The green tea catechin, epigallocatechin gallate inhibits chikungunya virus infection

Weber, Christopher; Sliva, Katja; Rhein, Christine von; Kümmerer, Beate M.; Schnierle, Barbara S.

doi:10.1016/j.antiviral.2014.11.001

Cited by 108 publications

(82 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we have explored the in vitro antiviral capacity of different polyphenols, and shown that EGC, EGCG, and D inhibit WNV infection, and that the last two also inhibit DENV and ZIKV. Even more, in agreement with previous reports for viruses of different families (Ciesek et al, 2011; Calland et al, 2012, 2015; Huang et al, 2014; Weber et al, 2015; Carneiro et al, 2016), the antiviral activity of these compounds was only observed when the polyphenols were added during the early steps of the infection. Further analyses revealed that both, D and EGCG, act as virucidal agents by exhibiting a direct effect on WNV particles.…”

Section: Discussionsupporting

confidence: 92%

“…Polyphenols have also demonstrated potential antibacterial, antifungal, and antiviral activities. For instances, the antiviral effect of epigallocatechin gallate (EGCG), the most abundant polyphenol in green tea, has been already reported for several viruses: hepatitis C virus, chikungunya virus, hepatitis B virus, herpes simplex virus type 1 virus, influenza A virus, vaccinia virus, adenovirus, reovirus, vesicular stomatitis virus, and, very recently, for ZIKV (Ciesek et al, 2011; Calland et al, 2012, 2015; Huang et al, 2014; Weber et al, 2015; Carneiro et al, 2016). Likewise, other polyphenols have also been described to present antiviral activity, such as honokiol, baicalein, naringin, and quercetin (Zandi et al, 2011, 2012; Johari et al, 2012; Fang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus

et al. 2017

View full text Add to dashboard Cite

The Flavivirus genus contains important pathogens, such as West Nile virus (WNV), Zika virus (ZIKV), and Dengue virus (DENV), which are enveloped plus-strand RNA viruses transmitted by mosquitoes and constitute a worrisome threat to global human and animal health. Currently no licensed drugs against them are available, being, thus, still necessary the search for effective antiviral molecules. In this line, a novel antiviral approach (economical, simple to use, and environmental friendly) is the use of natural compounds. Consequently, we have tested the antiviral potential of different polyphenols present in plants and natural products, such as wine and tea, against WNV, ZIKV, and DENV. So that, we assayed the effect of a panel of structurally related polyphenols [delphinidin (D), cyanidin (Cy), catechin (C), epicatechin (EC), epigallocatechin (EGC), and epigallocatechin gallate (EGCG)] on WNV infection, and found that D and EGCG inhibited more effectively the virus production. Further analysis with both compounds indicated that they mainly affected the attachment and entry steps of the virus life cycle. Moreover, D and EGCG showed a direct effect on WNV particles exerting a virucidal effect. We showed a similar inhibition of viral production of these compounds on WNV variants that differed on acidic pH requirements for viral fusion, indicating that their antiviral activity against WNV is produced by a virucidal effect rather than by an inhibition of pH-dependent viral fusion. Both polyphenols also reduced the infectivity of ZIKV and DENV. Therefore, D and EGCG impair the infectivity in cell culture of these three medically relevant flaviviruses.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The virus was generated by in vitro-transcription of the plasmid pCHIKV-luci after Not I linearization, as described previously [34], followed by transfection of the RNA into BHK-21 cells using Lipofectamine® 2000 (Life Technologies). Supernatants containing virus were harvested 48 h later and the virus was amplified on BHK-21 cells.…”

Section: Methodsmentioning

confidence: 99%

Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry

Henß

Beck

Weidner

et al. 2016

Virol J

Self Cite

View full text Add to dashboard Cite

BackgroundChikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes high fever, rash, and recurrent arthritis in humans. It has efficiently adapted to Aedes albopictus, which also inhabits temperate regions and currently causes large outbreaks in the Caribbean and Latin America. Ebola virus (EBOV) is a member of the filovirus family. It causes the Ebola virus disease (EDV), formerly known as Ebola hemorrhagic fever in humans and has a mortality rate of up to 70 %. The last outbreak in Western Africa was the largest in history and has caused approximately 25,000 cases and 10,000 deaths. For both viral infections no specific treatment or licensed vaccine is currently available. The bis-hexasulfonated naphthylurea, suramin, is used as a treatment for trypanosome-caused African river blindness. As a competitive inhibitor of heparin, suramin has been described to have anti-viral activity.MethodsWe tested the activity of suramin during CHIKV or Ebola virus infection, using CHIKV and Ebola envelope glycoprotein pseudotyped lentiviral vectors and wild-type CHIKV and Ebola virus.ResultsSuramin efficiently inhibited CHIKV and Ebola envelope-mediated gene transfer while vesicular stomatitis virus G protein pseudotyped vectors were only marginally affected. In addition, suramin was able to inhibit wild-type CHIKV and Ebola virus replication in vitro. Inhibition occurred at early time points during CHIKV infection.ConclusionSuramin, also known as Germanin or Bayer-205, is a market-authorized drug, however shows significant side effects, which probably prevents its use as a CHIKV drug, but due to the high lethality of Ebola virus infections, suramin might be valuable against Ebola infections.

show abstract

“…There is no vaccine or medicine for this disease. Recent studies show that the main components of green tea, catechin and EGCG inhibit virus CHIKV infection (Weber et al 2015). …”

Section: Figure 1 Chikungunya Virus Infectionmentioning

confidence: 99%

Antiviral effects of green tea (<i>Camellia sinensis</i>) against pathogenic viruses in human and animals (a mini-review)

Mahmood¹,

Martínez²,

Aslam³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Background: Tea is the second most addictive worldwide after formulations containing caffeine in carbonated beverage. Green tea is made from leaves of the Camellia sinensis plant. In the repertoire of traditional Chinese medicine, green tea beverages have played a fundamental role associated with their culture. It has been suggested that green tea has a number of positive health benefits that are reviewed and discussed in this minireview. Materials and Methods:We performed a search using the key words "green tea" AND "antiviral" covering the last 10 years. The consulted data based were PubMed, ISI Web of Knowledge, Scopus, Reuters and Thomson. Results:The results of the searching greatly support that green tea presents both antibacterial and antiviral effects. The beneficial effects of green tea are mainly attributed to the presence of a type of polyphenols known as catechins and formed by several isomers including (-) -epigallocatechin gallate (EGCG), (-) -epigallocatechin, (-) -epicatechin gallate, (-) -epicatechin, and (+) -catechin. The catechins in green tea have a wide range of antiviral activity against a variety of viruses that act by interfering with its replication cycle. Conclusion: A detailed information on the antiviral activity of green tea in a number of different viruses show a promising future as a popular drink and also as a potential therapeutic agent.

show abstract

The green tea catechin, epigallocatechin gallate inhibits chikungunya virus infection

Cited by 108 publications

References 23 publications

Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus

Antiviral Properties of the Natural Polyphenols Delphinidin and Epigallocatechin Gallate against the Flaviviruses West Nile Virus, Zika Virus, and Dengue Virus

Suramin is a potent inhibitor of Chikungunya and Ebola virus cell entry

Antiviral effects of green tea (<i>Camellia sinensis</i>) against pathogenic viruses in human and animals (a mini-review)

Contact Info

Product

Resources

About