The Green ChemisTREE: 20 years after taking root with the 12 principles

Erythropel, Hanno C.; Zimmerman, Julie; Winter, Tamara M. de; Petitjean, L.; Melnikov, Fjodor; Lam, Chun Ho; Lounsbury, Amanda W.; Mellor, Karolina E.; Janković, Nina Z.; Tu, Qingshi; Pincus, Lauren N.; Falinski, Mark M.; Shi, Wenbo; Coish, Philip; Plata, Desirée L.; Anastas, Paul T.

doi:10.1039/c8gc00482j

Cited by 543 publications

(409 citation statements)

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“…With developing need towards greener approaches, the use and modification of traditional methodologies is the need of the present, and in such a circumstance, PEG might be the solvent of higher preference because of its versatile blessings as a green reaction media. Since the arrival of green chemistry, various green chemistry orientated synthetic methods have been progressed so one can synthesize a wide variety of compounds without or less environmental hazard . One such strategy which has pulled brilliant attention of researchers in the organic synthesis using benign reaction media.…”

Section: Introductionmentioning

confidence: 99%

Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives

Adole

Jagdale

et al. 2020

ChemistrySelect

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In the present investigation, an alluring green PEG‐400 mediated one‐pot synthesis of novel 2‐(2‐hydrazinyl)thiazole derivatives from 1,2,6,7‐tetrahydro‐8H‐indeno[5,4‐b]furan‐8‐one has been unveiled via a novel synthetic pathway. The application of PEG in organic reactions as a reaction media is one of the fantastic tools of green chemistry as reactions can be carried out under generous conditions limiting environmental peril and chemical waste. PEG‐400 is recognized as a low‐cost, non‐flammable, environmentally benign, recyclable, and richly available green solvent. A series of novel 2‐(2‐hydrazineyl)thiazole derivatives have been synthesized in good to excellent yield by using the green capability of PEG‐400 solvent. These newly synthesized compounds were tested for their antimicrobial and antioxidant activities. The results revealed that these compounds show good activities compared with the standard. Additionally, all the synthesized compounds exhibit negligible cytotoxicity as compared to the positive control. The structures of all novel compounds reported herein are established using FT‐IR, 1H NMR, 13C NMR, D2O exchange experiment and HRMS techniques.

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Section: Introductionmentioning

confidence: 99%

Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives

Adole

Jagdale

et al. 2020

ChemistrySelect

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“…Today, sustainability is becoming a key target in the fine chemical industry . However, the transfer from well‐established reactions and reagents to novel chemistries that tend to be more sustainable at the lab‐scale is not always straightforward.…”

Section: Introductionmentioning

confidence: 99%

Continuous‐Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex

Ötvös

Kappe

2020

ChemSusChem

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Reductions of amides and esters are of critical importance in synthetic chemistry, and there are numerous protocols for executing these transformations employing traditional batch conditions. Notably, strategies based on flow chemistry, especially for amide reductions, are much less explored. Herein, a simple process was developed in which neat borane dimethylsulfide complex (BH3⋅DMS) was used to reduce various esters and amides under continuous‐flow conditions. Taking advantage of the solvent‐free nature of the commercially available borane reagent, high substrate concentrations were realized, allowing outstanding productivity and a significant reduction in E‐factors. In addition, with carefully optimized short residence times, the corresponding alcohols and amines were obtained in high selectivity and high yields. The synthetic utility of the inexpensive and easily implemented flow protocol was further corroborated by multigram‐scale syntheses of pharmaceutically relevant products. Owing to its beneficial features, including low solvent and reducing agent consumption, high selectivity, simplicity, and inherent scalability, the present process demonstrates fewer environmental concerns than most typical batch reductions using metal hydrides as reducing agents.

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“…Pharmaceuticals successfully employed to fight degenerative diseases, immune disorder, infection, cancer or pain have played a fundamental role in the life expectancy increase during the last decades . The main components of these approved drugs are usually produced through multiple organic synthesis and purification steps, which requires large volumes of expensive and toxic reagents, as well as solvents . This is the reason why, in the small‐scale pharmaceutical industry, the amount of waste per product obtained is huge compared to that of bulk chemicals, which has a longer development time and optimization of the processes (see Figure ).…”

Section: Introductionmentioning

confidence: 99%

Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients

Cirujano

2019

ChemCatChem

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The latest strategies in the design and synthesis of metalorganic frameworks as heterogeneous catalysts in organic synthesis are compared with biocatalyzed transformations, as a step forward to a more convenient industrial production of pharmaceuticals. Relevant CÀ C and CÀ N bond forming reactions that are both chemo-and bio-catalyzed by synthetic MOFs and in vitro evolved and/or promiscuous enzymes with the aim of obtaining key bioactive scaffolds in a sustainable, competitive and cost-efficient manner, are thoroughly discussed in this mini review.

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The Green ChemisTREE: 20 years after taking root with the 12 principles

Abstract: A broad overview of the achievements and emerging areas in the field of Green Chemistry.

Cited by 543 publications

References 416 publications

Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives

Efficient Synthesis, Antibacterial, Antifungal, Antioxidant and Cytotoxicity Study of 2‐(2‐Hydrazineyl)thiazole Derivatives

Continuous‐Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex

Engineered MOFs and Enzymes for the Synthesis of Active Pharmaceutical Ingredients

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