The grey mouse lemur: A non-human primate model for ageing studies

Languille, Solène; Blanc, Stéphane; Blin, Olivier; Canale, Cindy I.; Dal-Pan, Alexandre; Devau, Gina; Dhénain, Marc; Dorieux, Olène; Epelbaum, Jacques; Gomez, Doris; Hardy, Isabelle; Henry, Pierre‐Yves; Irving, Enid; Marchal, Julia; Mestre‐Francés, Nadine; Perret, Martine; Picq, Jean‐Luc; Pifferi, Fabien; Rahman, Ashikur; Schenker, Esther; Terrien, Jérémy; Théry, Marc; Verdier, Jean‐Michel; Aujard, Fabienne

doi:10.1016/j.arr.2011.07.001

Cited by 147 publications

(183 citation statements)

References 129 publications

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“…Longevity is slightly male-biased in our captive study population [19,45] but strongly female-biased in the wild [30]. Roaming by males during the mating season [41] coincides with increased male mortality and, along with an age-associated increase in risk taking by males [46], probably drives the overall sex bias in longevity in the wild [30].…”

Section: Introductionmentioning

confidence: 97%

“…The grey mouse lemur is a small, sexually monomorphic primate that is emerging as a model species for ageing [19]. For individuals that survive to adulthood (here, to age 12 months or more), the average lifespan in captivity is approximately 5 years [19,45] (maximum in our captive colony was 13.8 years) but only 2 -3 years in the wild (lifespan of at least 10 years recorded in our study population).…”

Section: Materials and Methods (A) Study Speciesmentioning

confidence: 99%

“…For individuals that survive to adulthood (here, to age 12 months or more), the average lifespan in captivity is approximately 5 years [19,45] (maximum in our captive colony was 13.8 years) but only 2 -3 years in the wild (lifespan of at least 10 years recorded in our study population). The annual turnover rate in nature is approximately 50% owing to high levels of EM [30] (mainly reptilian, avian and mammalian predation [47]).…”

Section: Materials and Methods (A) Study Speciesmentioning

confidence: 99%

“…Under natural conditions, individuals in sufficient body condition use torpor to conserve energy during the dry season [49], whereas no spontaneous use of torpor is seen under usual captive conditions [50]. Data from captivity suggest the onset of FS at around age 5 years in males [19,33,45,48].…”

Section: Materials and Methods (A) Study Speciesmentioning

confidence: 99%

“…In spite of the supposed significance of extrinsic factors in shaping life histories, ageing research is still largely biased towards captive animals living under standard, benign conditions (e.g. [16,19,20]). In the wild, studies of FS have largely focused on long-lived, large-bodied animals that face relatively low levels of environmental hazard (ungulates [10,21], sea-birds [22], seals [23] and primates [6,24]).…”

Section: Introductionmentioning

confidence: 99%

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Senescence or selective disappearance? Age trajectories of body mass in wild and captive populations of a small-bodied primate

et al. 2014

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Classic theories of ageing consider extrinsic mortality (EM) a major factor in shaping longevity and ageing, yet most studies of functional ageing focus on species with low EM. This bias may cause overestimation of the influence of senescent declines in performance over condition-dependent mortality on demographic processes across taxa. To simultaneously investigate the roles of functional senescence (FS) and intrinsic, extrinsic and condition-dependent mortality in a species with a high predation risk in nature, we compared age trajectories of body mass (BM) in wild and captive grey mouse lemurs (Microcebus murinus) using longitudinal data (853 individuals followed through adulthood). We found evidence of non-random mortality in both settings. In captivity, the oldest animals showed senescence in their ability to regain lost BM, whereas no evidence of FS was found in the wild. Overall, captive animals lived longer, but a reversed sex bias in lifespan was observed between wild and captive populations. We suggest that even moderately condition-dependent EM may lead to negligible FS in the wild. While high EM may act to reduce the average lifespan, this evolutionary process may be counteracted by the increased fitness of the long-lived, high-quality individuals.

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Section: Introductionmentioning

confidence: 97%

Section: Materials and Methods (A) Study Speciesmentioning

confidence: 99%

Section: Materials and Methods (A) Study Speciesmentioning

confidence: 99%

Section: Materials and Methods (A) Study Speciesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Senescence or selective disappearance? Age trajectories of body mass in wild and captive populations of a small-bodied primate

et al. 2014

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Genomes

Knapp

2018

The International Encyclopedia of Biological Anthropology

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A genome represents all the genetic information required for an organism to grow, function, and reproduce. For vertebrates, genetic information is passed from parent to offspring. The nuclear genome, the largest part of the human genome, is produced when both parents contribute half of their genetic information to offspring. The mitochondrial genome, which is significantly smaller than the nuclear genome, is contributed solely along the maternal line. Based on extensive studies of both genomes over many decades, scientists know how genetic information is transmitted on chromosomes, where many genes are located on chromosomes, and how some DNA sequences relate to genes. Intensive study of the human genome began in the 1990s and work is ongoing in an effort to gain further knowledge about the human genome, its variability, and what evolutionary forces have contributed to the modern human genome.

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Lemurs

Clark¹

2020

Exotic Animal Laboratory Diagnosis

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The grey mouse lemur: A non-human primate model for ageing studies

Cited by 147 publications

References 129 publications

Senescence or selective disappearance? Age trajectories of body mass in wild and captive populations of a small-bodied primate

Senescence or selective disappearance? Age trajectories of body mass in wild and captive populations of a small-bodied primate

Genomes

Lemurs

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