The glutathione biosynthesis is involved in metamorphosis, antioxidant function, and insecticide resistance in Tribolium castaneum
KumChol Kim,
Han Gao,
Chengjun Li
et al.
Abstract:BACKGROUNDReduced glutathione (GSH) synthesis is vital for redox homeostasis, cell‐cycle regulation and apoptosis, and immune function. The glutamate–cysteine ligase catalytic subunit (Gclc) is the first and rate‐limiting enzyme in GSH synthesis, suggesting the potential use of Gclc as a pesticide target. However, the functional characterization of Gclc, especially its contribution in metamorphosis, antioxidant status and insecticide resistance, is unclear in Tribolium castaneum.RESULTSIn this study, we identi… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.