The glycosaminoglycan-binding domain of PRELP acts as a cell type–specific NF-κB inhibitor that impairs osteoclastogenesis

Abstract

The PRELP heparin sulfate–binding protein translocates to the nucleus, where it impairs NF-κB transcriptional activity, which in turn regulates bone homeostasis.

Rsk2 controls synovial fibroblast hyperplasia and the course of arthritis

“…Adam8, which is a metalloproteinase induced by TNF acting as a sheddase for the TNF receptor I thereby limiting TNF activity,41 has the ability to limit leucocyte recruitment and inflammation 42 . Prelp , an extracellular matrix protein found in the synovial fluid of patients with RA, limits inflammation and complement activation-mediated cartilage attack and represses osteoclast differentiation 43 44 . Prg4 encodes for Lubricin, a protein essential for the maintenance of articular cartilage and a negative regulator of synovial hyperplasia, thereby protecting against arthritis-induced joint destruction 45–47 .…”

Stromal galectin-1 expression is associated with long-term survival in resectable pancreatic ductal adenocarcinoma

“…On a different note, prolargin (proline/arginine-rich end leucine-rich repeat protein) is a glycosaminoglycan and collagenbinding anchor protein that is abundantly expressed in cartilage, basement membranes and developing bone. 45 Previous studies have suggested that prolargin acts as a cell-type specific inhibitor of the NFκB pathway that impairs osteoclastogenesis. 45 In addition, increased NFκB activity has been shown to promote angiogenesis, invasion, metastasis, as well as chemoresistance in pancreatic cancer.…”

“…45 Previous studies have suggested that prolargin acts as a cell-type specific inhibitor of the NFκB pathway that impairs osteoclastogenesis. 45 In addition, increased NFκB activity has been shown to promote angiogenesis, invasion, metastasis, as well as chemoresistance in pancreatic cancer. 46 Thus, in VLTS, increased prolargin could potentially inhibit or diminish the NFκB signaling and thereby blocking tumorigenesis, invasion, angiogenesis and metastasis.…”

Glutamic acid ameliorates estrogen deficiency–induced menopausal-like symptoms in ovariectomized mice

“…G1251, minimum 99% pure; Sigma Chemical Co, St Louis, MO, USA) was dissolved in distilled water and prepared at a dose of 10 mg/kg, based on previous reports [19,20]. Estrogen (no.…”