977) have shown, the results are indeterminate and a chronic course towards deterioration occurs in the majority of cases.…”

Section: Schizoaffective Psychosismentioning

confidence: 99%

“…Some studies (Astrup and Noreik, 1966;Vaillant, 1964) have reported a benign course and outcome for such syndromes. But others including the recent investigation by Weiner et al (1977) of 114 patients have found affective symptoms to be without predic tive value. As its course proved, in the main, chronic and unfavourable, the authors concluded that schizo-affective psychosis resembles schizophrenia rather than affective disorder.…”

Section: Prognosismentioning

confidence: 99%

The Relationship of ‘Nuclear’ and ‘Atypical’ Psychoses:

Roth¹,

McClelland²

1979

Psychopathology

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The paper sets out the arguments in favour of utilising both a ‘strict’ definition corresponding to the ‘nuclear’ concept of schizophrenia and a ‘broader’ definition that also subsumes ‘atypical’ schizophreniform and related syndromes. Evidence is adduced rejecting the view that attempts to effect a complete separation between ‘nuclear’ and other forms of schizophrenic disorders based on phenomenological, hereditary, prognostic, etiological and other lines. Both the unity and the diversity of the schizophrenic family of disorders must be given explicit recognition in clinical and scientific work. The value of the ‘nuclear’ concept has been demonstrated by the IPSS study among other enquiries. The advantages of the broad definition are twofold. It makes for a flexibility and openness of approach in diagnosis and treatment of schizophrenia that are indispensable at the present time. The value of the ‘broad’ definition is that it encompasses a range of phenomena that have been shown to be related to one another. They may therefore be compared and contrasted. It is argued that new knowledge about the etiology of schizophrenia may be acquired in this manner. Tentative definitions for the ‘nuclear’ and ‘broad’ groups of disorder are given.

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“…28] schizophreniform psychosis [Langfeldt, 1939[Langfeldt, , 1969 too broad concept; too little positive criteriapredicitive validation : Langfeldt [1956], Holmboe and Astrup [1957], Weiner and Strömgren [1958] remitting schizophrenia [Bleuler, 1972: [Kretschmer, 1953;Pauleikhojf, 1957] 'mixture-model' refused : Bleuler [1911] accepted : Bleuler and Bleuler [1955], Gaupp [1926], Mayer-Gross [1932] 'legierung' (compound) psychoses [Arnold ct al.. 1965] empirical decomposition into affective and schizophrenic variants [Tsuang, 1979] schizomania [Laforgue, 1926;Claude et al, 1934] becoming an affective variant [Fowler, 1978] schizoaffective psychosis [Kasanin. 1933] becoming a schizophrenic variant [ Weiner et al, 1977 'feverish delirium' in the case of physical accompanying the 'idiopathic amentia'. This use of terminology is also adopted by more recent authors, such as Pauleikhoff [1969], who regards 'amentia' as one of the types of the 'atypical psychoses' and the characteristic syndrome of 'amentia' as theotherwise very disputed -puerperal psychosis.…”

Section: Systems Of Referencementioning

confidence: 99%

Concepts of Schizo-Affective Psychoses

Pethö¹

1983

Psychopathology

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After offering a brief survey of some major unresolved contradictions in the field of clinical psychiatry, the author looks over the historical development of syndromatological entities related to the so-called schizo-affective psychoses. These syndromes were described with reference to somatogenic, endogenous, and psychogenic psychoses and as (relatively) distinct entities, respectively. For grasping these syndromes as independent entities it seems to be necessary to take into account a few holistic characteristics and to put aside the ‘mixture model’ while making research diagnostic criteria.

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The group of schizoaffective and related psychoses: A follow-up study

Cited by 60 publications

References 14 publications

Neuropsychological and Brain Functional Changes Across the Different Phases of Schizoaffective Disorder

Neuropsychological and Brain Functional Changes Across the Different Phases of Schizoaffective Disorder

The Relationship of ‘Nuclear’ and ‘Atypical’ Psychoses:

Concepts of Schizo-Affective Psychoses

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