The Group A Streptococcal Carrier State

Gerber, Michael A.; Randolph, Martin F.; Mayo, Donald R.

doi:10.1001/archpedi.1988.02150050100043

Cited by 43 publications

(18 citation statements)

References 16 publications

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“…GAS carriage was defined as the presence of GAS in the upper respiratory tract without an antibody response. 15 GAS typing, which is mainly based on the M protein, includes serotyping (Lancefield serologic typing) and emm sequence typing (genotyping of the aminoterminal portion of the M protein gene).…”

Section: Definitionsmentioning

confidence: 99%

Burden of Acute Sore Throat and Group A Streptococcal Pharyngitis in School-aged Children and Their Families in Australia

et al. 2007

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Section: Definitionsmentioning

confidence: 99%

Burden of Acute Sore Throat and Group A Streptococcal Pharyngitis in School-aged Children and Their Families in Australia

et al. 2007

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“…However, not all patients with a positive microbiological test for GABHS and symptoms from the throat have a GABHS-caused tonsillopharyngitis. Some of these patients may have a virus infection and are only carriers of GABHS (1,(3)(4)(5). and may not benefit from treatment with antibiotics at that time (4,6).…”

mentioning

confidence: 99%

The prevalence of beta-haemolytic streptococci in throat specimens from healthy children and adults: Implications for the clinical value of throat cultures

Gunnarsson

Holm

Söderström

1997

Scandinavian Journal of Primary Health Care

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“…In the Eighties, 5 clinical trials were done in children. The study of Gerber et al [12] was not compliance controlled; Nelson's work [13] was not double blind; and the study by Krober [14] has occasioned considerable comment because of its very small size (26 GABHS-positives). Only the studies of Randolph et al (1985) and Pichichero et al (1987) fulfill most of the important methodological criteria.…”

Section: Discussionmentioning

confidence: 99%

Effect of Penicillin on the clinical course of streptococcal pharyngitis in general practice

Meyere¹,

Mervielde

Verschraegen

et al. 1992

Eur J Clin Pharmacol

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The aim of the study was to explore whether penicillin was superior to placebo in altering the clinical course of proven streptococcal pharyngitis. A randomised, parallel, double blind placebo controlled trial of 10 days duration was undertaken in 42 general practices in the Gent region (Flemish part of Belgium). Phenoxymethylpenicillin (adults 250 mg t.i.d. and children 125 mg t.i.d.) or placebo were administrated to 173 patients, aged 5 to 50 y, with acute sore throat and a positive culture for Group A beta-haemolytic streptococci. Penicillin and placebo tablets were identical. Patient compliance was monitored by assay of penicillin in urine (Sarcina lutea method). The primary outcome variable was sore throat as recorded by the physician on Day 3. The experiences of the patients themselves over the 10 day period were also assessed. Secondary outcome variables were other local and general symptoms and signs of streptococcal throat infection. In the penicillin group on Day 3, 23.2% of the patients still complained of sore throat versus 65.9% in the placebo group: difference 42.7% (C.I. 29.4%, 56.1%). This finding was confirmed by survival analysis of the symptom 'sore throat', as recorded by the patients. The physicians recorded on Day 3 a significant positive effect on another symptom (malaise: P < 0.04) and certain clinical signs (abnormal throat: P < 0.07; and redness of throat: P < 0.003). Penicillin had more adverse effects than placebo (P < 0.007). It also inhibited the rise in ASLO (P < 0.001). In this study in general practice, penicillin had a slight but definitive positive effect on the clinical evolution of streptococcal pharyngitis.(ABSTRACT TRUNCATED AT 250 WORDS)

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The Group A Streptococcal Carrier State

Cited by 43 publications

References 16 publications

Burden of Acute Sore Throat and Group A Streptococcal Pharyngitis in School-aged Children and Their Families in Australia

Burden of Acute Sore Throat and Group A Streptococcal Pharyngitis in School-aged Children and Their Families in Australia

The prevalence of beta-haemolytic streptococci in throat specimens from healthy children and adults: Implications for the clinical value of throat cultures

Effect of Penicillin on the clinical course of streptococcal pharyngitis in general practice

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