The graduated embryo score (GES) and total graduated embryo score (TGES) were not associated to endometriosis

Genro, V.; Souza, Célia Mariana Barbosa de; Luz, L. Guedes da; Silva, D.; Andreoli, C; Cunha-Filho, JS

doi:10.1016/j.fertnstert.2009.07.1103

Cited by 1 publication

(3 citation statements)

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“…There was also no difference observed when comparing patients with endometriosis according to the degree of severity of the disease. To check for differences between the groups, we performed a secondary analysis considering that embryos with scores higher than 70 points have a higher implantation rate (11). Among the 109 control patients, 42 (38.5%) had mean GES scores greater than 70 compared with 20 patients from the 53 patients with endometriosis (37.7%).…”

Section: Resultsmentioning

confidence: 99%

“…Sample size was calculated from a pilot study conducted in 2009, and 70 patients were needed to have a 90% chance of detecting, at a 5% significance level, a decrease in the primary outcome measure from 92 in the control group to 85 in the experimental group. 18 In this pilot study, developed by Genro et al (2009), 11 a GES value of 92 ± 12 was recorded in the control group without endometriosis, compared with 85 ± 9 in those infertile patients with endometriosis.…”

Section: Methodsmentioning

confidence: 94%

“…3,9,10 Embryo quality evaluation for the selection and transfer into the uterus is a critical step in IVF treatment to maximize the probability of pregnancy, especially when we choose to transfer only one embryo. 11,12 Previous retrospective studies have evaluated embryo quality in patients with endometriosis and observed a decrease in their morphological parameters, as well as a higher percentage of abnormal embryos in these patients. 13,14 Furthermore, several recent studies have shown a decreased oocyte quality and number in endometriotic patients.…”

Section: Introductionmentioning

confidence: 99%

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The Graduated Embryo Score of Embryos from Infertile Women with and without Peritoneal Endometriosis

Caran

Genro

Souza

et al. 2021

Rev Bras Ginecol Obstet

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Objective To determine embryo quality (mean graduated embryo score [GES]) in infertile patients with endometriosis undergoing in vitro fertilization with embryo transfer (IVF-ET) compared with infertile patients without endometriosis. Methods A case-control study was performed comparing 706 embryos (162 patients) divided into 2 groups: 472 embryos derived from patients without endometriosis (n = 109, infertile patients with tubal infertility) and 234 embryos from patients in the study group (n = 53, infertile patients with peritoneal endometriosis). All patients were subjected to IVF using an oestradiol-antagonist-recombinant follicle-stimulating hormone (FSH) protocol for ovarian stimulation. The mean GES was performed to evaluate all embryos at 3 points in time: 16 to 18 hours, 25 to 27 hours, and 64 to 67 hours. Embryo evaluation was performed according to the following parameters: fragmentation, nucleolar alignment, polar body apposition, blastomere number/morphology, and symmetry. The primary outcome measure was the mean GES score. We also compared fertilization, implantation, and pregnancy rates. Results Although the number of embryos transferred was greater in patients with endometriosis than in the control group (2.38 ± 0.66 versus 2.15 ± 0.54; p = 0.001), the mean GES was similar in both groups (71 ± 19.8 versus 71.9 ± 23.5; p = 0.881). Likewise, the fertilization rate was similar in all groups, being 61% in patients with endometriosis and 59% in the control group (p = 0.511). No significant differences were observed in the implantation (21% versus 22%; [p = 0.989]) and pregnancy rates (26.4% versus 28.4%; p = 0.989). Conclusion Embryo quality measured by the mean GES was not influenced by peritoneal endometriosis. Likewise, the evaluated reproductive outcomes were similar between infertile patients with and without endometriosis.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 94%