The gonadotropin-releasing hormone (Gnrh) gene maps to mouse chromosome 14 and identifies a homologous region on human chromosome 8

Abstract

The murine gonadotropin-releasing hormone (Gnrh) locus has been mapped to mouse chromosome 14 using a mouse x Chinese hamster somatic cell hybrid panel. The equivalent human locus, known as luteinizing hormone-releasing hormone (LHRH), has been previously mapped to 8p21-8p11.2. Four other loci mapping to the human chromosome 8 short arm have been mapped to mouse chromosome 8; two of these (PLAT, GSR) lie proximal to LHRH, and two (LPL, DEF1) lie distal to LHRH. The localization of Gnrh, the murine homolog of LHRH, to mouse chromosome 14 therefore defines a hitherto unrecognized block of homology between man and mouse. Furthermore, it indicates that the region of homology between the human chromosome 8 short arm and mouse chromosome 8 is composed of two separate blocks.

Molecular cloning of mouse canp3, the gene associated with limb-girdle muscular dystrophy 2A in human

“…The panel is composed of 26 hybrids having a different subset of mouse chromosomes (Williamson et al 1991). The PCR results indicated that canp3 maps either to mouse Chromosomes (Chrs) 2 or 4 (data not shown), but did not allow distinction between these two chromosomes, since unfortunately all hybrids carrying mouse Chr 2 also carry Chr 4 and vice versa (P. Avner personal communication).…”

Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors

“…The gene encoding GnRH has been localized to a single locus on chromosome 8 in the human (Yang-Feng et al, 1986) and on chromosome 14 in the mouse (Williamson et al, 1991). Its sequence was originally isolated and identified using a cDNA library derived from human placenta, one of several extrahypothalamic tissues known to synthesize GnRH (Khodr and Siler-Khodr, 1980;Tan and Rousseau, 1982).…”

Report of the committee on the genetic constitution of chromosome 8

“…BMP2 and 3 map to chromosomes 20 and 4 respectively and arc members of the TGFB family while BMP1 appears to be a regulatory protein. BMP1 maps to human chromosome 8 and to mouse chromosome 14, which together with the reports of Todd et al (Todd et al, 1991) and Williamson et al (Williamson et al, 1991) defines a new man-mouse syntenic group on those two chromosomes.…”