The Golgi Apparatus: A Key Player in Innate Immunity

Abstract

The Golgi apparatus, long recognized for its roles in protein processing and vesicular trafficking, has recently been identified as a crucial contributor to innate immune signaling pathways. This review discusses our expanding understanding of the Golgi apparatus’s involvement in initiating and activating these pathways. It highlights the significance of membrane connections between the Golgi and other organelles, such as the endoplasmic reticulum, mitochondria, endosomes, and autophagosomes. These connections are vital for the efficient transmission of innate immune signals and the activation of effector responses. Furthermore, the article delves into the Golgi apparatus’s roles in key immune pathways, including the inflammasome-mediated activation of caspase-1, the cGAS-STING pathway, and TLR/RLR signaling. Overall, this review aims to provide insights into the multifunctional nature of the Golgi apparatus and its impact on innate immunity.

Selective Termination of Autophagy-Dependent Cancers

“…PIKFYVE inhibition also affects the innate immunity response and release of cytokines by virtue of the role of PIKFYVE in vesicular trafficking [118,119]. PIKFYVE inhibitors upregulate expression of inflammatory chemokines [9,120], particularly in combination with an immune checkpoint inhibitor [9,85].…”