The GnRH antagonist acyline prevented ovulation, but did not affect ovarian follicular development or gestational corpora lutea in the domestic cat

Risso, Analía Lorena; Valiente, C.; Corrada, Yanina Alejandra; Romero, Guadalupe García; Blanco, Paula Graciela; Sota, Pablo Elías de la; Diaz, J.D.; Gobello, Cristina

doi:10.1016/j.theriogenology.2010.01.010

Cited by 7 publications

(13 citation statements)

References 12 publications

(25 reference statements)

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“…In these female cats, P 4 serum concentrations were within normal range for feline pregnancy during the 14 days of follow‐up after treatments (Risso et al. ). Thus, acyline may not have affected luteal function at any stage of pregnancy.…”

Section: Effects On Luteal Phase Of the Pregnant Femalementioning

confidence: 86%

“…Oestrous behaviour was not affected by treatment (Risso et al. ) and all queens were mated with a fertile tomcat, but ovulation and pregnancy did not occur.…”

Section: Effects On Follicular Phase and Ovulationmentioning

confidence: 99%

“…More recently, after a 25-year interval, some pharmacokinetic, endocrine and clinical reports appeared using the safer and more potent third-generation antagonists (e.g. cetrorelix, antide and acyline) in domestic dogs and cats (Schwahn et al 2000;Pelican et al 2005Pelican et al , 2008Valiente et al 2007Valiente et al , 2009aGarcı´a Romero et al 2009, 2012aRisso et al 2010).…”

Section: New Gnrh Antagonists In Domestic Dog and Cat Reproductionmentioning

confidence: 99%

“…A number of randomized controlled trials were carried out using a single subcutaneous dose of the third-generation GnRH antagonist acyline (Contraception & Reproductive Health Branch Center for Population Research, NIH, Bethesda, MD, USA), and some endocrine and clinical data in domestic dogs and cats are now available and summarized in the different sections below (Valiente et al 2007(Valiente et al , 2009aGarcı´a Romero et al 2009, 2012aRisso et al 2010).…”

Section: New Gnrh Antagonists In Domestic Dog and Cat Reproductionmentioning

confidence: 99%

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Effects of GnRH Antagonists vs Agonists in Domestic Carnivores, a Review

Gobello

2012

Reprod Domestic Animals

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Contents Gonadotrophin‐releasing hormone (GnRH) stimulates the pituitary secretion of both luteinizing and follicle‐stimulating hormones, and thus controls the hormonal and reproductive functions of the gonads. GnRH analogs, which include agonists and antagonists, have been produced by amino acid substitutions within the native GnRH molecule resulting in greater potency and a longer duration of effectiveness. While the initial antagonists produced significant side effects, more recent potent, long‐acting, water‐soluble, low histamine‐release third‐generation compounds such as cetrorelix, abarelix, azaline B and acyline have appeared. Differently to GnRH agonists, antagonists competitively block and inhibit GnRH‐induced GnRH receptor gene expression leading to an immediate, dose‐dependent, pituitary suppression without an initial stimulation of the gonadal axis. The aims of this review are to compare the effects of GnRH agonists vs antagonists and to describe the existing literature concerning new antagonists in domestic carnivores. In male dogs, a single subcutaneous dose of acyline safely and reversibly decreased serum gonadotrophins and testosterone concentrations for 9 days and prevented physiological response of gonadal the axis to agonistic challenge for 14 days. The same protocol reversibly impaired spermiogenesis, spermatocytogenesis and semen quality in both cats and dogs. In females, third‐generation GnRH antagonists prevented ovulation and interrupted pregnancy in canids but not in felids. During anestrus, a single acyline injection exhibited limited prevention of the ‘flare‐up’ effect in GnRH agonist‐implanted bitches. Although GnRH antagonists appear to have a promising future in domestic carnivores reproduction, the information is still scarce and further work is needed before they can be widely recommended.

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Section: Effects On Luteal Phase Of the Pregnant Femalementioning

confidence: 86%

“…Oestrous behaviour was not affected by treatment (Risso et al. ) and all queens were mated with a fertile tomcat, but ovulation and pregnancy did not occur.…”

Section: Effects On Follicular Phase and Ovulationmentioning

confidence: 99%

Section: New Gnrh Antagonists In Domestic Dog and Cat Reproductionmentioning

confidence: 99%

Section: New Gnrh Antagonists In Domestic Dog and Cat Reproductionmentioning

confidence: 99%

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Effects of GnRH Antagonists vs Agonists in Domestic Carnivores, a Review

Gobello

2012

Reprod Domestic Animals

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“…, , ; Risso et al. ), only one study describes the use in tom cats (Garcia Romero et al. ) so that it can be stated that at the moment, GnRH antagonists are predominantly of scientific interest and – although results are promising – are lacking broad clinical experience.…”

Section: Gonadotropin‐releasing Hormone Antagonistsmentioning

confidence: 99%

Suppression of Fertility in Adult Cats

Goericke-Pesch

Wehrend

Georgiev

2014

Reprod Domestic Animals

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Contents Cats are animals with highly efficient reproduction, clearly pointing to a need for suppression of fertility. Although surgical contraception is highly effective, it is not always the method of choice. This is predominantly because it is cost‐intensive, time‐consuming and irreversible, with the latter being of major importance for cat breeders. This article reviews the use of progestins, scleroting agents, immunocontraception, melatonin, GnRH antagonists and finally, GnRH agonists, in adult male and female cats in detail, according to the present state of the art. By now, various scientific and clinical options are available for the suppression of fertility in adult cats and the decision as to which should be chosen – independent of the legal registration of any state – depends on different facts: (i) feral or privately owned animal? (ii) temporary or permanent suppression of fertility wanted/needed? (iii) sex of the animal? New effective and available methods for hormonal contraception include melatonin implants for short‐term post ponement of oestrus in adult queens and slow‐release GnRH‐agonist implants containing deslorelin (Suprelorin®) for short‐ and long‐term contraception in male and female companion and breeding cats.

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