The GRACE Checklist for Rating the Quality of Observational Studies of Comparative Effectiveness: A Tale of Hope and Caution

Dreyer, Nancy A; Velentgas, Priscilla; Westrich, Kimberly; Dubois, Robert W.

doi:10.18553/jmcp.2014.20.3.301

Cited by 92 publications

(92 citation statements)

References 19 publications

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“…As there is no standard scale to assess quality in observational studies, we used a modified version of the GRACE checklist to perform the critical appraisal of the included studies (Supplementary Table S2) …”

Section: Methodsmentioning

confidence: 99%

“…A P value of less than 0.05 as calculated by Egger's test and asymmetry of Begg's funnel plot was used to define publication bias. If publication bias existed, the trim and fill approach was implemented in order to generate an estimated pooled OR that accounts for unpublished negative findings . A forest plot with each study's included OR as well as the pooled OR along with 95% CIs, with the weight of each OR indicated by the relative size of the study, was used to visualize the range of effects.…”

Section: Methodsmentioning

confidence: 99%

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Comparison of hypersensitivity rates to intravenous and intramuscular PEG‐asparaginase in children with acute lymphoblastic leukemia: A meta‐analysis and systematic review

Hasan

Shaikh

Rassekh

et al. 2016

Pediatric Blood & Cancer

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Background: Pegylated-asparaginase (PEG-ASP) is a critical treatment for pediatric acute lymphoblastic leukemia (ALL) and has traditionally been delivered via intramuscular (IM) injection. In an attempt to reduce pain and anxiety, PEG-ASP has increasingly been delivered via intravenous (IV) administration. The study objective was to perform a meta-analysis and systematic review to compare and generate pooled hypersensitivity rates for IM and IV PEG-ASP. Methods:A systematic literature search was conducted for all epidemiological studies that investigated IV and IM hypersensitivity rates for pediatric ALL. Included studies were critically appraised using the GRACE checklist. Pooled estimates and odds ratios with 95% confidence intervals (CIs) for IM and IV hypersensitivity rates were derived based on either a random or fixed effects model. Results:Four studies satisfied the inclusion criteria and were of adequate quality. The random effects pooled hypersensitivity rates were 23.5% (95% CI 14.7-33.7) and 8.7% (95% CI 5.4-12.8) for IV and IM, respectively. The fixed effects pooled odds ratio after adjusting for publication bias was 2.49 (95% CI 1.62-3.83), indicating a significantly higher risk of hypersensitivity for IV over IM PEG-ASP. This risk is far more pronounced for high-risk (HR) patients compared with standardrisk (SR) patients (IV vs. IM: HR ↑35.2% and SR ↓2.9%). Conclusions:Although administering PEG-ASP through IV is preferable for patients, it poses a significantly higher risk of hypersensitivity when compared with IM administration, especially for HR patients. We recommend pediatric oncologists consider treating patients with HR pediatric ALL with IM PEG-ASP to reduce the risk of hypersensitivity. K E Y W O R D Sacute lymphoblastic leukemia, hypersensitivity, intramuscular, intravenous, meta-analysis, PEGasparaginase Abbreviations: ALL, acute lymphoblastic leukemia; B-ALL, B-cell acute lymphoblastic

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Comparison of hypersensitivity rates to intravenous and intramuscular PEG‐asparaginase in children with acute lymphoblastic leukemia: A meta‐analysis and systematic review

Hasan

Shaikh

Rassekh

et al. 2016

Pediatric Blood & Cancer

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“…Although the approaches to scoring using this checklist have not been formalized, it has been suggested that if a paper addresses most of the items on the checklist, it can be deemed a reliable source (Dreyer, Velentgas, Westrich, & Dubois, 2014). …”

Section: Methodsmentioning

confidence: 99%

Adaptation to poststroke visual field loss: A systematic review

Howard

Rowe

2018

Brain and Behavior

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AimTo provide a systematic overview of the factors that influence how a person adapts to visual field loss following stroke.MethodA systematic review was undertaken (data search period 1861–2016) inclusive of systematic reviews, randomized controlled trials, controlled trials, cohort studies, observational studies, and case controlled studies. Studies including adult subjects with hemifield visual field loss, which occured as a direct consequence of stroke, were included. Search terms included a range of MESH terms as well as alternative terms relating to stroke, visual field loss, visual functions, visual perception, and adaptation. Articles were selected by two authors independently, and data were extracted by one author, being verified by the second. All included articles were assessed for risk of bias and quality using checklists appropriate to the study design.ResultsForty‐seven articles (2,900 participants) were included in the overall review, categorized into two sections. Section one included seventeen studies where the reviewers were able to identify a factor they considered as likely to be important for the process of adaptation to poststroke visual field loss. Section two included thirty studies detailing interventions for visual field loss that the reviewers deemed likely to have an influence on the adaptation process. There were no studies identified which specifically investigated and summarized the factors that influence how a person adapts to visual field loss following stroke.ConclusionThere is a substantial amount of evidence that patients can be supported to compensate and adapt to visual field loss following stroke using a range of strategies and methods. However, this systematic review highlights the fact that many unanswered questions in the area of adaptation to visual field loss remain. Further research is required on strategies and methods to improve adaptation to aid clinicians in supporting these patients along their rehabilitation journey.

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“…Two reviewers assessed the methodological quality of the studies independently. RCTs were assessed using the Cochrane risk of bias tool, which addresses seven specific domains: random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment, incomplete outcome data, selective outcome reporting, and “anything else.” The Good ReseArch for Comparative Effectiveness (GRACE) checklist, which is an 11‐item tool, was used to assess the quality of data and methods of the observational studies …”

Section: Methodsmentioning

confidence: 99%

Silver delivery approaches in the management of partial thickness burns: A systematic review and indirect treatment comparison

Nherera

Trueman

Roberts³

et al. 2017

Wound Repair Regeneration

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Silver‐containing products play an important role in the management of burn wound infections. We sought to compare the efficacy of commonly used silver delivery approaches including nanocrystalline silver, silver‐impregnated hydrofiber dressing, and silver‐impregnated foam dressing as the main products in the management of partial thickness burns. A systematic review was performed by searching PubMed, EMBASE, Cochrane, and other databases to identify relevant randomized controlled trials and observational studies. Due to the paucity of direct head‐to‐head trials, an indirect treatment comparison was performed. The use of nanocrystalline silver was associated with a statistically significant reduction in length of stay when compared to silver‐impregnated hydrofiber dressing (p = 0.027) and a shorter time to healing when compared to silver‐impregnated foam dressing (p = 0.0328). There were no statistically significant differences in infection rates and surgical procedures between nanocrystalline silver, silver‐impregnated hydrofiber dressing, and silver‐impregnated foam dressing; however, nanocrystalline silver was found to be the most beneficial for all the outcomes, including infection rates and surgical procedures, according to the Monte Carlo simulation method. In conclusion, current evidence from the published literature suggests that where the clinical and microbiological priority is to get in control of infection quickly it would seem prudent to use the most potent silver delivery system, which is nanocrystalline silver. Nanocrystalline silver may offer both clinical and economic benefits compared to alternative treatments in the management of patients with mixed burns that are at high risk of infection.

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The GRACE Checklist for Rating the Quality of Observational Studies of Comparative Effectiveness: A Tale of Hope and Caution

Abstract: BACKGROUND: While there is growing demand for information about comparative effectiveness (CE), there is substantial debate about whether and when observational studies have sufficient quality to support decision making.

Cited by 92 publications

References 19 publications

Comparison of hypersensitivity rates to intravenous and intramuscular PEG‐asparaginase in children with acute lymphoblastic leukemia: A meta‐analysis and systematic review

Comparison of hypersensitivity rates to intravenous and intramuscular PEG‐asparaginase in children with acute lymphoblastic leukemia: A meta‐analysis and systematic review

Adaptation to poststroke visual field loss: A systematic review

Silver delivery approaches in the management of partial thickness burns: A systematic review and indirect treatment comparison

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