The GlyphoMix protocol: Multiorgan changes in rats
caused by prenatal exposure to glyphosate or its mixture
with 2,4-D and dicamba

Mesnage, Robin; Nepka, Charitini; Ferguson, Scarlett; Kouretas, Demetrios; Stivaktakis, Polychronis; Calina, Daniela; Tsatsakis, Aristidis; Antoniou, Michael; Docea, Anca Oana

doi:10.18332/pht/161987

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…Globally, about four billion pounds of GYP is used every year [3]. The incidences of GYP toxicity are rising every year [4]; it causes toxicities in the gut, heart, kidney, and reproductive organs including the neuronal system [5]. In the neuronal tissue, GYP enhances neuronal excitation and loss of neuronal plasticity leads to neurodegenerations [6].…”

Section: Introductionmentioning

confidence: 99%

"Ameliorative Potential of Astaxanthin on Glyphosate- Induced Neurocognitive Functional Changes in Adult Zebrafish Via Acid Phosphatase and Annexin A2 Dysfunction"

Hasan Khan

2024

BJSTR

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Glyphosate (GYP) is a phosphonate type of herbicide and potentially causes neurodegenerations. Astaxanthin (AST) is a red pigment and is a group of carotenoids. It possesses potential antioxidants and neuroprotective actions. However, the ameliorative role of AST in GYP-induced neurocognitive dysfunction has not been studied yet. Hence, the present study is designed to investigate the ameliorative potential of AST in GYPinduced cognitive dysfunction via regulations of acid phosphatase (AP) and annexin A2 (AXA2) actions in the zebrafish model. The cognitive dysfunction was induced by exposure to GYP (0.5 mg/L for 30 minutes/ day) for 14 consecutive days. The AST (50, 75, and 100 mg/L for 30 minutes/day) and reference drug i.e., donepezil (DP; 1 µg/mL for 30 minutes/day) were exposed for 14 consecutive days before GYP exposure. On the 14th day, cognitive changes i.e., three horizontal compartment test, optokinetic motor response (OMR), startle response (SR), and T-maze tests were assessed. The changes of biomarkers i.e., acetylcholinesterase (AChE) activity, thio barbituric acid reactive substances (TBARS), reduced glutathione (GSH), AP, and AXA2 levels were estimated in brain tissue. The administration of AST ameliorates the GYP-induced neurocognitive dysfunctions via the antioxidant, regulation of AP and AXA2 actions. Hence, it can be used for neurocognitive disorders against the phosphonate type of herbicide (GYP) toxicity.

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Section: Introductionmentioning

confidence: 99%

"Ameliorative Potential of Astaxanthin on Glyphosate- Induced Neurocognitive Functional Changes in Adult Zebrafish Via Acid Phosphatase and Annexin A2 Dysfunction"

Hasan Khan

2024

BJSTR

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Ornamental plants as vectors of pesticide exposure and potential threat to biodiversity and human health

Chwoyka,

Linhard,

Durstberger

et al. 2024

Environ Sci Pollut Res

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The production of conventional ornamental plants is pesticide-intensive. We investigated whether pesticide active ingredients (AIs) are still present in ornamentals at the time of purchase and assessed their potential ecotoxicity to non-target organisms. We purchased 1000 pot plants and 237 cut flowers of different species from garden centers in Austria and Germany between 2011 and 2021 and analyzed them for up to 646 AIs. Ecotoxicological risks of AIs were assessed by calculating toxic loads for honeybees (Apis mellifera), earthworms (Eisenia fetida), birds (Passer domesticus), and mammals (Rattus norvegicus) based on the LD50 values of the detected AIs. Human health risks of AIs were assessed on the basis of the hazard statements of the Globally Harmonized System. Over the years, a total of 202 AIs were detected in pot plants and 128 AIs in cut flowers. Pesticide residues were found in 94% of pot plants and 97% of cut flowers, with cut flowers containing about twice as many AIs (11.0 ± 6.2 AIs) as pot plants (5.8 ± 4.0 AIs). Fungicides and insecticides were found most frequently. The ecotoxicity assessment showed that 47% of the AIs in pot plants and 63% of the AIs in cut flowers were moderately toxic to the considered non-target organisms. AIs found were mainly toxic to honeybees; their toxicity to earthworms, birds, and mammals was about 105 times lower. Remarkably, 39% of the plants labeled as “bee-friendly” contained AIs that were toxic to bees. More than 40% of pot plants and 72% of cut flowers contained AIs classified as harmful to human health. These results suggest that ornamental plants are vectors for potential pesticide exposure of consumers and non-target organisms in home gardens.

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The GlyphoMix protocol: Multiorgan changes in rats caused by prenatal exposure to glyphosate or its mixture with 2,4-D and dicamba

Cited by 2 publications

References 27 publications

"Ameliorative Potential of Astaxanthin on Glyphosate- Induced Neurocognitive Functional Changes in Adult Zebrafish Via Acid Phosphatase and Annexin A2 Dysfunction"

"Ameliorative Potential of Astaxanthin on Glyphosate- Induced Neurocognitive Functional Changes in Adult Zebrafish Via Acid Phosphatase and Annexin A2 Dysfunction"

Ornamental plants as vectors of pesticide exposure and potential threat to biodiversity and human health

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