The Glycopeptide Antibiotics

Greule, Anja; Cryle, Max J.

doi:10.1016/b978-0-12-409547-2.14691-8

Cited by 3 publications

(4 citation statements)

References 236 publications

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“…Based on intramolecular crosslinking patterns and post-synthesis modications, the GPAs are classied into ve types (types I-V). 207,208 Vancomycin, teicoplanin, and three semisynthetic GPAs, telavancin, dalbavancin and oritavancin, are representative GPAs currently used in clinic for the treatment of Gram-positive bacterial infections. In addition to the glycosylated heptapeptide core, teicoplanin, telavancin, dalbavancin and oritavancin contain a lipophilic group that provides additional antimicrobial activity.…”

Section: Lipoglycopeptidesmentioning

confidence: 99%

“…Researchers interested in lipoglycopeptides are suggested to read the reviews written by Nicolaou, 209 Hubbard, 227 Zhao 228 and Cryle. 207 2.4 Nucleoside-lipopeptides 2.4.1 Liposidomycin, caprazamycins and A-90289. This is a group of structurally-related liponucleoside antibiotics isolated from Streptomyces.…”

Section: Lipoglycopeptidesmentioning

confidence: 99%

“…Researchers interested in lipoglycopeptides are suggested to read the reviews written by Nicolaou, 209 Hubbard, 227 Zhao 228 and Cryle. 207…”

Section: Identification and Biosynthesis Of Lipopeptides From Strepto...mentioning

confidence: 99%

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Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces

et al. 2023

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Section: Lipoglycopeptidesmentioning

confidence: 99%

Section: Lipoglycopeptidesmentioning

confidence: 99%

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Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces

et al. 2023

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“…Neither a synthesis scheme has been proposed nor evaluated as an ANG inhibitor for its anti‐ribonucleolytic activity. Further, tyrosine amino acid has flexible side chain which was replaced with para‐hydroxyl‐phenyl glycine (Normtyr‐1) to enhance rigidity in PNA since the aromatic ring is attached to the alpha carbon of the peptide bond, which significantly restricts the sidechain flexibility, hence increases the rigidity in ligand rather than serine to get stable binding to catalytic site and better binding affinity (Greule & Cryle, 2020).…”

Section: Introductionmentioning

confidence: 99%

An in silico comparative study of curcumin and 2‐deoxyuridine nucleoside derivatives: Reveals the role of angiogenin in ER stress‐induced apoptosis signaling

Ahmad

Lakshmi

2023

Chem Biol Drug Des

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Angiogenin (ANG) protein plays a crucial role in angiogenesis, neovascularization, and cancer metastasis in NSCLC (non‐small cell lung cancer) via non‐coding tiRNA. It protects the cell under ER (endoplasmic reticulum) stress‐induced apoptosis through the translational reprogramming process. Although B82 (Curcumin derivatives) induces ER stress‐induced apoptosis, its mechanism of action was not studied. Therefore, it was hypothesized that the ribonucleolytic activity of ANG may be regulated by B82, resulting in modulated ER stress signaling for apoptosis. Hence, we designed and proposed a synthesis scheme for RNA‐based anti‐angiogenic derivatives of 2‐deoxyuridine nucleoside forming peptide bond with amino acids like serine (Ser‐3) and para‐hydroxy‐phenyl glycine (Normtyr‐1) and compared B82 with them to know the binding affinity with ANG, anti‐angiogenic potential, and its probable mechanism of anti‐RNase activity through MD simulation study. Therefore, using Gromos96 43a1 and 43a2 force fields, MD simulation was performed to investigate binding affinity, ligand‐induced molecular surface area change, conformational change, and dynamics of catalytic site residues to predict ligand binding to ANG in this study. The obtained binding free energy (∆Gbind) result showed the total average ∆Gbind as −113.480 ± 1.682 (Normtyr‐1) > −53.038 ± 33.069 (B82) > −27.909 ± 16.438 (Ser‐3) kJ/mole specify role of B82 in regulating ER stress signaling induced apoptosis through ANG ribonucleolytic activity inhibition, suitability of 43a2 force fields and methodology in ligand screening. It shows the crucial role of Leu115 and His13 residue involvement in total ∆Gbind contribution. Hence, based on the MD result, novel conformation of catalytic residues, and ∆Gbind, a promising combination candidate could be proposed for metastatic NSCLC therapy.

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Is there a role for intestinal sporobiota in the antimicrobial resistance crisis?

Romero-Rodríguez,

Ruíz-Villafán,

Sánchez

et al. 2024

Microbiological Research

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The Glycopeptide Antibiotics

Cited by 3 publications

References 236 publications

Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces

Structural diversity, biosynthesis, and biological functions of lipopeptides fromStreptomyces

An in silico comparative study of curcumin and 2‐deoxyuridine nucleoside derivatives: Reveals the role of angiogenin in ER stress‐induced apoptosis signaling

Is there a role for intestinal sporobiota in the antimicrobial resistance crisis?

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