The glyconanoparticle as carrier for drug delivery

Zhang, Xueqin; Huang, Gangliang; Huang, Hualiang

doi:10.1080/10717544.2018.1519001

Cited by 34 publications

(26 citation statements)

References 46 publications

(37 reference statements)

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“…Lectins are overexpressed in some tumor cells [30,31]. Thus, decorating nanoparticles of different types with carbohydrates is an efficient approach to increase the local concentration of anticancer drugs near tumor cells, facilitating specific cellular uptake through the specific binding between the carbohydrate ligand and the overexpressed specific lectin [32,33]. Among this family of proteins, mannose-binding lectins (MBLs) are overexpressed by many human cancer cells and may be used as therapeutic targets [30].…”

Section: Introductionmentioning

confidence: 99%

Design of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Media

Cutrone

Casas-Solvas

et al. 2019

Nanomaterials

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Nanosized metal-organic frameworks (nanoMOFs) MIL-100(Fe) are highly porous and biodegradable materials that have emerged as promising drug nanocarriers. A challenging issue concerns their surface functionalization in order to evade the immune system and to provide molecular recognition ability, so that they can be used for specific targeting. A convenient method for their coating with tetraethylene glycol, polyethylene glycol, and mannose residues is reported herein. The method consists of the organic solvent-free self-assembly on the nanoMOFs of building blocks based on β-cyclodextrin facially derivatized with the referred functional moieties, and multiple phosphate groups to anchor to the nanoparticles’ surface. The coating of nanoMOFs with cyclodextrin phosphate without further functional groups led to a significant decrease of macrophage uptake, slightly improved by polyethylene glycol or mannose-containing cyclodextrin phosphate coating. More notably, nanoMOFs modified with tetraethylene glycol-containing cyclodextrin phosphate displayed the most efficient “stealth” effect. Mannose-coated nanoMOFs displayed a remarkably enhanced binding affinity towards a specific mannose receptor, such as Concanavalin A, due to the multivalent display of the monosaccharide, as well as reduced macrophage internalization. Coating with tetraethylente glycol of nanoMOFs after loading with doxorubicin is also described. Therefore, phosphorylated cyclodextrins offer a versatile platform to coat nanoMOFs in an organic solvent-free, one step manner, providing them with new biorecognition and/or “stealth” properties.

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Section: Introductionmentioning

confidence: 99%

Design of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Media

Cutrone

Casas-Solvas

et al. 2019

Nanomaterials

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“…In this section, the application of carbohydrates in the modification of nanomaterials is highlighted. Considering their ubiquitous distribution in tissues and important functions at the cellular for the design, preparation, and application of glyconanomaterials have been summarized in many recent reviews (Gorityala et al, 2010;Marradi et al, 2013;Hao et al, 2016;Zhang et al, 2018;Khan et al, 2019). Generally, carbohydrates have three typical advantages in the development of nanomedicine.…”

Section: Glyconanomaterialsmentioning

confidence: 99%

“…Considering their ubiquitous distribution in tissues and important functions at the cellular level, carbohydrates have been widely used in the functionalization of nanomaterials and have shown unique advantages in the development of nanomedicines. Strategies for the design, preparation, and application of glyconanomaterials have been summarized in many recent reviews ( Gorityala et al, 2010 ; Marradi et al, 2013 ; Hao et al, 2016 ; Zhang et al, 2018 ; Khan et al, 2019 ). Generally, carbohydrates have three typical advantages in the development of nanomedicine.…”

Section: Introductionmentioning

confidence: 99%

Exploring Carbohydrates for Therapeutics: A Review on Future Directions

Wang

Zhang

et al. 2021

Front. Pharmacol.

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Carbohydrates are important components of foods and essential biomolecules performing various biological functions in living systems. A variety of biological activities besides providing fuel have been explored and reported for carbohydrates. Some carbohydrates have been approved for the treatment of various diseases; however, carbohydrate-containing drugs represent only a small portion of all of the drugs on the market. This review summarizes several potential development directions of carbohydrate-containing therapeutics, with the hope of promoting the application of carbohydrates in drug development.

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“…In this review, we focus only on protein expression, since that information is the only relevant one for the development of targeted drug delivery systems. More information about carbohydrate-based nanocarriers for targeted drug delivery systems can be found elsewhere [ 8 , 9 , 10 ]. Since lectins are able to recognize and transport carbohydrates and their derivatives, lectin targeting can be relevant in the research and development of new medicines [ 7 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Human Lectins, Their Carbohydrate Affinities and Where to Find Them

2021

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Lectins are a class of proteins responsible for several biological roles such as cell-cell interactions, signaling pathways, and several innate immune responses against pathogens. Since lectins are able to bind to carbohydrates, they can be a viable target for targeted drug delivery systems. In fact, several lectins were approved by Food and Drug Administration for that purpose. Information about specific carbohydrate recognition by lectin receptors was gathered herein, plus the specific organs where those lectins can be found within the human body.

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The glyconanoparticle as carrier for drug delivery

Cited by 34 publications

References 46 publications

Design of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Media

Design of Engineered Cyclodextrin Derivatives for Spontaneous Coating of Highly Porous Metal-Organic Framework Nanoparticles in Aqueous Media

Exploring Carbohydrates for Therapeutics: A Review on Future Directions

Human Lectins, Their Carbohydrate Affinities and Where to Find Them

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