The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer

Skandalis, Spyros S.; Kletsas, Dimitris; Kyriakopoulou, Dora; Stavropoulos, M.; Theocharis, Dimitrios A.

doi:10.1016/j.bbagen.2006.03.021

Cited by 79 publications

(66 citation statements)

References 42 publications

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“…On the other hand, the expression of 6-sulfotransferase did not show considerable differences in cancer. These observations suggested that the differential sulfation pattern observed in various cancers (2,(9)(10)(11)(12)(13)(14) is not due to the rapid biosynthetic rate of the cells, in other words, a wrong biosynthesis from the cells, but a well-controlled process to provide the cellular prerequisites, which in the case of cancer might be described as a microenvironment facilitating cell proliferation and migration. It is noteworthy that this 4-sulfotransferase transfers sulfate specifically in DS and this provides additional evidence that its decreased expression offers a cancer-promoting environment.…”

Section: Discussionmentioning

confidence: 98%

Alterations of glycosaminoglycan disaccharide content and composition in colorectal cancer: Structural and expressional studies

Kalathas

Theocharis²,

Bounias³

et al. 2009

Oncol Rep

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Abstract.The glycosaminoglycans are implicated in many processes important in the growth and progression of malignant tumors. In the present study glycosaminoglycans were purified from healthy, macroscopically normal and cancerous specimens of different anatomic sites and different stages of cancer and analyzed by FACE after chondroitinases and sulfatases digestion. The cancerous samples contained increased levels of 6-sulfated unsaturated disaccharides compared to macroscopically normal and healthy samples, the increase being stage-related. The differences in sulfation were found to be related to the anatomic site and the stage of cancer. RT-PCR analysis of 4-sulfotransferase mRNA revealed its presence in decreasing amounts as the stage of the cancer increased. Furthermore, the percent content of hyaluronan disaccharides was elevated in macroscopically normal samples compared to the cancerous, and in addition, it was much more elevated than that of healthy samples. Haluronan levels increase with stage in cancerous tissues. Therefore, it could be concluded that the glycosaminoglycans in colorectal cancer are biosynthetically directed to contribute in different ways depending on the cancer stage and anatomical site.

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Section: Discussionmentioning

confidence: 98%

Alterations of glycosaminoglycan disaccharide content and composition in colorectal cancer: Structural and expressional studies

Kalathas

Theocharis²,

Bounias³

et al. 2009

Oncol Rep

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“…There is a relation between versican with prostate cancer metastasis [17]. Studies on pancreatic cancer show the greatly increased in versican expression is associated with the malignancy of the tumor [10]. VCAN influences on metastatic phenotype in renal carcinoma [18] and human bladder cancer cell lines [19].…”

Section: Discussionmentioning

confidence: 99%

“…The role of versican as a main component of extracellular matrix is involved in cell adhesion, extracellular matrix assembly, cell migration and cell proliferation [6]. The upregulation of versican has been observed in a wide range of cancer such as breast [7], prostate [8], melanoma [9], pancreatic [10] and other cancers. In addition in a study on CRC by immunohistochemistry on VCAN protein revealed that VCAN was a strong prognostic indicator in stages II and III colon cancer [11].…”

Section: Introductionmentioning

confidence: 99%

VCAN gene expression and its association with tumor stage and lymph node metastasis in colorectal cancer patients

Hosseini¹,

Jafary²,

Hosseini³

et al. 2018

biomedicalresearch

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Introduction: Colorectal Cancer (CRC) is one of the most leading causes of cancer related mortalities and metastasis is the main cause of death in CRC patients. Versican (VCAN) is an Extra Cellular Matrix (ECM) proteoglycan that is involved in tumor progression and cancer metastasis. The overexpression of VCAN has been observed in some cancer. Objective: In this study we aimed to analyse VCAN gene expression in patients with colorectal cancer to

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“…In our work study, serum total glycosaminoglycans level of TCA-intoxicated rats showed a significant increase. Significant increase in GAGs have been demonstrated in many kinds of human cancers, viz, laryngeal [35], rectal [36], colon [37], gastric [38] and pancreatic [39].…”

Section: Discussionmentioning

confidence: 99%

Novel Panel of Early Diagnostic Markers for Experimental Hepatocellular Carcinoma

Nm¹,

MA²,

Ma³

2012

HEALTH

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Hepatocellular carcinoma (HCC) accounts for 80% to 90% of primary liver cancer and it is a major health problem worldwide, ranking the fifth most common cancer in the world. In the present study we aimed to explore new or highly pertinent rapid and sensitive markers for early diagnosis of hepatocellular malignant changes. Two groups of rats were used in this study, one served as control, the second as trichloroacetic acid (TCA) challenged group (0.5 g/kg/d for 5 days, sacrificed after 4 weeks). The results showed that TCA group had a significant increase in blood alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase ( ALP), and acetyl CoA synthase (ACAS) activities, total bilirubin, triglycerides, total glycosaminoglycans (TGAGs), parallel with alpha-fetoprotein (AFP). On the other hand, it induced a significant reduction in serum total lipoprotein lipase (TLPL) activity. The histopathological investigations of hepatic tissue confirmed these neoplastic changes induced by TCA. The three parameters (TGAGs level, TLPL and ACAS activities) can be added as new markers for early diagnosis of hepatocellular carcinoma and elevation of the sensitivity and specificity of AFP.

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The greatly increased amounts of accumulated versican and decorin with specific post-translational modifications may be closely associated with the malignant phenotype of pancreatic cancer

Cited by 79 publications

References 42 publications

Alterations of glycosaminoglycan disaccharide content and composition in colorectal cancer: Structural and expressional studies

Alterations of glycosaminoglycan disaccharide content and composition in colorectal cancer: Structural and expressional studies

VCAN gene expression and its association with tumor stage and lymph node metastasis in colorectal cancer patients

Novel Panel of Early Diagnostic Markers for Experimental Hepatocellular Carcinoma

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