The Good pH probe: non-invasive pH in-line monitoring using Good buffers and Raman spectroscopy
David Heinrich Müller,
Marieke Börger,
Julia Thien
et al.
Abstract:In bioprocesses, the pH value is a critical process parameter that requires monitoring and control. For pH monitoring, potentiometric methods such as pH electrodes are state of the art. However, they are invasive and show measurement value drift. Spectroscopic pH monitoring is a non-invasive alternative to potentiometric methods avoiding this measurement value drift. In this study, we developed the Good pH probe, which is an approach for spectroscopic pH monitoring in bioprocesses with an effective working ran… Show more
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