The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients

Comino, Isabel; Moreno, María de Lourdes; Real, Ana; Rodríguez‐Herrera, Alfonso; Barro, Francisco; Sousa, Carolina

doi:10.3390/nu5104250

Cited by 85 publications

(59 citation statements)

References 78 publications

(113 reference statements)

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“…Our study showed that both cultivars do not display in vitro activities related to CD pathogenesis . Other in vitro studies have shown that the immunogenicity of oats varies depending on the cultivar used . Recently, long‐term cohort studies as well as short‐term intervention studies have revealed that oats consumption by CD patients is safe, provided that the products are uncontaminated with wheat, barley, or rye .…”

Section: New Dietary Opportunity For Ncgs Patientsmentioning

confidence: 99%

Non‐Celiac Gluten Sensitivity: How Its Gut Immune Activation and Potential Dietary Management Differ from Celiac Disease

Aufiero

Fasano

Mazzarella

2018

Molecular Nutrition Food Res

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Non-celiac gluten sensitivity (NCGS) is a clinical entity triggered by the ingestion of gluten-containing grains leading to intestinal and/or extraintestinal symptoms that resolve once the gluten-containing foodstuff is eliminated from the diet, and it is diagnosed when celiac disease (CD) and wheat allergy (WA) have been ruled out. The limited knowledge about the pathophysiology of NCGS and the lack of validated biomarkers are still major limitations for clinical studies, making it difficult to differentiate NCGS from other gluten-related disorders (GRD). In the absence of clear-cut diagnostic criteria, NCGS is still mainly a diagnosis of exclusion. Several studies suggest that NCGS is an immune-mediated disease that likely activates an innate immune response. Moreover, it has recently been hypothesized that in addition to gluten, other components of wheat may be responsible for the symptoms observed in individuals without CD. This review aims at discussing available evidence related to the histological and immunological features in the gut mucosa of patients with NCGS and at outlining new dietary opportunities for these patients.

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Section: New Dietary Opportunity For Ncgs Patientsmentioning

confidence: 99%

Non‐Celiac Gluten Sensitivity: How Its Gut Immune Activation and Potential Dietary Management Differ from Celiac Disease

Aufiero

Fasano

Mazzarella

2018

Molecular Nutrition Food Res

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“…In fact, it was suggested that PREP may be released from the cells (Ahmed et al, ), even though it lacks a secretion signal and it does not contain a transmembrane region, or a lipid anchor sequence (Venäläinen et al, ). PREP has been implicated in several biological processes, including cognitive disorders (Rossner et al, ; Hannula et al, ), celiac disease (Siegel et al, ; Comino et al, ), cell death (Bär et al, ; Matsuda et al, ), learning and memory (Irazusta et al, ; D'Agostino et al, ), cell proliferation and differentiation (Matsubara et al, ; Suzuki et al, ), and glucose metabolism (Kim et al, ). However, its physiological role remains to be elucidated.…”

mentioning

confidence: 99%

Prolyl Endopeptidase (PREP) is Associated With Male Reproductive Functions and Gamete Physiology in Mice

Dotolo

Kim

Pariante³

et al. 2015

Journal Cellular Physiology

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Prolyl endopeptidase (PREP) is a serine protease which has been implicated in many biological processes, such as the maturation and degradation of peptide hormones and neuropeptides, learning and memory, cell proliferation and differentiation, and glucose metabolism. A small number of reports have also suggested PREP participation in both male and female reproduction-associated processes. In the present work, we examined PREP distribution in male germ cells and studied the effects of its knockdown (Prep(gt/gt)) on testis and sperm in adult mice. The protein is expressed and localized in elongating spermatids and luminal spermatozoa of wild type (wt) mice, as well as Sertoli, Leydig, and peritubular cells. PREP is also expressed in the head and midpiece of epididymal spermatozoa, whereas the remaining tail region shows a weaker signal. Furthermore, testis weight, histology of seminiferous tubules, and epididymal sperm parameters were assessed in wt and Prep(gt/gt) mice: wild type testes have larger average tubule and lumen diameter; in addition, lumenal composition of seminiferous tubules is dissimilar between wt and Prep(gt/gt), as the percentage of spermiated tubules is much higher in wt. Finally, total sperm count, sperm motility, and normal morphology are also higher in wt than in Prep(gt/gt). These results show for the first time that the expression of PREP could be necessary for a correct reproductive function, and suggest that the enzyme may play a role in mouse spermatogenesis and sperm physiology.

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“…Despite its common cytosolic localization and the lacks of a secretion signal or a lipid anchor sequence (Venäläinen et al, 2004), it is believed that PREP may be released from the cells and act outside by inactivating extracellular neuropeptides (Ahmed et al, 2005). PREP has been implicated in several biological processes, including cell proliferation and differentiation (Matsubara et al, 1998; Suzuki et al, 2014), cell death (Bär et al, 2006; Matsuda et al, 2013), glucose metabolism (Kim et al, 2014), celiac disease (Siegel et al, 2006; Comino et al, 2013), learning and memory (Irazusta et al, 2002; D’Agostino et al, 2013) and cognitive disorders (Rossner et al, 2005; Hannula et al, 2013). Further reports about the intracellular activity of PREP suggested an additional physiological role for this enzyme (Schulz et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Prolyl Endopeptidase (PREP) is Involved in the Reproductive Functions and Cytoskeletal Organization in Rat Spermatogenesis and in Mammalian Sperm

Venditti¹,

Minucci²

2018

Preprint

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In this paper we show the co-localization of the enzyme PREP with tubulin during the first wave of rat spermatogenesis and in mature gametes of rat and human. 2 AbstractProlyl endopeptidase (PREP) is an enzyme which cleaves several peptide hormones and 1 neuropeptides at the carboxyl side of proline residues, involved in many biological processes, 2 including cell proliferation and differentiation, glucose metabolism, learning, memory and cognitive 3 disorders. Moreover, PREP was identified as binding partner of tubulin, suggesting that this 4 endopeptidase may be involved in microtubule-associate processes, independent of its peptidase 5 activity. Several reports have also suggested PREP participation in both male and female 6 reproduction-associated processes. In this work, we assessed the possible association of PREP with 7 the morphogenesis of rat testis, profiling its localization versus tubulin, during the first wave of 8 spermatogenesis and in the adult gonad (from 7 to 60 dpp). Here we show that, in mitotic phases, 9 PREP shares its localization with tubulin in Sertoli cells, gonocytes and spermatogonia. Later, 10 during meiosis, both proteins are found in spermatocytes, and in the cytoplasm of Sertoli cells 11 protrusions, which surround the germ cells, while, during spermiogenesis, they both localize in the 12 cytoplasm of round and elongating spermatids. Finally, they are expressed in the flagellum of 13 mature gametes, as corroborated by additional immunolocalization analysis on both rat and human 14 sperm. Our data strongly support the hypothesis of a role of PREP in supporting a correct 15 reproductive function and in cytoskeletal organization during Mammalian testis morphogenesis and 16 gamete progression, while also hinting at its possible investigation as a morphological marker of 17 germ cell and sperm physiology. 18

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The Gluten-Free Diet: Testing Alternative Cereals Tolerated by Celiac Patients

Cited by 85 publications

References 78 publications

Non‐Celiac Gluten Sensitivity: How Its Gut Immune Activation and Potential Dietary Management Differ from Celiac Disease

Non‐Celiac Gluten Sensitivity: How Its Gut Immune Activation and Potential Dietary Management Differ from Celiac Disease

Prolyl Endopeptidase (PREP) is Associated With Male Reproductive Functions and Gamete Physiology in Mice

Prolyl Endopeptidase (PREP) is Involved in the Reproductive Functions and Cytoskeletal Organization in Rat Spermatogenesis and in Mammalian Sperm

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