The Glucose Challenge Test for Screening of Gestational Diabetes

Shrestha, Abha; Chawla, C D

doi:10.3126/kumj.v9i2.6282

Cited by 14 publications

(21 citation statements)

References 8 publications

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“…In the present study, a 50-g oral GCT was conducted as part of a standard screening for GDM, as GCT is feasible, easy, user-friendly, cost-effective and convenient for screening purposes (22).…”

Section: B a B Amentioning

confidence: 99%

Evaluation of oral glucose tolerance test, β-cell function and adverse obstetric outcomes

et al. 2013

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Abstract. This study was conducted in order to investigate the prevalence of impaired glucose tolerance (IGT) and gestational diabetes mellitus (GDM), their effect on pregnancy and their association with adverse obstetric outcomes. A cross-sectional study was performed on 345 pregnant women, who were screened between the 24th and 28th gestational week with a 75-g oral glucose tolerance test following abnormal results at 1 h after a 50-g oral glucose challenge test. The obstetric outcomes were recorded along with plasma glucose and insulin levels, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function index (HOMA-βCFI) and 50 subjects were excluded due to incomplete data recovery. Of the 295 pregnant women, 18.6% (55/295) were diagnosed with GDM and 32% (95/295) with IGT. The GDM group exhibited significantly higher fasting and 1-h blood glucose concentrations compared to the normal glucose tolerance (NGT) and IGT groups (P<0.01). The 2-and 3-h insulin values of the NGT group were significantly lower compared to those of the GDM group (P<0.05, P<0.01). In the IGT group, the 2-h insulin values were higher compared to the NGT group and the 3-h values were significantly higher (P<0.01), similar to the GDM group. There was a tendency for progressively decreased β-cell function and increased HOMA-IR from the NGT to the IGT to the GDM group. The adverse outcomes of pregnancy-induced hypertension, fetal distress, neonatal hyperbilirubinemia, preterm delivery, macrosomia and cesarean delivery indicated an association with HOMA-βCFI and HOMA-IR. In conclusion, these findings suggest a clinical significance of β-cell dysfunction in women with gestational IGT.

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Section: B a B Amentioning

confidence: 99%

Evaluation of oral glucose tolerance test, β-cell function and adverse obstetric outcomes

et al. 2013

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“…Prevalence of GDM in a study done in Tribhuvan University Teaching Hospital (TUTH) Kathmandu was 0.6%, in Dhulikhel Hospital, it was 0.75% and in Kathmandu Medical College, it was 1.58%. [24][25][26] In all these studies screening test was done with 50 gm GCT and confirmation done with 75 gm OGTT. These studies were done long time back as compared to our study.…”

Section: Discussionmentioning

confidence: 99%

“…11 GDM is in increasing trend world wide, 7,12,14,15 and same can be seen in Nepal. [24][25][26][27][28][29] Maternal age is strongly associated with GDM. In many studies it was reported that prevalence of GDM is increased with maternal age.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Gestational Diabetes, Risk Factors and its Outcome in a Tertiary Hospital

Shreshta¹,

Shrestha²

2018

Nep. Med. Coll. J.

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Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. GDM increases the risk of adverse maternal and perinatal outcome and increases risk of diabetes in mother and child in the future. Prevalence of GDM is increasing all over the world. This is hospital based cross sectional study done in Department of Obstetrics and Gynecology, Nepal Medical College and Teaching Hospital to find out the prevalence of GDM and to trace maternal and fetal risk factors and adverse outcome. In this study, 600 pregnant women were enrolled during 2016-17. Among them 27 (4.5%) were found to have GDM. Among GDM, four (14.4%) were ≥ 35 years old and six (22.2%) had BMI of ≥ 25 kg/m2. Caesarean section was more common mode of delivery in women with GDM than without (51.9% vs 22.2%). Increased prevalence shown in this study necessitates universal screening of GDM.

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“…This opinion has been shared by other investigators: Shrestha et al, concluded that the 50 g OGCT is a reliable test to detect GDM. This test is easy to administer and cost-effective for screening purpose [17]. A systemic review by van Leeuwen et al, in 2010 concluded that the 50-g OGCT is acceptable to screen for GDM [18].…”

Section: Discussionmentioning

confidence: 99%

50 Grams Oral Glucose Challenge Test: Is It an Effective Screening Test for Gestational Diabetes Mellitus?

Abu-Heija

Al-Bash

Ishrat

et al. 2015

J Obstet Gynecol India

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Aim To find out whether 50 g oral glucose challenge test (OGCT) is an effective screening test for all pregnant women between 24 and 28 weeks gestation. Method A 50 g OGCT test was administered to 307 unselected women at 24-28 weeks of gestation. When venous plasma glucose (VPG) concentration after 1 h was [7.8 mmol/l, OGCT was positive. Women with a positive OGCT underwent 2 h 75 grams oral glucose tolerance test (OGTT) as a confirmatory diagnosis of GDM. When fasting and 2 h post 75 g OGTT values were [5.5 mmol/I and [8 mmol/l, respectively, women were considered diabetic. Results We screened 307 women for GDM by OGCT. Total number of women with positive OGCT was 83 (27.03 %). In the low-risk group, total number of women with GDM was 9/168 (5.35 %) while the total number of women with GDM in the high-risk group was 14/139 (10.07 %). There was no significant difference with respect to the total number of women with GDM in the groups. Conclusions A 50 g OGCT seems to be an effective screening test for both groups. More cases of GDM can be discovered when universal rather than risk-related screening is applied.

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The Glucose Challenge Test for Screening of Gestational Diabetes

Cited by 14 publications

References 8 publications

Evaluation of oral glucose tolerance test, β-cell function and adverse obstetric outcomes

Evaluation of oral glucose tolerance test, β-cell function and adverse obstetric outcomes

Prevalence of Gestational Diabetes, Risk Factors and its Outcome in a Tertiary Hospital

50 Grams Oral Glucose Challenge Test: Is It an Effective Screening Test for Gestational Diabetes Mellitus?

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