The “GP” Mechanical Thrombectomy Device

Pearce, Gillian; Perkinson, N.D.; Wong, John; Burley, Matthew; Spence, Julian; Brookfield, Paul; Murcott, David

doi:10.1016/j.jstrokecerebrovasdis.2008.11.011

Cited by 7 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using this mathematical technique, we can calculate, for example, values required for suction pressure in clot extraction for a chosen radius of GP ATD. Such values have been computed for a range of different diameters of GP devices, 36 and have been found to compare favorably with values obtained experimentally.…”

mentioning

confidence: 72%

See 1 more Smart Citation

In Vitro Testing of a New Aspiration Thrombus Device

Pearce¹,

Perkinson²,

Wong³

et al. 2010

Journal of Stroke and Cerebrovascular Diseases

Self Cite

View full text Add to dashboard Cite

mentioning

confidence: 72%

“…This flow pattern is associated with low forces at the periphery of the device reducing the risk of arterial collapse with higher suction pressures. [26][27][28][29][30][31][32][33][34] In addition to mechanical thrombectomy, the device also allows delivery of thrombolytic agents to the clot. This could further improve efficiency of clot removal.…”

mentioning

confidence: 99%

In Vitro Testing of a New Aspiration Thrombus Device

Pearce¹,

Perkinson²,

Wong³

et al. 2010

Journal of Stroke and Cerebrovascular Diseases

Self Cite

View full text Add to dashboard Cite

“…Depending on the volume of modelled thrombus, part of daughter branches may be blocked as well ( Figure 2). Since thrombus volumes observed in the coronary arteries are quite variable [16,20,21,24,25], in this study four different thrombus volumes (56, 67, 80 and 95 mm 3 ) were modeled. In order to model the thrombus aspiration, a two phase flow approach was applied following our previous investigations [13].…”

Section: Methodsmentioning

confidence: 99%

“…The literature studies were based on either analytical modelling [14,15,16] or experimental tests [17,18,19].…”

Section: Introductionmentioning

confidence: 99%

Performance of a thrombectomy device for aspiration of thrombus with various sizes based on a computational fluid dynamic modeling

Soleimani

Dubini

Pennati

2016

Biomedical Engineering / Biomedizinische Technik

View full text Add to dashboard Cite

It is important to thoroughly remove the thrombus within the course of aspiration thrombectomy; otherwise, it may lead to further embolization. The performance of the aspiration thrombectomy device with a generic geometry is studied through the computational approach. In order to model the thrombus aspiration, a real left coronary artery is chosen while thrombi with various sizes are located at the bifurcation area of the coronary artery and, depending on the size of the thrombus, it is stretched toward the side branches. The thrombus occupies the artery resembling the blood current obstruction in the coronary vessel similar to the situation that leads to heart attack. It is concluded that the aspiration ability of the thrombectomy device is not linked to the thrombus size; it is rather linked to the aspiration pressure and thrombus age (organized versus fresh thrombus). However, the aspiration time period correlates to the thrombus size. The minimum applicable aspiration pressure is also investigated in this study.

show abstract

“…It does not enter or disrupt the clot and allows aspiration during clot retrieval, reducing the risk of loose fragments. The vortex pattern flow generated by the GPTAD during suction is associated with low forces at the periphery of the device reducing the risk of arterial collapse [9–11]. An earlier study [12] demonstrated (i) that the GPTAD (previously called the GP MTD) can be effectively maneuvered though a model of the larger intracerebral arteries, (ii) that there is a correlation between the pressure required for extraction and the mass of the thrombus, (iii) that thrombus removal via the GPTAD can be further enhanced by the addition of alteplase to the perfusate, and (iv) that the use of the GPTAD does not damage the arterial wall of abattoir porcine artery walls studied in-vitro with suction pressures of up to 30 KPa.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device

Tennuci

Pearce

Wong

et al. 2011

Stroke Research and Treatment

Self Cite

View full text Add to dashboard Cite

Introduction. This paper compares different approaches to recanalization in a model of the middle cerebral artery (MCA). Methods. An occlusive thrombus (lamb's blood) was introduced into the MCA of a model of the cerebral circulation perfused with Hartmann's solution (80 pulsations/min, mean pressure 90 mm Hg). Three methods of clot retrieval were tested: thrombus aspiration via a 4F catheter (n = 26), thrombus aspiration via the GP thrombus aspiration device (GPTAD) (n = 30), and mechanical thrombectomy via the Solitaire Device (n = 30). Results. Recanalization rate was similar for all 3 approaches (62%, 77%, and 85%). Time to recanalization was faster with aspiration devices (41 SD 42 s for 4F and 61 SD 21 s for GPTAD) than with the Solitaire (197 SD 64 s P < .05 Kruksal-Wallis). Clot fragmentation was the same in the Solitaire (23%) and the GPTAD (23%), but higher with the 4F (53%, P < .05). Conclusion. In this model, thrombus aspiration was faster than mechanical thrombectomy, and similarly effective at recanalization. These results should be confirmed in vivo.

show abstract

The “GP” Mechanical Thrombectomy Device

Cited by 7 publications

References 10 publications

In Vitro Testing of a New Aspiration Thrombus Device

In Vitro Testing of a New Aspiration Thrombus Device

Performance of a thrombectomy device for aspiration of thrombus with various sizes based on a computational fluid dynamic modeling

Comparison of the Effectiveness of Three Methods of Recanalization in a Model of the Middle Cerebral Artery: Thrombus Aspiration via a 4F Catheter, Thrombus Aspiration via the GP Thromboaspiration Device, and Mechanical Thrombectomy Using the Solitaire Thrombectomy Device

Contact Info

Product

Resources

About