2018
DOI: 10.1016/j.bpj.2017.11.1268
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The Glycolytic Enzyme Phosphofructokinase-1 Assembles into Filaments

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Cited by 15 publications
(30 citation statements)
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“…Moreover, the platelet isoform of PFK1 (PFKP) is recruited to the membrane by activated EGFRs and is overexpressed in PDAC (Fig. 1a) [22], whilst the liver isoform of PFK1 (PFKL) has been found to oligomerize to form filaments which were enriched at the plasma membrane [49].…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, the platelet isoform of PFK1 (PFKP) is recruited to the membrane by activated EGFRs and is overexpressed in PDAC (Fig. 1a) [22], whilst the liver isoform of PFK1 (PFKL) has been found to oligomerize to form filaments which were enriched at the plasma membrane [49].…”
Section: Discussionmentioning
confidence: 99%
“…Chemotaxis of myeloid cells like other types of cells is also known to require energy in the form of ATP that is produced on demand during migration. ATP is rapidly consumed within the cytosol to fuel the remodeling of the actin cytoskeleton necessary for cell migration …”
Section: Metabolic Regulation Of Myeloid Cell Migrationmentioning
confidence: 99%
“…Using both transmission electron microscopy and 90° light scattering, Webb et al (2017) demonstrated that a recombinant liver-specific isoform of PFK1 (liver PFK1; PFKL) forms filaments in vitro. However, filament assembly was not observed in platelet PFK1 (PFKP)- or muscle PFK1–specific isoforms.…”
mentioning
confidence: 99%
“…In addition to identifying PFKL polymerization, Webb et al (2017) examined the filament structure with negative-stain EM and iterative helical real-space reconstruction. They found that PFKL filaments are distinct from other filamentous enzymes.…”
mentioning
confidence: 99%
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