The Great Pretender: Rectal Syphilis Mimic a Cancer

Ceretti, Andrea Pisani; Virdis, Matteo; Maroni, Nirvana; Arena, Monica; Masci, E.; Magenta, A; Opocher, Enrico

doi:10.1155/2015/434198

Cited by 13 publications

(11 citation statements)

References 12 publications

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“…Also, it is worth noting that atypical endoscopic image and other diseases, such as rectal syphilis and mucosal prolapsed syndrome, may mimic rectal cancer and should be include in differential diagnosis of an endoscopically likely rectal cancer [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Rectal ischemia causes mass formation, masquerading as rectal cancer

Fousekis

Aggeli

Gkogkos

et al. 2018

Oxford Medical Case Reports

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Rectal ischemia rarely occurs because of the rich vascular supply of the rectum, while endoscopic presentation of ischemic colitis always is not distinct and can uncommonly mimic malignant neoplasm. We present a case of a rectal ischemia, which presented with haematochezia and proctoscopy revealed a large ulcerating mass, masquerading as rectal cancer and obstructed the lumen of rectum. However, histological examinations showed only features for ischemic colitis and no evidence for malignancy. The patient was treated conservatively and 10 days later, new endoscopy showed complete disappearance of ulcerated mass, and new biopsies confirmed the initial diagnosis. Awareness and early diagnosis of ‘mass forming’ entity of ischemic colitis is very essential in order to carry out appropriate treatment and avoid severe complications.

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Section: Discussionmentioning

confidence: 99%

Rectal ischemia causes mass formation, masquerading as rectal cancer

Fousekis

Aggeli

Gkogkos

et al. 2018

Oxford Medical Case Reports

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“…Endoscopic findings of syphilitic anorectal disease are broad, ranging from proctitis and ulcers to pseudotumors [ 73 ]. Ulcers can be irregular and numerous, and two ulcers can be found, opposing one another, or can be eccentrically located [ 74 ].…”

Section: Methodsmentioning

confidence: 99%

A Comprehensive Review of Infectious Granulomatous Diseases of the Gastrointestinal Tract

Amarnath

Deeb

Philipose

et al. 2021

Gastroenterology Research and Practice

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A granuloma is defined as a localized inflammatory reaction or a hypersensitive response to a nondegradable product leading to an organized collection of epithelioid histiocytes. Etiologies of granulomatous disorders can be divided into two broad categories: infectious and noninfectious (autoimmune conditions, toxins, etc.) causes. The endless list of causalities may prove challenging for gastroenterologists and pathologists to formulate a list of clearly defined differentials. This is true when distinguishing these etiologies based on various clinical presentations and endoscopic and histological findings. We aim to provide a comprehensive review of some of the frequent and rare infectious granulomatous diseases of the gastrointestinal tract documented in the literature to date. We provide an overview of each infectious pathology with an emphasis on epidemiology, clinical presentation, and endoscopic and histologic findings, in addition to treatment.

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“…Lung involvement may manifest as an infiltration, pleural effusion, or pulmonary nodules 57 . Gastrointestinal disease may produce a mass or ulcerated lesions in the rectum 58,59 . Renal syphilis may produce nephrotic syndrome 16 .…”

Section: Clinical Featuresmentioning

confidence: 99%

“…57 Gastrointestinal disease may produce a mass or ulcerated lesions in the rectum. 58,59 Renal syphilis may produce nephrotic syndrome. 16 This revised definition of malignant syphilis must be updated to include these systemic manifestations.…”

Section: Systemic Manifestationsmentioning

confidence: 99%

Malignant syphilis: a new and revised definition

Karanfilian

Almohssen²,

Kapila

et al. 2022

Int J Dermatology

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Malignant syphilis is a rare, severe variant of secondary syphilis that primarily affects immunocompromised patients. Historically, the clinical presentation included a prodrome of constitutional symptoms followed by the development of characteristic skin lesions. The definition of malignant syphilis has not been updated since it was first described as only a cutaneous manifestation. In recent years, syphilis has reemerged as a major public health issue, particularly in men who have sex with men (MSM) and patients with HIV. With increasing rates of syphilis in the HIV‐positive population, the systemic manifestations of malignant syphilis have become more apparent. We propose a revised definition and elucidate why the term malignant syphilis should be expanded to include systemic manifestations, stressing musculoskeletal, central nervous system, ocular, ear, cardiovascular, rectal, liver, lung, and renal involvement. This updated definition is dramatically expanded to reflect its systemic manifestations. Recognition of these manifestations may prevent devastating long‐term effects.

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The Great Pretender: Rectal Syphilis Mimic a Cancer

Cited by 13 publications

References 12 publications

Rectal ischemia causes mass formation, masquerading as rectal cancer

Rectal ischemia causes mass formation, masquerading as rectal cancer

A Comprehensive Review of Infectious Granulomatous Diseases of the Gastrointestinal Tract

Malignant syphilis: a new and revised definition

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