The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14 094 cases and 17 760 controls

Bagos, Pantelis G.; Elefsinioti, Antigoni; Nikolopoulos, Georgios K.; Hamodrakas, Stavros J.

doi:10.1097/hjh.0b013e328011db24

Cited by 65 publications

(54 citation statements)

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“…In recent years many studies have reported a correlation between GNB3-C825T and EH in Caucasian, African, South American and Asian populations. Our analysis showed that the GNB3-C825T allele was associated with EH in the overall population, which is in agreement with the results of a previous multi-ethnic population meta-analysis (Bagos et al, 2007). These authors reported that TT versus CC + CT: OR=1.08, 95% CI: 1.01-1.15, P<0.001 and TT + CT versus CC: OR=1.17, 95% CI: 1.06-1.29, P<0.001.…”

Section: Discussionsupporting

confidence: 82%

Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects

Zheng

Cui

et al. 2013

Biol. Res.

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Purpose: The G-protein β3-subunit gene C825T polymorphism (GNB3-C825T) has been reported to be associated with essential hypertension (EH), but results from previous studies are conflicting. The present study aimed at investigating the association between this polymorphism and risk of EH using a meta-analysis on the published studies. Materials and Methods: PubMed, Embase, CBM (China Biological Medicine Database), Wanfang and VIP databases were searched to identify eligible studies published in English and Chinese before March 2013. Data were extracted using standardized methods. The association was assessed by the odds ratio (OR) with 95% confidence intervals (CI). Begg's test was used to measure publication bias. Results: A total of 40 case-control studies containing 16,518 EH patients and 20,284 controls were involved in this meta-analysis. Overall, a significant association was found between GNB3 C825T polymorphism and risk of EH when all studies were pooled with a random-eff ects model for T versus C (OR=1.09, 95% CI: 1.04-1.19). In the subgroup analysis, the same association was found in overall Caucasian (T versus C, OR=1.16, 95% CI 1.08-1.24) and Chinese populations (TT versus CC, OR=1.23, 95% CI 1.06-1.57). No associations were detected between GNB3-C825T and the risk of EH overall in Asian and Japanese people. Conclusions: Meta-analysis results suggest that the GNB3-C825T polymorphism is associated with risk of EH in the overall population, the Caucasians and the Chinese. The eff ect of the variants on the expression levels and the possible functional role of the variants in EH should be addressed in further studies.

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Section: Discussionsupporting

confidence: 82%

Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects

Zheng

Cui

et al. 2013

Biol. Res.

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“…The 825T allele is associated with alternative splicing of the gene and formation of a truncated but functionally active β 3 subunit and with enhanced G protein activation [18] . This polymorphism has been associated with multigenic disorders [19] , including hypertension [1] , and it seems to be a candidate for explaining human variability in exercise phenotypes. The GNB3 C825T polymorphism plays a minor role in heart rate and body fatness regulation in blacks, as well as in responsiveness of resting …”

Section: Introduction ▼mentioning

confidence: 99%

GNB3C825T Polymorphism and Elite Athletic Status: A Replication Study with Two Ethnic Groups

et al. 2010

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“…Searches for potential studies were carried out using keywords described in detail elsewhere [2] as well as personal contact with experts in the field. The following databases (from inception through 01 April, 2011) were screened: Pubmed, Web of Science, EMBASE, Biological Abstracts, LILACS and Google Scholar.…”

Section: Eligibility Criteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Polymorphisms in the GNB3 (chromosome 12p) have been associated with essential hypertension (EH) and obesity [2,3], but there is evidence for statistical heterogeneity (i.e. variation in effect estimates beyond chance) [2]. Thus, a major question so far has been whether these polymorphisms display a genuine effect when considered individually, or whether they might modulate the risk of hypertension/obesity when only certain variants are co-inherited (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

et al. 2014

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The objective of the present study was to review previous investigations on the association of haplotypes in the G-protein b3 subunit (GNB3) gene with representative cardiovascular risk factors/phenotypes: hypertension, overweight, and variation in the systolic and diastolic blood pressures (SBP and DBP, respectively) and as well as body mass index (BMI). A comprehensive literature search was undertaken in Pubmed, Web of Science, EMBASE, Biological Abstracts, LILACS and Google Scholar to identify potentially relevant articles published up to April 2011. Six genetic association studies encompassing 16,068 participants were identified. Individual participant data were obtained for all studies. The three most investigated GNB3 polymorphisms (G-350A, C825T and C1429T) were considered. Expectation-maximization and generalized linear models were employed to estimate haplotypic effects from data with uncertain phase while adjusting for covariates. Study-specific results were combined through a random-effects multivariate meta-analysis. After carefully adjustments for relevant confounding factors, our analysis failed to support a role for GNB3 haplotypes in any of the investigated phenotypes. Sensitivity analyses excluding studies violating Hardy-Weinberg expectations, considering gender-specific effects or more extreme phenotypes (e.g. obesity only) as well as a fixedeffects ''pooled'' analysis also did not disclose a significant influence of GNB3 haplotypes on cardiovascular phenotypes. We conclude that the previous cumulative evidence does not support the proposal that haplotypes formed by common GNB3 polymorphisms might contribute either to Electronic supplementary material The online version of this article

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The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14 094 cases and 17 760 controls

Cited by 65 publications

References 53 publications

Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects

Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects

GNB3C825T Polymorphism and Elite Athletic Status: A Replication Study with Two Ethnic Groups

Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

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The GNB3 C825T polymorphism and essential hypertension: a meta-analysis of 34 studies including 14 094 cases and 17 760 controls

Cited by 65 publications

References 53 publications

Association between polymorphism of the G-protein &#946;3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects

Association between polymorphism of the G-protein &#946;3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects

GNB3C825T Polymorphism and Elite Athletic Status: A Replication Study with Two Ethnic Groups

Multivariate meta-analysis of the association of G-protein beta 3 gene (GNB3) haplotypes with cardiovascular phenotypes

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Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects

Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects