The “Golden Age” of prostate brachytherapy: A cautionary tale

Aronowitz, Jesse N.

doi:10.1016/j.brachy.2007.12.004

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Local brachytherapy with surgically implanted radioactive emitters is a very widely used method for the treatment of localized cancer lesions, especially in the case of prostate cancer but also for breast, ovarian, and other cancers. 9,10 Local application largely eliminates the radiation burden of healthy tissues when high radiation doses are deployed to the site of implantation. The odds are that the enclosed emitter must be surgically implanted and, after treatment, surgically removed.…”

Section: Introductionmentioning

confidence: 99%

New binary thermoresponsive polymeric system for local chemoradiotherapy

Hrubý

Kučka

Macková

et al. 2008

J of Applied Polymer Sci

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Radiolabeled thermoresponsive polymers (TRPs) with cloud-point temperatures between room temperature and body temperature may have an advantage for local radiotherapeutical applications because TRPs may be isotopically labeled in solution at room temperature and injected as a solution, and at the site of application, the polymers form a depo because of phase separation at body temperature. A new polymeric drugdelivery system designed for combined local chemoradiotherapy with an injectable TRP bearing a radionuclide and the hydrophobic moiety doxorubicin (DOX) was synthesized and characterized. In the system, DOX served as an antiproliferative agent with known synergic effects with ionizing radiation and the hydrophobic moiety controlling bioerosion and elimination of the system at the same time. DOX was bound to the polymer carrier by a hydrolytically labile N-glycosylamine bond. Hydrolysis of the N-glycosylamine bond thus controlled the DOX release and dissolution of the system in the model aqueous milieu. DOX was slowly released during incubation in aqueous milieu at 37 C, which caused complete dissolution of the bioerodable polymer within about 2 weeks. The model radionuclide iodine 125, bound to a small amount of poly(N-isopropylacrylamide-co-N-methacryloyl tyrosinamide), was retained in the separated phase and also slowly dissolved during the incubation.

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Section: Introductionmentioning

confidence: 99%

New binary thermoresponsive polymeric system for local chemoradiotherapy

Hrubý

Kučka

Macková

et al. 2008

J of Applied Polymer Sci

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“…Radiogold grains were introduced in the 1950s. Their use declined after the introduction of 125 I, but they remained a favored isotope for prostate implantation in Houston and Iowa until the 1990s [10]. Radiogold grains are still occasionally implanted in recurrent tumors of the oral cavity, oropharynx, neck nodes, and vagina.…”

Section: Identification Of Implanted Sourcesmentioning

confidence: 99%

Identification and Management of Persistently Active Brachytherapy Seed Implants

Aronowitz

Clark

Mota

et al. 2009

American Journal of Roentgenology

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“…Therefore, 131 Cs will do little to advance the field of brachytherapy, but instead it has the potential to do significant harm. The open brachytherapy techniques using 198 Au and 125 I seeds 40e50 years ago were seriously dosimetrically inadequate and therapeutically ineffective (16,17). Those deficiencies virtually ended permanent seed brachytherapy treatment for many years.…”

mentioning

confidence: 99%

Counterpoint: Cesium-131: Not ready for prime time

Butler

2009

Brachytherapy

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The “Golden Age” of prostate brachytherapy: A cautionary tale

Cited by 6 publications

References 22 publications

New binary thermoresponsive polymeric system for local chemoradiotherapy

New binary thermoresponsive polymeric system for local chemoradiotherapy

Identification and Management of Persistently Active Brachytherapy Seed Implants

Counterpoint: Cesium-131: Not ready for prime time

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