The Grinspan Syndrome: “Fact” or “fiction” – A Meta Analysis research

Garlapati, Komali; Naik, Vathsala; Sharma, Gaurav

doi:10.1016/j.jpfa.2017.03.002

Cited by 1 publication

(4 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The patient had a history of high blood pressure, and although he did not realize it, the laboratory findings showed an elevated HbA1c, SGOT, and SGPT concentration (presumably caused by the routine captopril intake, and long-term herbal drinks consumption). A diabetic patient with a history of hypertension can develop OLP, also called Grinspan’s syndrome [ 5 , 11 ]. Nevertheless, the association between the 3 entities is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Nevertheless, the association between the 3 entities is unclear. A meta-analysis study by Garlapati, Naik, and Sharma in 2017 found there was no association between OLP, diabetes mellitus, and vascular hypertension [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…LP is a chronic mucocutaneous inflammatory disease that involves the skin, oral and genital mucosa, hair follicles of the scalp, and fingernails [ 3 ]. Oral lichen planus (OLP) is a lichen planus involving the oral mucosa and is associated with the T-cell activity that mediates an autoimmune condition [ 4 , 5 ]. OLP can co-occur with LP or can precede LP.…”

Section: Introductionmentioning

confidence: 99%

“…OLP can co-occur with LP or can precede LP. Around 1–2% of the world population has OLP [ 5 ]. It mostly occurs in females (approximately 77%) aged 30–80 years old, with no race differences [ 2 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Efficacy of Systemic Acyclovir as Adjuvant Therapy for Oral Lichen Planus

2021

View full text Add to dashboard Cite

Patient: Male, 73-year-old Final Diagnosis: Oral lichen planus (OLP) Symptoms: Painful tongue • taste impairment Medication: Acyclovir • antiseptic • corticosteroids • folic acid • vitamin B12 Clinical Procedure: DASS test • medications • OHIP test • serological examinations Specialty: Dentistry • General and Internal Medicine • Pathology Objective: Unusual setting of medical care Background: Oral lichen planus (OLP) is a chronic inflammatory disease involving the oral mucosa, associated with the T-cell activity that mediates an autoimmune condition, with various predisposing factors, such as herpes simplex virus (HSV). The first-line treatment is topical corticosteroids. However, additional therapy can be given according to the underlying factors. This report assessed the efficacy of oral acyclovir as adjuvant therapy in the management of OLP. Case Report: A 73-year-old man came to our unit reporting he had recurring sores on the tongue for the past 10 years. The tongue was painful and there was taste impairment. Intraoral examination showed erosion and erythematous areas surrounded by white net-like plaques on the tongue and buccal mucosa, as well as depapillation on 2/3 dorsal anterior of the tongue. The diagnosis of reticular and erosive OLP was determined based on clinical features. The patient was prescribed topical corticosteroids, multivitamins, and mouthwash containing chlorine dioxide. Supporting examinations were performed to rule out systemic predisposing factors. The patient was referred for anti-HSV-1 IgG testing, and it was reactive (34.8 U/mL). Thus, oral acyclovir was prescribed. After 2 weeks of antiviral treatment, the tongue pain and altered taste were resolved, and the clinical features showed significant improvement. Conclusions: Management of OLP requires a comprehensive approach. OLP symptoms can be relieved if treatment is not only limited to reducing the inflammation but also seeks to remedy other comorbidities, in this case, administration of an antiviral agent to resolve the HSV-1 involvement.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations