The green tea polyphenol (−)-epigallocatechin-3-gallate inhibits amyloid-β evoked fibril formation and neuronal cell death in vitro

Harvey, Benjamin S.; Musgrave, Ian; Ohlsson, Katharina S.; Fransson, Alfred; Smid, Scott D.

doi:10.1016/j.foodchem.2011.06.040

Cited by 34 publications

(25 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, polyphenols such as curcumin, myricetin, morin, quercetin, kaempferol (+)‐catechin, (−)‐epicatechin, nordihydroguaiaretic acid, tannic acid, and stilbenes have been investigated extensively . Furthermore, the role of different plant and food extracts has also been investigated, presenting satisfactory effects against Aβ toxicity …”

Section: Discussionmentioning

confidence: 99%

In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid‐β Kinetics and Neuroprotection

Hornedo-Ortega

Costa

Cerezo

et al. 2018

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid‐β Kinetics and Neuroprotection

Hornedo-Ortega

Costa

Cerezo

et al. 2018

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…There is a growing consensus in the literature that the frequently investigated polyphenols could be key molecules for the development of therapeutics or as a part of a prevention strategy for AD [ 10 , 11 , 12 , 13 , 14 ]. Polyphenols are present widely in fruits and vegetables.…”

Section: Introductionmentioning

confidence: 99%

Anti-Amyloidogenic Properties of Some Phenolic Compounds

et al. 2015

View full text Add to dashboard Cite

A family of 21 polyphenolic compounds consisting of those found naturally in danshen and their analogues were synthesized and subsequently screened for their anti-amyloidogenic activity against the amyloid beta peptide (Aȕ42) of Alzheimer's disease. After 24 h incubation with Aȕ42, five compounds reduced thioflavin T (ThT) fluorescence, indicative of their anti-amyloidogenic propensity (p < 0.001). TEM and immunoblotting analysis also showed that selected compounds were capable of hindering fibril formation even after prolonged incubations. These compounds were also capable of rescuing the yeast cells from toxic changes induced by the chemically synthesized Aȕ42. In a second assay, a Saccharomyces cerevisiae AHP1 deletant strain transformed with GFP fused to Aȕ42 was treated with these compounds and analyzed by flow cytometry. There was a significant reduction in the green fluorescence intensity associated with 14 compounds. We interpret this result to mean that the compounds had an anti-amyloid-aggregation propensity in the yeast and GFP-Aȕ42 was removed by proteolysis. The position and not the number of hydroxyl groups on the aromatic ring was found to be the most important determinant for the anti-amyloidogenic properties. OPEN ACCESSBiomolecules 2015, 5 506

show abstract

“…Accordingly, anti-inflammatory drugs [ 29 ] and antioxidative compounds [ 30 ] have been shown to prevent and slow down the onset of AD, through possessing antiamyloidogenic properties. Additionally, recent studies have shown that epigallocatechin gallate (EGCG) [ 31 ] and cannabinoids [ 32 ] can reduce the formation of A β fibrils and aggregates formation, while a hybrid of the AD drug tacrine, tacrine-6-ferulic acid dimer, was reported to alter the conformation of A β and block A β -induced cell death as its possible neuroprotective action [ 33 ]. In this study, ethyl acetate extract of GBR also altered A β formation ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

Germinated Brown Rice Alters Aβ(1-42) Aggregation and Modulates Alzheimer’s Disease-Related Genes in Differentiated Human SH-SY5Y Cells

Azmi

Ismail

et al. 2015

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

The pathogenesis of Alzheimer's disease involves complex etiological factors, of which the deposition of beta-amyloid (Aβ) protein and oxidative stress have been strongly implicated. We explored the effects of H2O2, which is a precursor for highly reactive hydroxyl radicals, on neurotoxicity and genes related to AD on neuronal cells. Candidate bioactive compounds responsible for the effects were quantified using HPLC-DAD. Additionally, the effects of germinated brown rice (GBR) on the morphology of Aβ(1-42) were assessed by Transmission Electron Microscopy and its regulatory effects on gene expressions were explored. The results showed that GBR extract had several phenolic compounds and γ-oryzanol and altered the structure of Aβ(1-42) suggesting an antiamyloidogenic effect. GBR was also able to attenuate the oxidative effects of H2O2 as implied by reduced LDH release and intracellular ROS generation. Furthermore, gene expression analyses showed that the neuroprotective effects of GBR were partly mediated through transcriptional regulation of multiple genes including Presenilins, APP, BACE1, BACE2, ADAM10, Neprilysin, and LRP1. Our findings showed that GBR exhibited neuroprotective properties via transcriptional regulation of APP metabolism with potential impact on Aβ aggregation. These findings can have important implications for the management of neurodegenerative diseases like AD and are worth exploring further.

show abstract

The green tea polyphenol (−)-epigallocatechin-3-gallate inhibits amyloid-β evoked fibril formation and neuronal cell death in vitro

Cited by 34 publications

References 45 publications

In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid‐β Kinetics and Neuroprotection

In Vitro Effects of Serotonin, Melatonin, and Other Related Indole Compounds on Amyloid‐β Kinetics and Neuroprotection

Anti-Amyloidogenic Properties of Some Phenolic Compounds

Germinated Brown Rice Alters Aβ(1-42) Aggregation and Modulates Alzheimer’s Disease-Related Genes in Differentiated Human SH-SY5Y Cells

Contact Info

Product

Resources

About