The glutamine 27 β-adrenoceptor polymorphism is associated with elevated IgE levels in asthmatic families

Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice

“…Both polymorphism in the 5Ј flanking region of the human CD14 on chromosome 5q31.1 and in ␤2 adrenergic receptor were shown to be associated with total serum IgE. 20,21 Locus SM1 in the region 5q31-q33 determines the intensity of infection by Schistosoma mansoni 22 and may also influence blood level of Plasmodium falciparum. 23 IgE plays an important role in the response to helminth infections 1 and therefore it cannot be excluded that responses controlled by Lmr13 and SM1 are influenced by the same (homologous) gene.…”

The pharmacogenetics of asthma: a candidate gene approach

“…31 These in vitro observations are consistent with many clinical studies examining potential roles of ␤ 2 AR polymorphisms in asthma. Some of these clinical studies have examined potential disease modifying effects, such as severity, 32 phenotype, 33,34 and physiologic parameters. 35 A few studies have examined pharmacogenetic relationships between these polymorphisms and the response to ␤-agonists.…”

Linkage analysis of the 5q31–33 candidate region for asthma in 240 UK families

“…Data for four other markers previously typed were included in the linkage analysis, the (CA) n repeqat markers IL4 and IL9 16 and the single nucleotide polymorphisms R16G and Q27E of the ADRB2 gene. 15 Groups of markers were pooled together for multiplexing. 0.5 l internal lane size standards (GeneScan 500-TAMRA, PE Biosystems), 1.66 l of formamide and 0.33 l of loading dye were mixed with 1/10 volume of the pooled PCR products.…”

“…[9][10][11][12][13][14] In order to investigate this further, we have genotyped 10 markers on chromosome 5 in a large UK Caucasian sample of 240 families comprising 1216 individuals extensively phenotyped for atopy and asthma. In addition we have used data from four additional markers previously typed within the population 15,16 and incorporated phenotype scores in the analysis in attempt to confirm previous findings of linkage to 5q31-33 and define the area of interest.…”